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PMID: 10837671 Published · ppublish English Journal Article

Mechanisms of enveloped virus entry into animal cells.

Advanced drug delivery reviews ·Vol. 34 ·No. 1 ·1998-10-05 ·Pages 65-91

Klasse PJ, Bron R, Marsh M

Abstract

The ability of viruses to transfer macromolecules between cells makes them attractive starting points for the design of biological delivery vehicles. Virus-based vectors and sub-viral systems are already finding biotechnological and medical applications for gene, peptide, vaccine and drug delivery. Progress has been made in understanding the cellular and molecular mechanisms underlying virus entry, particularly in identifying virus receptors. However, receptor binding is only a first step and we now have to understand how these molecules facilitate entry, how enveloped viruses fuse with cells or non-enveloped viruses penetrate the cell membrane, and what happens following penetration. Only through these detailed analyses will the full potential of viruses as vectors and delivery vehicles be realised. Here we discuss aspects of the entry mechanisms for several well-characterised viral systems. We do not attempt to provide a fully comprehensive review of virus entry but focus primarily on enveloped viruses.

Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Klasse
Medical Research Council Laboratory for Molecular Cell Biology, and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
Bron
Marsh
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Article Info
Journal
Advanced drug delivery reviews
Abbr.
Adv Drug Deliv Rev
ISSN
1872-8294
DOI
10.1016/s0169-409x(98)00002-7
Published
1998-10-05
Pages
65-91
Language
English
Region
Netherlands
NLM ID
8710523
PMCID
PMC7125647
External Links
PubMed source DOI: 10.1016/s0169-409x(98)00002-7 PMC Full Text View journal details
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