-
Telomere maintenance by recombination in human cells.
Nat Genet. 2000 Dec;26(4):447-50
PMID: 11101843
-
Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body.
Cancer Res. 1999 Sep 1;59(17):4175-9
PMID: 10485449
-
Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells.
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4498-503
PMID: 11287649
-
Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells.
Mol Cell Biol. 2001 Jun;21(12):3862-75
PMID: 11359895
-
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.
EMBO J. 2001 Jun 1;20(11):2619-30
PMID: 11387197
-
Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas.
Oncogene. 2001 Jun 28;20(29):3835-44
PMID: 11439347
-
Telomere maintenance by telomerase and by recombination can coexist in human cells.
Hum Mol Genet. 2001 Sep 1;10(18):1945-52
PMID: 11555631
-
Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.
EMBO Rep. 2001 Sep;2(9):800-7
PMID: 11520856
-
Switching and signaling at the telomere.
Cell. 2001 Sep 21;106(6):661-73
PMID: 11572773
-
The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability.
Cell. 2001 Oct 5;107(1):67-77
PMID: 11595186
-
Alternative lengthening of telomeres in mammalian cells.
Oncogene. 2002 Jan 21;21(4):598-610
PMID: 11850785
-
Constitutive telomerase expression promotes mammary carcinomas in aging mice.
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8191-6
PMID: 12034875
-
Connecting chromosomes, crisis, and cancer.
Science. 2002 Jul 26;297(5581):565-9
PMID: 12142527
-
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism.
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12606-11
PMID: 12193655
-
Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen.
Exp Cell Res. 1989 Sep;184(1):109-18
PMID: 2551703
-
A role for both RB and p53 in the regulation of human cellular senescence.
Exp Cell Res. 1991 Sep;196(1):33-9
PMID: 1652450
-
Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.
Biochem Biophys Res Commun. 1991 Aug 30;179(1):528-34
PMID: 1909121
-
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
EMBO J. 1992 May;11(5):1921-9
PMID: 1582420
-
The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen.
Exp Cell Res. 1993 Nov;209(1):45-52
PMID: 8224005
-
Telomere dynamics in an immortal human cell line.
EMBO J. 1994 Oct 17;13(20):4953-62
PMID: 7957062
-
Specific association of human telomerase activity with immortal cells and cancer.
Science. 1994 Dec 23;266(5193):2011-5
PMID: 7605428
-
Telomerase activity in normal and malignant hematopoietic cells.
Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9082-6
PMID: 7568077
-
Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis.
Nat Genet. 1996 Feb;12(2):200-4
PMID: 8563761
-
Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.
Mol Cell Biol. 1996 Jul;16(7):3765-72
PMID: 8668193
-
Heterogeneity in telomere length of human chromosomes.
Hum Mol Genet. 1996 May;5(5):685-91
PMID: 8733138
-
Telomerase catalytic subunit homologs from fission yeast and human.
Science. 1997 Aug 15;277(5328):955-9
PMID: 9252327
-
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.
Cell. 1997 Aug 22;90(4):785-95
PMID: 9288757
-
Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines.
Nat Med. 1997 Nov;3(11):1271-4
PMID: 9359704
-
Extension of life-span by introduction of telomerase into normal human cells.
Science. 1998 Jan 16;279(5349):349-52
PMID: 9454332
-
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span.
Curr Biol. 1998 Feb 26;8(5):279-82
PMID: 9501072
-
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization.
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14723-8
PMID: 9843956
-
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse.
Cell. 1999 May 14;97(4):515-25
PMID: 10338215
-
The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis.
J Neurochem. 2000 Jul;75(1):117-24
PMID: 10854254
-
Creation of human tumour cells with defined genetic elements.
Nature. 1999 Jul 29;400(6743):464-8
PMID: 10440377