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PMID: 11416179 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

All kinesin superfamily protein, KIF, genes in mouse and human.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 13 ·2001-06-19 ·Pages 7004-11

Miki H, Setou M, Kaneshiro K, Hirokawa N

Abstract

Intracellular transport is essential for morphogenesis and functioning of the cell. The kinesin superfamily proteins (KIFs) have been shown to transport membranous organelles and protein complexes in a microtubule- and ATP-dependent manner. More than 30 KIFs have been reported in mice. However, the nomenclature of KIFs has not been clearly established, resulting in various designations and redundant names for a single KIF. Here, we report the identification and classification of all KIFs in mouse and human genome transcripts. Previously unidentified murine KIFs were found by a PCR-based search. The identification of all KIFs was confirmed by a database search of the total human genome. As a result, there are a total of 45 KIFs. The nomenclature of all KIFs is presented. To understand the function of KIFs in intracellular transport in a single tissue, we focused on the brain. The expression of 38 KIFs was detected in brain tissue by Northern blotting or PCR using cDNA. The brain, mainly composed of highly differentiated and polarized cells such as neurons and glia, requires a highly complex intracellular transport system as indicated by the increased number of KIFs for their sophisticated functions. It is becoming increasingly clear that the cell uses a number of KIFs and tightly controls the direction, destination, and velocity of transportation of various important functional molecules, including mRNA. This report will set the foundation of KIF and intracellular transport research.

MeSH Terms
Animals Brain/metabolism Humans Kinesins/genetics,metabolism Mice Molecular Sequence Data Multigene Family Nerve Tissue Proteins/genetics,metabolism Organelles/metabolism Phylogeny Protein Transport Saccharomyces cerevisiae/genetics
Chemicals
Nerve Tissue Proteins Kinesins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Miki H
Department of Cell Biology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan.
Setou M
Kaneshiro K
Hirokawa N
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.111145398
Published
2001-06-19
Pages
7004-11
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC34614
Subset
IM
Databases
GENBANK
AB053955, AB054024, AB054025, AB054026, AB054027, AB054028, AB054029, AB054030, AB054031
External Links
PubMed source DOI: 10.1073/pnas.111145398 PMC Full Text View journal details
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