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PMID: 2463488 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.

Nature ·Vol. 337 ·No. 6205 ·1989-01-26 ·Pages 331-7

Greider CW, Blackburn EH

Abstract

The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

MeSH Terms

Animals Base Sequence Chromosomes/physiology Cloning, Molecular DNA/genetics DNA Nucleotidylexotransferase/genetics Genes Molecular Sequence Data Oligonucleotide Probes RNA/genetics Repetitive Sequences, Nucleic Acid Tetrahymena/enzymology,genetics

Chemicals

Oligonucleotide Probes RNA DNA DNA Nucleotidylexotransferase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Greider C W

Cold Spring Harbor Laboratory, New York 11724.

Blackburn E H

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/337331a0

Published

1989-01-26

Pages

331-7

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/337331a0 View journal details

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A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.

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