Home LiteratureArticle Details
PMID: 16829980 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The biogenesis and regulation of telomerase holoenzymes.

Nature reviews. Molecular cell biology ·Vol. 7 ·No. 7 ·2006-07-00 ·Pages 484-94

Collins K

Abstract

Chromosome stability requires a dynamic balance of DNA loss and gain in each terminal tract of telomeric repeats. Repeat addition by a specialized reverse transcriptase, telomerase, has an important role in maintaining this equilibrium. Insights that have been gained into the cellular pathways for biogenesis and regulation of telomerase ribonucleoproteins raise new questions, particularly concerning the dynamic nature of this unique polymerase.

MeSH Terms
Chromosomal Instability Chromosomes, Fungal/genetics,metabolism DNA/metabolism DNA-Binding Proteins/chemistry,metabolism Holoenzymes/chemistry,genetics,metabolism Humans RNA/metabolism Ribonucleoproteins/genetics,metabolism Telomerase/chemistry,genetics,metabolism Telomere/metabolism
Chemicals
DNA-Binding Proteins Holoenzymes Ribonucleoproteins RNA DNA Telomerase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Collins Kathleen
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3204, USA. kcollins@berkeley.edu
References (159)
159 references, click to expand
  1. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase.
    J Biol Chem. 2001 May 11;276(19):15571-4 PMID: 11274138
  2. Requirements for the dGTP-dependent repeat addition processivity of recombinant Tetrahymena telomerase.
    J Biol Chem. 2001 Feb 16;276(7):4863-71 PMID: 11096070
  3. Human telomerase contains two cooperating telomerase RNA molecules.
    EMBO J. 2001 Jul 2;20(13):3526-34 PMID: 11432839
  4. The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo.
    RNA. 2001 Aug;7(8):1068-75 PMID: 11497426
  5. Functional multimerization of the human telomerase reverse transcriptase.
    Mol Cell Biol. 2001 Sep;21(18):6151-60 PMID: 11509658
  6. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita.
    Nature. 2001 Sep 27;413(6854):432-5 PMID: 11574891
  7. N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo.
    Mol Cell Biol. 2001 Nov;21(22):7775-86 PMID: 11604512
  8. Tetrahymena proteins p80 and p95 are not core telomerase components.
    Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12368-73 PMID: 11592988
  9. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.
    Cell. 2001 Nov 2;107(3):347-59 PMID: 11701125
  10. Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again.
    Differentiation. 2002 Jan;69(4-5):188-97 PMID: 11841477
  11. Template boundary definition in Tetrahymena telomerase.
    Genes Dev. 2002 Feb 15;16(4):415-20 PMID: 11850404
  12. Telomerase in the human organism.
    Oncogene. 2002 Jan 21;21(4):564-79 PMID: 11850781
  13. Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction.
    Mol Cell Biol. 2002 Apr;22(7):2366-74 PMID: 11884619
  14. Telomerase recognizes its template by using an adjacent RNA motif.
    Proc Natl Acad Sci U S A. 2002 May 14;99(10):6585-90 PMID: 11997465
  15. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes.
    Annu Rev Biochem. 2002;71:165-89 PMID: 12045094
  16. Nucleolar localization of hTERT protein is associated with telomerase function.
    Exp Cell Res. 2002 Jul 15;277(2):201-9 PMID: 12083802
  17. The nucleolar localization domain of the catalytic subunit of human telomerase.
    J Biol Chem. 2002 Jul 5;277(27):24764-70 PMID: 11956201
  18. Association between aplastic anaemia and mutations in telomerase RNA.
    Lancet. 2002 Jun 22;359(9324):2168-70 PMID: 12090986
  19. Intracellular trafficking of yeast telomerase components.
    EMBO Rep. 2002 Jul;3(7):652-9 PMID: 12101098
  20. Interactions between telomerase and primase physically link the telomere and chromosome replication machinery.
    Mol Cell Biol. 2002 Aug;22(16):5859-68 PMID: 12138196
  21. Connecting chromosomes, crisis, and cancer.
    Science. 2002 Jul 26;297(5581):565-9 PMID: 12142527
  22. Telomerase beyond telomeres.
    Nat Rev Cancer. 2002 Aug;2(8):627-33 PMID: 12154355
  23. Biogenesis of yeast telomerase depends on the importin mtr10.
    Mol Cell Biol. 2002 Sep;22(17):6046-55 PMID: 12167699
  24. C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity.
    Mol Cell Biol. 2002 Sep;22(17):6234-46 PMID: 12167716
  25. Est1p as a cell cycle-regulated activator of telomere-bound telomerase.
    Science. 2002 Aug 9;297(5583):1023-6 PMID: 12169735
  26. Subnuclear shuttling of human telomerase induced by transformation and DNA damage.
    Nat Cell Biol. 2002 Sep;4(9):731-6 PMID: 12198499
  27. The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein.
    Mol Biol Cell. 2002 Sep;13(9):3192-202 PMID: 12221125
  28. Telomerase extracurricular activities.
    Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12520-2 PMID: 12271146
  29. Telomerase: a target for cancer therapeutics.
    Cancer Cell. 2002 Oct;2(4):257-65 PMID: 12398889
  30. A bulged stem tethers Est1p to telomerase RNA in budding yeast.
    Genes Dev. 2002 Nov 1;16(21):2800-12 PMID: 12414733
  31. Telomerase: biochemical considerations for enzyme and substrate.
    Trends Biochem Sci. 2002 Nov;27(11):572-9 PMID: 12417133
  32. Studies on the minimal lengths required for DNA primers to be extended by the Tetrahymena telomerase: implications for primer positioning by the enzyme.
    Nucleic Acids Res. 2002 Dec 15;30(24):5570-8 PMID: 12490725
  33. Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.
    Cancer Res. 2003 Jan 1;63(1):18-21 PMID: 12517770
  34. The telomerase-associated protein p43 is involved in anchoring telomerase in the nucleus.
    J Cell Sci. 2003 May 1;116(Pt 9):1757-61 PMID: 12665556
  35. A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed.
    Curr Biol. 2003 Apr 1;13(7):568-74 PMID: 12676087
  36. Telomere maintenance in fission yeast requires an Est1 ortholog.
    Curr Biol. 2003 Apr 1;13(7):575-80 PMID: 12676088
  37. Functional conservation of the telomerase protein Est1p in humans.
    Curr Biol. 2003 Apr 15;13(8):698-704 PMID: 12699629
  38. The RNA subunit of telomerase is encoded by Marek's disease virus.
    J Virol. 2003 May;77(10):5985-96 PMID: 12719590
  39. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit.
    Biochemistry. 2003 May 20;42(19):5736-47 PMID: 12741831
  40. Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs.
    Mol Cell. 2003 May;11(5):1361-72 PMID: 12769858
  41. Developmentally programmed gene elimination in Euplotes crassus facilitates a switch in the telomerase catalytic subunit.
    Cell. 2003 May 30;113(5):565-76 PMID: 12787498
  42. Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA.
    J Biol Chem. 2005 Apr 29;280(17):17533-9 PMID: 15731105
  43. The many facets of H/ACA ribonucleoproteins.
    Chromosoma. 2005 May;114(1):1-14 PMID: 15770508
  44. Telomerase: what are the Est proteins doing?
    Curr Opin Cell Biol. 2003 Jun;15(3):275-80 PMID: 12787768
  45. Telomeres and telomerase in aging, regeneration and cancer.
    Mol Cells. 2003 Apr 30;15(2):164-75 PMID: 12803478
  46. Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.
    Mol Cell Biol. 2003 Jul;23(13):4598-610 PMID: 12808100
  47. Roles for RNA in telomerase nucleotide and repeat addition processivity.
    Mol Cell. 2003 Jun;11(6):1673-83 PMID: 12820978
  48. Telomere maintenance and disease.
    Lancet. 2003 Sep 20;362(9388):983-8 PMID: 14511933
  49. Telomerase RNA accumulates in Cajal bodies in human cancer cells.
    Mol Biol Cell. 2004 Jan;15(1):81-90 PMID: 14528011
  50. Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal.
    J Cell Biol. 2004 Mar 1;164(5):647-52 PMID: 14981093
  51. Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA.
    Genes Dev. 2004 Feb 15;18(4):387-96 PMID: 14977919
  52. T-loops and the origin of telomeres.
    Nat Rev Mol Cell Biol. 2004 Apr;5(4):323-9 PMID: 15071557
  53. The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins.
    BMC Bioinformatics. 2003 Oct 16;4:49 PMID: 14563212
  54. Holoenzyme proteins required for the physiological assembly and activity of telomerase.
    Genes Dev. 2004 May 15;18(10):1107-18 PMID: 15131081
  55. Regulation of telomerase by telomeric proteins.
    Annu Rev Biochem. 2004;73:177-208 PMID: 15189140
  56. Yeast telomerase RNA: a flexible scaffold for protein subunits.
    Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10024-9 PMID: 15226497
  57. Adding to the ends: what makes telomerase processive and how important is it?
    Bioessays. 2004 Sep;26(9):955-62 PMID: 15351966
  58. Telomerase RNA deficiency in peripheral blood mononuclear cells in X-linked dyskeratosis congenita.
    Hum Genet. 2004 Oct;115(5):448-55 PMID: 15349768
  59. An emerging consensus for telomerase RNA structure.
    Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14683-4 PMID: 15466703
  60. Evidence for reassociation of RNA-binding proteins after cell lysis: implications for the interpretation of immunoprecipitation analyses.
    RNA. 2004 Nov;10(11):1692-4 PMID: 15388877
  61. tRNA maturation: RNA polymerization without a nucleic acid template.
    Curr Biol. 2004 Oct 26;14(20):R883-5 PMID: 15498478
  62. A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena.
    J Mol Biol. 1978 Mar 25;120(1):33-53 PMID: 642006
  63. DNA sequences of telomeres maintained in yeast.
    Nature. 1984 Jul 12-18;310(5973):154-7 PMID: 6330571
  64. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
    Cell. 1985 Dec;43(2 Pt 1):405-13 PMID: 3907856
  65. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity.
    Cell. 1987 Dec 24;51(6):887-98 PMID: 3319189
  66. Telomere terminal transferase activity in the hypotrichous ciliate Oxytricha nova and a model for replication of the ends of linear DNA molecules.
    Nucleic Acids Res. 1988 Jul 25;16(14B):6953-72 PMID: 3136437
  67. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
    Proc Natl Acad Sci U S A. 1988 Sep;85(18):6622-6 PMID: 3413114
  68. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.
    Nature. 1989 Jan 26;337(6205):331-7 PMID: 2463488
  69. A mutant with a defect in telomere elongation leads to senescence in yeast.
    Cell. 1989 May 19;57(4):633-43 PMID: 2655926
  70. Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers.
    Mol Cell Biol. 1989 Jun;9(6):2761-4 PMID: 2474761
  71. Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
    Proc Natl Acad Sci U S A. 1989 Sep;86(18):7049-53 PMID: 2780561
  72. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.
    Cell. 1989 Nov 3;59(3):521-9 PMID: 2805070
  73. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs.
    Nature. 1990 Mar 8;344(6262):126-32 PMID: 1689810
  74. Inhibition of telomerase by G-quartet DNA structures.
    Nature. 1991 Apr 25;350(6320):718-20 PMID: 2023635
  75. Developmentally programmed healing of chromosomes by telomerase in Tetrahymena.
    Cell. 1991 Nov 15;67(4):823-32 PMID: 1934071
  76. Telomere loss: mitotic clock or genetic time bomb?
    Mutat Res. 1991 Mar-Nov;256(2-6):271-82 PMID: 1722017
  77. TLC1: template RNA component of Saccharomyces cerevisiae telomerase.
    Science. 1994 Oct 21;266(5184):404-9 PMID: 7545955
  78. Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates.
    J Cell Biol. 1995 Jul;130(2):243-53 PMID: 7615628
  79. Telomerase in yeast.
    Science. 1995 Jul 21;269(5222):396-400 PMID: 7618104
  80. The RNA component of human telomerase.
    Science. 1995 Sep 1;269(5228):1236-41 PMID: 7544491
  81. Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang.
    Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10712-7 PMID: 8855245
  82. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.
    Genetics. 1996 Dec;144(4):1399-412 PMID: 8978029
  83. Reverse transcriptase motifs in the catalytic subunit of telomerase.
    Science. 1997 Apr 25;276(5312):561-7 PMID: 9110970
  84. Variable telomeric repeat synthesis in Paramecium tetraurelia is consistent with misincorporation by telomerase.
    EMBO J. 1997 Jun 2;16(11):3233-42 PMID: 9214639
  85. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity.
    Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11190-5 PMID: 9326584
  86. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.
    Hum Mol Genet. 1997 Nov;6(12):2011-9 PMID: 9328464
  87. Functionally interacting telomerase RNAs in the yeast telomerase complex.
    Genes Dev. 1997 Nov 1;11(21):2790-800 PMID: 9353249
  88. Human telomerase contains evolutionarily conserved catalytic and structural subunits.
    Genes Dev. 1997 Dec 1;11(23):3109-15 PMID: 9389643
  89. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT.
    Nat Genet. 1997 Dec;17(4):498-502 PMID: 9398860
  90. Polyadenylation of telomerase RNA in budding yeast.
    RNA. 1997 Nov;3(11):1337-51 PMID: 9409624
  91. A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase.
    EMBO J. 1998 Feb 16;17(4):1152-60 PMID: 9463392
  92. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase.
    Nat Genet. 1998 Jun;19(2):199-202 PMID: 9620782
  93. The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex.
    Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8485-90 PMID: 9671704
  94. Expression of mouse telomerase catalytic subunit in embryos and adult tissues.
    Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10471-6 PMID: 9724727
  95. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end.
    Mol Cell Biol. 1999 Jan;19(1):567-76 PMID: 9858580
  96. Functional requirement of p23 and Hsp90 in telomerase complexes.
    Genes Dev. 1999 Apr 1;13(7):817-26 PMID: 10197982
  97. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle.
    Nature. 1999 Sep 9;401(6749):177-80 PMID: 10490028
  98. Nucleolin interacts with telomerase.
    J Biol Chem. 2004 Dec 3;279(49):51508-15 PMID: 15371412
  99. Cell cycle-dependent regulation of yeast telomerase by Ku.
    Nat Struct Mol Biol. 2004 Dec;11(12):1198-205 PMID: 15531893
  100. Heterozygous telomerase RNA mutations found in dyskeratosis congenita and aplastic anemia reduce telomerase activity via haploinsufficiency.
    Blood. 2004 Dec 15;104(13):3936-42 PMID: 15319288
  101. Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR.
    J Biol Chem. 2004 Dec 10;279(50):51745-8 PMID: 15381700
  102. A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase.
    Nat Struct Mol Biol. 2005 Mar;12(3):252-7 PMID: 15696174
  103. Functional characterization of telomerase RNA variants found in patients with hematologic disorders.
    Blood. 2005 Mar 15;105(6):2332-9 PMID: 15550482
  104. Telomere length regulation during cloning, embryogenesis and ageing.
    Reprod Fertil Dev. 2005;17(1-2):85-96 PMID: 15745634
  105. Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.
    Genes Dev. 2005 Apr 1;19(7):776-81 PMID: 15805468
  106. Telomerase: regulation, function and transformation.
    Crit Rev Oncol Hematol. 2005 May;54(2):85-93 PMID: 15843091
  107. Senescence and immortalization: role of telomeres and telomerase.
    Carcinogenesis. 2005 May;26(5):867-74 PMID: 15471900
  108. Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting.
    EMBO J. 2000 Nov 15;19(22):6230-9 PMID: 11080168
  109. The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.
    Nat Genet. 2001 Jan;27(1):64-7 PMID: 11138000
  110. The Tetrahymena p80/p95 complex is required for proper telomere length maintenance and micronuclear genome stability.
    Mol Cell. 2000 Oct;6(4):827-37 PMID: 11090621
  111. RNA binding domain of telomerase reverse transcriptase.
    Mol Cell Biol. 2001 Feb;21(4):990-1000 PMID: 11158287
  112. Major cutbacks at chromosome ends.
    Trends Biochem Sci. 2005 Jul;30(7):388-95 PMID: 15936947
  113. Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation.
    J Immunol. 2001 Apr 15;166(8):4826-30 PMID: 11290757
  114. Telomerase can act as a template- and RNA-independent terminal transferase.
    Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9778-83 PMID: 15994230
  115. Cell biology: Shaggy mouse tales.
    Nature. 2005 Aug 18;436(7053):922-3 PMID: 16107824
  116. LSm proteins form heptameric rings that bind to RNA via repeating motifs.
    Trends Biochem Sci. 2005 Sep;30(9):522-8 PMID: 16051491
  117. Telomeres and human disease: ageing, cancer and beyond.
    Nat Rev Genet. 2005 Aug;6(8):611-22 PMID: 16136653
  118. Shelterin: the protein complex that shapes and safeguards human telomeres.
    Genes Dev. 2005 Sep 15;19(18):2100-10 PMID: 16166375
  119. Telomerase and Cancer: Kirk A. Landon--AACR prize for basic cancer research lecture.
    Mol Cancer Res. 2005 Sep;3(9):477-82 PMID: 16179494
  120. Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo.
    Nat Struct Mol Biol. 2005 Oct;12(10):847-54 PMID: 16142245
  121. Dyskeratosis congenita: a disorder of defective telomere maintenance?
    Int J Hematol. 2005 Oct;82(3):184-9 PMID: 16207588
  122. Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells.
    Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14398-403 PMID: 16172394
  123. Cajal bodies: a long history of discovery.
    Annu Rev Cell Dev Biol. 2005;21:105-31 PMID: 16212489
  124. RNA-guided DNA deletion in Tetrahymena: an RNAi-based mechanism for programmed genome rearrangements.
    Annu Rev Genet. 2005;39:537-59 PMID: 16285871
  125. Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres.
    Mol Biol Cell. 2006 Feb;17(2):944-54 PMID: 16319170
  126. Cell cycle-regulated trafficking of human telomerase to telomeres.
    Mol Biol Cell. 2006 Feb;17(2):955-65 PMID: 16339074
  127. Telomere dynamics in genome stability.
    Trends Biochem Sci. 2006 Feb;31(2):114-22 PMID: 16406636
  128. A novel RNA binding domain in tetrahymena telomerase p65 initiates hierarchical assembly of telomerase holoenzyme.
    Mol Cell Biol. 2006 Mar;26(6):2029-36 PMID: 16507983
  129. Human telomerase and Cajal body ribonucleoproteins share a unique specificity of Sm protein association.
    Genes Dev. 2006 Mar 1;20(5):531-6 PMID: 16481465
  130. Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
    Nat Struct Mol Biol. 2006 Mar;13(3):218-25 PMID: 16462747
  131. Extension of G-quadruplex DNA by ciliate telomerase.
    EMBO J. 2006 Mar 8;25(5):1148-59 PMID: 16511573
  132. Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentation.
    Blood. 2006 Apr 1;107(7):2680-5 PMID: 16332973
  133. hnRNP A1 associates with telomere ends and stimulates telomerase activity.
    RNA. 2006 Jun;12(6):1116-28 PMID: 16603717
  134. The structure and function of telomerase reverse transcriptase.
    Annu Rev Biochem. 2006;75:493-517 PMID: 16756500
  135. Structure and function of telomerase RNA.
    Curr Opin Struct Biol. 2006 Jun;16(3):307-18 PMID: 16713250
  136. Telomerase RNA mutated in autosomal dyskeratosis congenita reconstitutes a weakly active telomerase enzyme defective in telomere elongation.
    Cell Cycle. 2005 Apr;4(4):585-9 PMID: 15753647
  137. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants.
    Genes Dev. 1999 Nov 1;13(21):2863-74 PMID: 10557213
  138. A telomerase component is defective in the human disease dyskeratosis congenita.
    Nature. 1999 Dec 2;402(6761):551-5 PMID: 10591218
  139. Identification of two RNA-binding proteins associated with human telomerase RNA.
    Mol Biol Cell. 2000 Mar;11(3):999-1010 PMID: 10712515
  140. In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs.
    Mol Cell Biol. 2000 May;20(9):3037-48 PMID: 10757788
  141. Template boundary in a yeast telomerase specified by RNA structure.
    Science. 2000 May 5;288(5467):863-7 PMID: 10797010
  142. Interference footprinting analysis of telomerase elongation complexes.
    Mol Cell Biol. 2000 Jun;20(12):4224-37 PMID: 10825187
  143. Involvement of 14-3-3 proteins in nuclear localization of telomerase.
    EMBO J. 2000 Jun 1;19(11):2652-61 PMID: 10835362
  144. Ciliate telomerase biochemistry.
    Annu Rev Biochem. 1999;68:187-218 PMID: 10872448
  145. The Est3 protein is a subunit of yeast telomerase.
    Curr Biol. 2000 Jun 29;10(13):809-12 PMID: 10898986
  146. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase.
    Mol Cell. 2000 Aug;6(2):361-71 PMID: 10983983
  147. Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo.
    Mol Cell Biol. 2000 Nov;20(21):8178-84 PMID: 11027287
  148. Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10.
    Mol Cell Biol. 2000 Dec;20(23):9028-40 PMID: 11074001
  149. Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase.
    Mol Cell Biol. 2000 Dec;20(23):9084-91 PMID: 11074006
  150. Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.
    Genes Dev. 2003 Oct 1;17(19):2384-95 PMID: 12975323
  151. Template boundary definition in mammalian telomerase.
    Genes Dev. 2003 Nov 15;17(22):2747-52 PMID: 14630939
  152. Tetrahymena telomerase is active as a monomer.
    Mol Biol Cell. 2003 Dec;14(12):4794-804 PMID: 13679509
  153. Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate.
    J Biol Chem. 2003 Dec 26;278(52):52531-6 PMID: 14565961
  154. Biological and biochemical functions of RNA in the tetrahymena telomerase holoenzyme.
    Mol Cell Biol. 2005 Jun;25(11):4442-54 PMID: 15899850
  155. Ro's role in RNA reconnaissance.
    Cell. 2005 May 20;121(4):495-6 PMID: 15907458
  156. Dyskeratosis congenita -- a disease of dysfunctional telomere maintenance.
    Curr Mol Med. 2005 Mar;5(2):159-70 PMID: 15974869
  157. An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization.
    Mol Biol Cell. 2005 Jul;16(7):3152-61 PMID: 15857955
  158. Telomeres, stem cells, senescence, and cancer.
    J Clin Invest. 2004 Jan;113(2):160-8 PMID: 14722605
  159. A physical and functional constituent of telomerase anchor site.
    J Biol Chem. 2005 Jul 15;280(28):26586-91 PMID: 15905172
Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0072
DOI
10.1038/nrm1961
Email
kcollins@berkeley.edu
Published
2006-07-00
Pages
484-94
Language
English
Region
England
NLM ID
100962782
PMCID
PMC2915765
Subset
IM
Grants
NIGMS NIH HHS · R01 GM054198 · United States
NIGMS NIH HHS · R01 GM054198-10A1 · United States
NHLBI NIH HHS · R01 HL079585 · United States
External Links
PubMed source DOI: 10.1038/nrm1961 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2