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PMID: 2987540 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Simian virus 40 small-t antigen-induced theophylline resistance is not mediated by cyclic AMP.

Journal of virology ·Vol. 54 ·No. 3 ·1985-06-00 ·Pages 876-8

Renz C, Rundell K

Abstract

Small-t antigen of simian virus 40 renders CV-1 cells resistant to growth arrest induced by theophylline and other methylxanthines. Elevated levels of cyclic AMP are not involved in growth arrest of CV-1 cells by methylxanthines, and small-t antigen does not alter cyclic AMP levels dramatically after infection.

MeSH Terms
Animals Antigens, Polyomavirus Transforming Antigens, Viral, Tumor/pharmacology Cells, Cultured Colforsin Cyclic AMP/analysis,physiology Diterpenes/pharmacology Drug Resistance Protein Kinases/analysis Theophylline/pharmacology Viral Proteins/pharmacology
Chemicals
Antigens, Polyomavirus Transforming Antigens, Viral, Tumor Diterpenes Viral Proteins Colforsin Theophylline Cyclic AMP Protein Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Renz C
Rundell K
References (25)
25 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.54.3.876-878.1985
Published
1985-06-00
Pages
876-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254879
Subset
IM
Grants
NCI NIH HHS · CA 21327 · United States
External Links
PubMed source DOI: 10.1128/JVI.54.3.876-878.1985 PMC Full Text View journal details
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