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PMID: 12966141 Published · ppublish English Journal Article Review

Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin.

Microbiology and molecular biology reviews : MMBR ·Vol. 67 ·No. 3 ·2003-09-00 ·Pages 376-99, table of contents

Bitterman KJ, Medvedik O, Sinclair DA

Abstract

When it was first proposed that the budding yeast Saccharomyces cerevisiae might serve as a model for human aging in 1959, the suggestion was met with considerable skepticism. Although yeast had proved a valuable model for understanding basic cellular processes in humans, it was difficult to accept that such a simple unicellular organism could provide information about human aging, one of the most complex of biological phenomena. While it is true that causes of aging are likely to be multifarious, there is a growing realization that all eukaryotes possess surprisingly conserved longevity pathways that govern the pace of aging. This realization has come, in part, from studies of S. cerevisiae, which has emerged as a highly informative and respected model for the study of life span regulation. Genomic instability has been identified as a major cause of aging, and over a dozen longevity genes have now been identified that suppress it. Here we present the key discoveries in the yeast-aging field, regarding both the replicative and chronological measures of life span in this organism. We discuss the implications of these findings not only for mammalian longevity but also for other key aspects of cell biology, including cell survival, the relationship between chromatin structure and genome stability, and the effect of internal and external environments on cellular defense pathways. We focus on the regulation of replicative life span, since recent findings have shed considerable light on the mechanisms controlling this process. We also present the specific methods used to study aging and longevity regulation in S. cerevisiae.

MeSH Terms
Gene Expression Regulation, Fungal Genome, Fungal Heterochromatin/genetics,physiology Histone Deacetylases/genetics,physiology Longevity/genetics,physiology Models, Molecular Saccharomyces cerevisiae/genetics,metabolism,physiology Silent Information Regulator Proteins, Saccharomyces cerevisiae/genetics,physiology Sirtuin 2 Sirtuins/genetics,physiology
Chemicals
Heterochromatin Silent Information Regulator Proteins, Saccharomyces cerevisiae SIR2 protein, S cerevisiae Sirtuin 2 Sirtuins Histone Deacetylases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bitterman Kevin J
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Medvedik Oliver
Sinclair David A
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1092-2172
DOI
10.1128/MMBR.67.3.376-399.2003
Published
2003-09-00
Pages
376-99, table of contents
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC193872
Subset
IM
Grants
NIA NIH HHS · P01 AG027916-030003 · United States
NIA NIH HHS · P01 AG027916-020003 · United States
NIA NIH HHS · P01 AG027916-010003 · United States
NIA NIH HHS · P01 AG027916-04S20003 · United States
NIA NIH HHS · R01 AG019719-06A1 · United States
NIA NIH HHS · R01 AG028730-03 · United States
NIA NIH HHS · P01 AG027916 · United States
NIA NIH HHS · P01 AG027916-04S10003 · United States
NIA NIH HHS · R01 AG028730 · United States
NIA NIH HHS · R01 AG019719-07 · United States
NIA NIH HHS · R01 AG028730-02 · United States
NIA NIH HHS · R01 AG028730-01A1 · United States
NIA NIH HHS · P01 AG027916-040003 · United States
NIA NIH HHS · R01 AG019719 · United States
External Links
PubMed source DOI: 10.1128/MMBR.67.3.376-399.2003 PMC Full Text View journal details
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