Correlation in the discharges of neighboring rat retinal ganglion cells during prenatal life.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 7 ·1990-04-00 ·Pages 2861-4

Maffei L, Galli-Resta L

Abstract

The spontaneous discharges of neighboring retinal ganglion cells were recorded simultaneously in anesthetized prenatal rats between embryonic days 18 and 21. We report here that in the majority of cases the firings of neighboring retinal ganglion cells are strongly correlated during prenatal life. Correlation in the discharges of neighboring cells during development has long been suggested as a way to consolidate synaptic connections with a target cell onto which they converge, a model first proposed by Hebb. Correlation in the activities of neighboring neurons in the retina could be the basis of developmental processes such as refinement of retinotopic maps in the brain and segregation of the inputs from the two eyes.

MeSH Terms

Animals Cell Communication Embryonic and Fetal Development Fetus/physiology Rats Retina/embryology,physiology Retinal Ganglion Cells/physiology

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Maffei L

Istituto di Neurofisiologia, Consiglio Nazionale delle Ricerche, Italy.

Galli-Resta L

References (13)

13 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.87.7.2861

Published

1990-04-00

Pages

2861-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC53791

Subset

External Links

PubMed source DOI: 10.1073/pnas.87.7.2861 PMC Full Text View journal details

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Correlation in the discharges of neighboring rat retinal ganglion cells during prenatal life.

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