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PMID: 10731134 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Comparative genomics of the eukaryotes.

Science (New York, N.Y.) ·Vol. 287 ·No. 5461 ·2000-03-24 ·Pages 2204-15

Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, Birney E, Boguski MS, Brody T, Brokstein P, Celniker SE, Chervitz SA, Coates D, Cravchik A, Gabrielian A, Galle RF, Gelbart WM, George RA, Goldstein LS, Gong F, Guan P, Harris NL, Hay BA, Hoskins RA, Li J, Li Z, Hynes RO, Jones SJ, Kuehl PM, Lemaitre B, Littleton JT, Morrison DK, Mungall C, O'Farrell PH, Pickeral OK, Shue C, Vosshall LB, Zhang J, Zhao Q, Zheng XH, Lewis S

Abstract

A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

MeSH Terms
Animals Apoptosis/genetics Biological Evolution Caenorhabditis elegans/chemistry,genetics,physiology Cell Adhesion/genetics Cell Cycle/genetics Drosophila melanogaster/chemistry,genetics,physiology Fungal Proteins/chemistry,genetics Genes, Duplicate Genetic Diseases, Inborn/genetics Genetics, Medical Genome Helminth Proteins/chemistry,genetics Humans Immunity/genetics Insect Proteins/chemistry,genetics Multigene Family Neoplasms/genetics Protein Structure, Tertiary Proteome Saccharomyces cerevisiae/chemistry,genetics,physiology Signal Transduction/genetics
Chemicals
Fungal Proteins Helminth Proteins Insect Proteins Proteome
Authors & Affiliations
50 authors, click to expand affiliations / ORCID
Rubin G M
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, Berkeley Drosophila Genome Project, University of California, Berkeley, CA 94720, USA.
Yandell M D
Wortman J R
Gabor Miklos G L
Nelson C R
Hariharan I K
Fortini M E
Li P W
Apweiler R
Fleischmann W
Cherry J M
Henikoff S
Skupski M P
Misra S
Ashburner M
Birney E
Boguski M S
Brody T
Brokstein P
Celniker S E
Chervitz S A
Coates D
Cravchik A
Gabrielian A
Galle R F
Gelbart W M
George R A
Goldstein L S
Gong F
Guan P
Harris N L
Hay B A
Hoskins R A
Li J
Li Z
Hynes R O
Jones S J
Kuehl P M
Lemaitre B
Littleton J T
Morrison D K
Mungall C
O'Farrell P H
Pickeral O K
Shue C
Vosshall L B
Zhang J
Zhao Q
Zheng X H
Lewis S
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.287.5461.2204
Published
2000-03-24
Pages
2204-15
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2754258
Subset
IM
Grants
NHGRI NIH HHS · P50HG00750 · United States
NIGMS NIH HHS · R01 GM037193 · United States
NIGMS NIH HHS · R01 GM060988-01 · United States
NIGMS NIH HHS · R01 GM060988 · United States
NIGMS NIH HHS · R01 GM037193-15 · United States
NHGRI NIH HHS · P4IHG00739 · United States
NINDS NIH HHS · R01 NS040296 · United States
NINDS NIH HHS · R01 NS040296-01 · United States
NIGMS NIH HHS · R01 GM037193-14 · United States
External Links
PubMed source DOI: 10.1126/science.287.5461.2204 PMC Full Text View journal details
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