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PMID: 1545809 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Embryonal long terminal repeat-binding protein is a murine homolog of FTZ-F1, a member of the steroid receptor superfamily.

Molecular and cellular biology ·Vol. 12 ·No. 3 ·1992-03-00 ·Pages 1286-91

Tsukiyama T, Ueda H, Hirose S, Niwa O

Abstract

The embryonal long terminal repeat-binding protein, ELP, is present in undifferentiated mouse embryonal carcinoma cells. It binds to and suppresses transcription of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. We report here that ELP is a mouse homolog of Drosophila FTZ-F1, which positively regulates transcription of the fushi tarazu gene in blastoderm-stage embryos of the fly. As members of the steroid receptor superfamily, ELP and FTZ-F1 have both DNA binding and putative ligand binding domains which are well conserved between the two. ELP and FTZ-F1 function in cells in the extremely early stage of development. A high degree of conservation between the two transcription factors during the evolution of these species indicates the importance of their functions in early-stage embryogenesis. In addition, the sequence elements they recognize do not contain repeat units, in contrast to other steroid receptors, which usually bind to either palindromic or direct repeat sequences.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Bombyx Cell Line DNA DNA-Binding Proteins/genetics,metabolism Drosophila Drosophila Proteins Fushi Tarazu Transcription Factors Homeodomain Proteins Insect Hormones/genetics,metabolism Mice Molecular Sequence Data Receptors, Steroid/genetics,metabolism Repetitive Sequences, Nucleic Acid Sequence Homology, Nucleic Acid
Chemicals
DNA-Binding Proteins Drosophila Proteins Fushi Tarazu Transcription Factors Homeodomain Proteins Insect Hormones Receptors, Steroid ftz protein, Drosophila DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Tsukiyama T
Department of Pathology, Hiroshima University, Japan.
Ueda H
Hirose S
Niwa O
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.12.3.1286-1291.1992
Published
1992-03-00
Pages
1286-91
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC369561
Subset
IM
Databases
GENBANK
D90530
External Links
PubMed source DOI: 10.1128/mcb.12.3.1286-1291.1992 PMC Full Text View journal details
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