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PMID: 6690714 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Reversal of simian virus 40 small-t-antigen-induced theophylline resistance.

Journal of virology ·Vol. 49 ·No. 1 ·1984-01-00 ·Pages 262-4

Rundell K, Calenoff M, Renz C

Abstract

Simian virus 40 small-t antigen allows the growth of CV-1 cells in concentrations of theophylline that normally prevent cell cycling. This effect is completely overcome by two ionophores that uncouple mitochondria and by the anti-mitochondrial drug methylglyoxal bis-(guanylhydrazone).

MeSH Terms

Antigens, Viral, Tumor Cell Cycle/drug effects Cells, Cultured Drug Resistance, Microbial Mitochondria/physiology Polyamines/pharmacology Potassium/metabolism Theophylline/pharmacology Uncoupling Agents

Chemicals

Antigens, Viral, Tumor Polyamines Uncoupling Agents Theophylline Potassium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Rundell K

Calenoff M

Renz C

References (16)

16 references, click to expand

The antimitochondrial action of 2-choloro-4', 4"-bis(2-imidazolin-2-yl)terephthalanilide and methylglyoxal bis(guanylhydrazone).
Cancer Res. 1966 Jan;26(1):18-25 PMID: 5901744
Mutational analysis of simian virus 40 T antigen: stimulation of cellular DNA synthesis and activation of rRNA genes by mutants with deletions in the T-antigen gene.
Mol Cell Biol. 1983 Feb;3(2):214-9 PMID: 6300657
S-adenosyl-L-methionine decarboxylase during lymphocyte transformation: decreased degradation in the presence of a specific inhibitor.
Biochem Biophys Res Commun. 1973 Jun 8;52(3):1020-5 PMID: 4736320
Membrane potential and neutral amino acid transport in plasma membrane vesicles from Simian virus 40 transformed mouse fibroblasts.
Biochemistry. 1977 Sep 20;16(19):4328-34 PMID: 197993
Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells.
Cell. 1978 May;14(1):79-88 PMID: 208777
New region of the simian virus 40 genome required for efficient viral transformation.
Proc Natl Acad Sci U S A. 1978 May;75(5):2473-7 PMID: 209467
Serum stimulates the Na+,K+ pump in quiescent fibroblasts by increasing Na+ entry.
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5560-4 PMID: 82969
The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells.
Cell. 1979 Jul;17(3):635-43 PMID: 225037
Simian virus 40 t antigen affects the sensitivity of cellular DNA synthesis to theophylline.
J Virol. 1979 Apr;30(1):394-6 PMID: 225524
Cellular proteins associated with simian virus 40 early gene products in newly infected cells.
J Virol. 1979 Oct;32(1):147-54 PMID: 232167
Simian virus 40 small-t protein is required for loss of actin cable networks in rat cells.
J Virol. 1980 Mar;33(3):1182-91 PMID: 6245268
The influence of an uncoupler on amino acid accumulation in Ehrlich mouse ascites tumor cells.
Biochim Biophys Acta. 1980 Sep 18;601(2):403-14 PMID: 7407176
Actions of bis(guanylhydrazones) on isolated rat liver mitochondria.
Biochem Pharmacol. 1981 Oct;30(20):2851-60 PMID: 6895596
Mitochondria are associated with microtubules and not with intermediate filaments in cultured fibroblasts.
Proc Natl Acad Sci U S A. 1982 Jan;79(1):123-6 PMID: 6275382
Putative association of mitochondria with a subpopulation of intermediate-sized filaments in cultured human skin fibroblasts.
Cell. 1982 Dec;31(3 Pt 2):681-92 PMID: 6186387
Selective extraction of polyoma DNA from infected mouse cell cultures.
J Mol Biol. 1967 Jun 14;26(2):365-9 PMID: 4291934

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.49.1.262-264.1984

Published

1984-01-00

Pages

262-4

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC255450

Subset

Grants

NCI NIH HHS · CA 21327 · United States

External Links

PubMed source DOI: 10.1128/JVI.49.1.262-264.1984 PMC Full Text View journal details

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Reversal of simian virus 40 small-t-antigen-induced theophylline resistance.

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