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PMID: 1972777 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.

Nature ·Vol. 345 ·No. 6277 ·1990-06-21 ·Pages 686-92

Rosner MH, Vigano MA, Ozato K, Timmons PM, Poirier F, Rigby PW, Staudt LM

Abstract

The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.

MeSH Terms

Amino Acid Sequence Base Sequence Cell Differentiation DNA-Binding Proteins/genetics Down-Regulation Embryo, Mammalian/metabolism Embryo, Nonmammalian Endoderm/cytology Gene Expression Genes, Homeobox Germ Cells/metabolism Mesoderm/cytology Molecular Sequence Data Nucleic Acid Hybridization Octamer Transcription Factor-3 Oocytes/growth & development,metabolism RNA, Messenger/analysis,genetics Stem Cells/metabolism Transcription Factors/genetics

Chemicals

DNA-Binding Proteins Octamer Transcription Factor-3 RNA, Messenger Transcription Factors

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Rosner M H

Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892.

Vigano M A

Ozato K

Timmons P M

Poirier F

Rigby P W

Staudt L M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/345686a0

Published

1990-06-21

Pages

686-92

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/345686a0 View journal details

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A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.

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