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PMID: 10504201 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Molecular analysis of developmental plasticity in neocortex.

Journal of neurobiology ·Vol. 41 ·No. 1 ·1999-10-00 ·Pages 135-47

Nedivi E

Abstract

Gene expression studies indicate that during activity-dependent developmental plasticity, N-methyl-D-aspartate receptor activation causes a Ca(2+)-dependent increase in expression of transcription factors and their downstream targets. The products of these plasticity genes then operate collectively to bring about the structural and functional changes that underlie ocular dominance plasticity in visual cortex. Identifying and characterizing plasticity genes provides a tool for molecular dissection of the mechanisms involved. Members of second-messenger pathways identified in adult plasticity paradigms and elements of the transmission machinery are the first candidate plasticity genes tested for their role in activity-dependent developmental plasticity. Knockout mice with deletions of such genes have allowed analyzing their function in the context of different systems and in different paradigms. Studies of mutant mice reveal that activity-dependent plasticity is not necessarily a unified phenomenon. The relative importance of a gene can vary with the context of its expression during different forms of plasticity. Forward genetic screens provide additional new candidates for testing, some with well-defined cellular functions that provide insight into possible plasticity mechanisms.

MeSH Terms
Animals Brain Chemistry/genetics Gene Expression Regulation, Developmental Neocortex/growth & development,physiology Neuronal Plasticity/genetics
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Nedivi E
Department of Brain and Cognitive Sciences, Center for Learning and Memory, Massachusetts Institute of Technology, 45 Carleton St., E25-435, Cambridge, Massachusetts 02139, USA.
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Article Info
Journal
Journal of neurobiology
Abbr.
J Neurobiol
ISSN
0022-3034
Published
1999-10-00
Pages
135-47
Language
English
Region
United States
NLM ID
0213640
PMCID
PMC3062904
Subset
IM
Grants
NEI NIH HHS · R01 EY011894 · United States
NEI NIH HHS · R29 EY011894 · United States
NEI NIH HHS · R29 EY011894-05 · United States
NEI NIH HHS · EY11894 · United States
External Links
PubMed source PMC Full Text
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