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PMID: 9810228 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

DNA end-joining: from yeast to man.

Trends in biochemical sciences ·Vol. 23 ·No. 10 ·1998-10-00 ·Pages 394-8

Critchlow SE, Jackson SP

Abstract

DNA non-homologous end-joining (NHEJ) is a crucial process that has been conserved highly throughout eukaryotic evolution. At its heart is a multiprotein complex containing the KU70-KU80 heterodimer. Recent work has identified additional proteins involved in this pathway, providing insights into the mechanism of NHEJ and revealing exciting links with the control of transcription, telomere length and chromatin structure.

MeSH Terms

Antigens, Nuclear DNA/genetics,metabolism DNA Helicases DNA Repair DNA, Fungal/metabolism DNA-Binding Proteins/metabolism Humans Ku Autoantigen Models, Biological Nuclear Proteins/metabolism Peptide Fragments Peptides/metabolism Pro-Opiomelanocortin/metabolism Recombination, Genetic Saccharomyces cerevisiae/metabolism Saccharomyces cerevisiae Proteins Telomere/metabolism

Chemicals

Antigens, Nuclear DNA, Fungal DNA-Binding Proteins Nuclear Proteins Peptide Fragments Peptides Saccharomyces cerevisiae Proteins high affinity DNA-binding factor, S cerevisiae joining peptide, pro-opiomelanocortin Pro-Opiomelanocortin DNA DNA Helicases XRCC5 protein, human Xrcc6 protein, human Ku Autoantigen

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Critchlow S E

Wellcome/CRC Institute, Cambridge, UK.

Jackson S P

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/s0968-0004(98)01284-5

Published

1998-10-00

Pages

394-8

Language

English

Region

England

NLM ID

7610674

Subset

External Links

PubMed source DOI: 10.1016/s0968-0004(98)01284-5 View journal details

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