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PMID: 1663787 Published · ppublish English Journal Article Review

Protein phosphatases and DNA tumor viruses: transformation through the back door?

Cell regulation ·Vol. 2 ·No. 8 ·1991-08-00 ·Pages 589-98

Mumby MC, Walter G

Abstract

Cellular transformation by many oncogenic viruses is mediated by alterations in signal transduction pathways that control normal growth and proliferation. Common targets for many transforming viruses are pathways regulated by protein phosphorylation. The biochemical control of proteins in these pathways is a dynamic process that is regulated by the relative activities of protein kinases and phosphatases. Although there are numerous examples of viral oncogenes that encode protein kinases (Hunter, 1991), until recently there has been no evidence linking altered phosphatase activity to transformation. In this review we describe a novel mechanism, utilized by small DNA tumor viruses, in which viral oncogenes bind to and regulate a cellular protein serine/threonine phosphatase. The currently available evidence indicates that alteration of phosphatase activity and subsequent changes in phosphorylation levels is an important step in transformation by these viruses.

MeSH Terms
Antigens, Neoplasm/metabolism Cell Transformation, Viral/genetics DNA Tumor Viruses/genetics Oncogenes Phosphoprotein Phosphatases/antagonists & inhibitors,metabolism,physiology Phosphorylation Signal Transduction
Chemicals
Antigens, Neoplasm Phosphoprotein Phosphatases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mumby M C
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235-9041.
Walter G
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Article Info
Journal
Cell regulation
Abbr.
Cell Regul
ISSN
1044-2030
DOI
10.1091/mbc.2.8.589
Published
1991-08-00
Pages
589-98
Language
English
Region
United States
NLM ID
9005331
PMCID
PMC361850
Subset
IM
External Links
PubMed source DOI: 10.1091/mbc.2.8.589 PMC Full Text
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