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PMID: 17074298 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Regulation of G protein-coupled receptor export trafficking.

Biochimica et biophysica acta ·Vol. 1768 ·No. 4 ·2007-04-00 ·Pages 853-70

Dong C, Filipeanu CM, Duvernay MT, Wu G

Abstract

G protein-coupled receptors (GPCRs) constitute a superfamily of cell-surface receptors which share a common topology of seven transmembrane domains and modulate a variety of cell functions through coupling to heterotrimeric G proteins by responding to a vast array of stimuli. The magnitude of cellular response elicited by a given signal is dictated by the level of GPCR expression at the plasma membrane, which is the balance of elaborately regulated endocytic and exocytic trafficking. This review will cover recent advances in understanding the molecular mechanism underlying anterograde transport of the newly synthesized GPCRs from the endoplasmic reticulum (ER) through the Golgi to the plasma membrane. We will focus on recently identified motifs involved in GPCR exit from the ER and the Golgi, GPCR folding in the ER and the rescue of misfolded receptors from within, GPCR-interacting proteins that modulate receptor cell-surface targeting, pathways that mediate GPCR traffic, and the functional role of export in controlling GPCR signaling.

MeSH Terms
Amino Acid Motifs/genetics Animals Endoplasmic Reticulum/metabolism Golgi Apparatus/metabolism Protein Folding Protein Transport Proteins/chemistry,metabolism Receptors, G-Protein-Coupled/chemistry,genetics,metabolism
Chemicals
Proteins Receptors, G-Protein-Coupled
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Dong Chunmin
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Filipeanu Catalin M
Duvernay Matthew T
Wu Guangyu
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbamem.2006.09.008
Published
2007-04-00
Epub
2006-00-23
Pages
853-70
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC1885203
Subset
IM
Grants
NCRR NIH HHS · P20 RR018766 · United States
NIGMS NIH HHS · R01 GM076167 · United States
NIGMS NIH HHS · GM76167 · United States
NCRR NIH HHS · RR18766 · United States
External Links
PubMed source DOI: 10.1016/j.bbamem.2006.09.008 PMC Full Text
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