Cyclic nucleotide phosphodiesterases: properties, activators, inhibitors, structure--activity relationships, and possible role in drug development.

Animals Anticoagulants/pharmacology Benzothiadiazines/pharmacology Catecholamines/pharmacology Cell Line Cyclic AMP Cyclic GMP Disease/enzymology Diuretics/pharmacology Enzyme Activation Heterocyclic Compounds/pharmacology Hormones/pharmacology Humans Imidazoles/pharmacology Indoles/pharmacology Isoquinolines/pharmacology Nucleotides/metabolism Papaverine/pharmacology Phosphodiesterase Inhibitors Phosphoric Diester Hydrolases/isolation & purification Psychotropic Drugs/pharmacology Pyridines/pharmacology Quinolines/pharmacology Species Specificity Structure-Activity Relationship Sulfhydryl Reagents/pharmacology Sulfonylurea Compounds/pharmacology Xanthines/pharmacology

Anticoagulants Benzothiadiazines Catecholamines Diuretics Heterocyclic Compounds Hormones Imidazoles Indoles Isoquinolines Nucleotides Phosphodiesterase Inhibitors Psychotropic Drugs Pyridines Quinolines Sulfhydryl Reagents Sulfonylurea Compounds Xanthines Papaverine Cyclic AMP Phosphoric Diester Hydrolases Cyclic GMP