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PMID: 10754554 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Links between replication, recombination and genome instability in eukaryotes.

Trends in biochemical sciences ·Vol. 25 ·No. 4 ·2000-04-00 ·Pages 196-200

Flores-Rozas H, Kolodner RD

Abstract

Double-strand breaks in DNA can be repaired by homologous recombination including break-induced replication. In this reaction, the end of a broken DNA invades an intact chromosome and primes DNA replication resulting in the synthesis of an intact chromosome. Break-induced replication has also been suggested to cause different types of genome rearrangements.

MeSH Terms
DNA Damage DNA Replication Eukaryotic Cells Genome Recombination, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Flores-Rozas H
Ludwig Institute for Cancer Research, Cancer Center and Dept of Medicine, University of California-San Diego School of Medicine, La Jolla, CA 92093, USA.
Kolodner R D
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Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
DOI
10.1016/s0968-0004(00)01568-1
Published
2000-04-00
Pages
196-200
Language
English
Region
England
NLM ID
7610674
PMCID
PMC3635104
Subset
IM
Grants
NIGMS NIH HHS · GM26017 · United States
NIGMS NIH HHS · R37 GM026017 · United States
NIGMS NIH HHS · R01 GM026017 · United States
NIGMS NIH HHS · GM50006 · United States
NIGMS NIH HHS · R01 GM050006 · United States
External Links
PubMed source DOI: 10.1016/s0968-0004(00)01568-1 PMC Full Text View journal details
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