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PMID: 12952077 Published · ppublish English Journal Article Review

cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection.

Journal of muscle research and cell motility ·Vol. 23 ·No. 7-8 ·2002-00-00 ·Pages 793-802

Saran S, Meima ME, Alvarez-Curto E, Weening KE, Rozen DE, Schaap P

Abstract

cAMP plays a pivotal role in control of cell movement, differentiation and response to stress in all phases of the Dictyostelium life cycle. The multitudinous functions of cAMP require precise spatial and temporal control of its production, degradation and detection. Many novel proteins have recently been identified that critically modulate the cAMP signal. We focus in this review on the properties and functions of the three adenylyl cyclases and the three cAMP-phosphodiesterases that are present in Dictyostelium, and the network of proteins that regulate the activity of these enzymes. We also briefly discuss the two modes of detection of cAMP.

MeSH Terms
Adenylyl Cyclases/metabolism Animals Cyclic AMP/metabolism,physiology Cyclic AMP-Dependent Protein Kinases/genetics,metabolism Dictyostelium/physiology Gene Expression Regulation Models, Biological Phosphoric Diester Hydrolases/metabolism Protozoan Proteins/metabolism Signal Transduction/physiology Spores/physiology
Chemicals
Protozoan Proteins Cyclic AMP Cyclic AMP-Dependent Protein Kinases Phosphoric Diester Hydrolases Adenylyl Cyclases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Saran Shweta
School of Life Sciences, University of Dundee, MSI/WTB complex, Dundee DD1 5EH, UK.
Meima Marcel E
Alvarez-Curto Elisa
Weening Karin E
Rozen Daniel E
Schaap Pauline
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Article Info
Journal
Journal of muscle research and cell motility
Abbr.
J Muscle Res Cell Motil
ISSN
0142-4319
DOI
10.1023/a:1024483829878
Published
2002-00-00
Pages
793-802
Language
English
Region
Netherlands
NLM ID
8006298
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1024483829878 View journal details
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