Home LiteratureArticle Details

PMID: 2874497 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The long and the short of long-term memory--a molecular framework.

Nature ·Vol. 322 ·No. 6078 ·1986-00-00 ·Pages 419-22

Goelet P, Castellucci VF, Schacher S, Kandel ER

Abstract

A single learning event initiates several memory processes with different time courses of retention. While short term memory involves covalent modification of pre-existing proteins, the finding that long-term memory requires the expression, during learning, of additional genes, makes it possible to analyse in molecular terms the induction and retention of long-term memory.

MeSH Terms

Animals Calcium/metabolism Gene Expression Regulation Humans Learning Memory Memory, Short-Term Neurotransmitter Agents/biosynthesis,physiology Phosphorylation Protein Kinases/metabolism Proto-Oncogenes RNA, Messenger/metabolism Synaptic Transmission Time Factors

Chemicals

Neurotransmitter Agents RNA, Messenger Protein Kinases Calcium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Goelet P

Castellucci V F

Schacher S

Kandel E R

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/322419a0

Published

1986-00-00

Pages

419-22

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/322419a0 View journal details

Analysis Services

The long and the short of long-term memory--a molecular framework.

Contact

WeChat Official Account