Home LiteratureArticle Details
PMID: 9765485 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro.

Journal of virology ·Vol. 72 ·No. 11 ·1998-11-00 ·Pages 9337-44

Zhang YJ, Dragic T, Cao Y, Kostrikis L, Kwon DS, Littman DR, KewalRamani VN, Moore JP

Abstract

We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. Most non-syncytium-inducing isolates could utilize only CCR5. All syncytium-inducing viruses used CXCR4, some also employed V28, and one (DH123) used CCR8 and APJ as well. A longitudinal series of HIV-1 subtype B isolates from an infected infant and its mother utilized Bonzo efficiently, as well as CCR5. The maternal isolates, which were syncytium inducing, also used CXCR4, CCR8, V28, and APJ.

MeSH Terms
Adult CD4-Positive T-Lymphocytes/virology Cell Line Female Genes, env Genetic Complementation Test HIV Infections/transmission,virology HIV-1/genetics,pathogenicity,physiology Humans Infant Infectious Disease Transmission, Vertical Male Pregnancy Receptors, CCR5/genetics,physiology Receptors, CXCR4/genetics,physiology Receptors, HIV/genetics,physiology Transfection Virus Replication
Chemicals
Receptors, CCR5 Receptors, CXCR4 Receptors, HIV
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Zhang Y J
Aaron Diamond AIDS Research Center, The Rockefeller University, New York University School of Medicine, New York, New York 10016, USA.
Dragic T
Cao Y
Kostrikis L
Kwon D S
Littman D R
KewalRamani V N
Moore J P
References (79)
79 references, click to expand
  1. HIV type 1 subtypes, coreceptor usage, and CCR5 polymorphism.
    AIDS Res Hum Retroviruses. 1997 Nov 1;13(16):1357-66 PMID: 9359654
  2. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression.
    Nat Med. 1997 Nov;3(11):1259-65 PMID: 9359702
  3. Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses.
    J Virol. 1997 Dec;71(12):8999-9007 PMID: 9371556
  4. The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains.
    J Biol Chem. 1998 Jan 2;273(1):386-91 PMID: 9417093
  5. Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry.
    J Virol. 1998 Jan;72(1):279-85 PMID: 9420225
  6. Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines.
    J Virol. 1998 Jan;72(1):396-404 PMID: 9420238
  7. A new classification for HIV-1.
    Nature. 1998 Jan 15;391(6664):240 PMID: 9440686
  8. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.
    J Biol Chem. 1998 Jan 16;273(3):1764-8 PMID: 9430724
  9. HIV entry and tropism: the chemokine receptor connection.
    AIDS. 1997;11 Suppl A:S3-16 PMID: 9451961
  10. Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage.
    J Virol. 1998 Mar;72(3):1876-85 PMID: 9499039
  11. Differences in chemokine coreceptor usage between genetic subtypes of HIV-1.
    Virology. 1998 Feb 15;241(2):181-8 PMID: 9499793
  12. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function.
    Curr Biol. 1997 Sep 1;7(9):652-60 PMID: 9285716
  13. Co-receptors for HIV-1 entry.
    Curr Opin Immunol. 1997 Aug;9(4):551-62 PMID: 9287172
  14. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells.
    Science. 1997 Sep 26;277(5334):2005-7 PMID: 9302298
  15. Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype.
    J Virol. 1997 Oct;71(10):7478-87 PMID: 9311827
  16. Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia.
    J Virol. 1998 Apr;72(4):3351-61 PMID: 9525662
  17. Virological and molecular demonstration of human immunodeficiency virus type 2 vertical transmission.
    J Virol. 1998 Apr;72(4):3418-22 PMID: 9525673
  18. Productive infection of neonatal CD8+ T lymphocytes by HIV-1.
    J Exp Med. 1998 Apr 6;187(7):1139-44 PMID: 9529330
  19. A broad range of chemokine receptors are used by primary isolates of human immunodeficiency virus type 2 as coreceptors with CD4.
    J Virol. 1998 May;72(5):4065-71 PMID: 9557695
  20. Chemokine receptor utilization by human immunodeficiency virus type 1 isolates that replicate in microglia.
    J Virol. 1998 May;72(5):4243-9 PMID: 9557714
  21. Patterns of CCR5, CXCR4, and CCR3 usage by envelope glycoproteins from human immunodeficiency virus type 1 primary isolates.
    J Virol. 1998 May;72(5):4485-91 PMID: 9557746
  22. Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.
    J Immunol. 1998 Apr 15;160(8):3933-41 PMID: 9558100
  23. Genetically divergent strains of human immunodeficiency virus type 2 use multiple coreceptors for viral entry.
    J Virol. 1998 Jul;72(7):5425-32 PMID: 9620997
  24. Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32.
    J Virol. 1998 Jul;72(7):6040-7 PMID: 9621067
  25. The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1.
    J Virol. 1998 Jul;72(7):6113-8 PMID: 9621075
  26. Role of the thymus in pediatric HIV-1 infection.
    J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):95-109 PMID: 9637574
  27. The ability of HIV type 1 to use CCR-3 as a coreceptor is controlled by envelope V1/V2 sequences acting in conjunction with a CCR-5 tropic V3 loop.
    Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7682-6 PMID: 9636210
  28. Primary SIVsm isolates use the CCR5 coreceptor from sooty mangabeys naturally infected in west Africa: a comparison of coreceptor usage of primary SIVsm, HIV-2, and SIVmac.
    Virology. 1998 Jun 20;246(1):113-24 PMID: 9656999
  29. Genotyping HIV-1 and HCV strains by a combinatorial DNA melting assay (COMA).
    Mol Med. 1998 Jul;4(7):443-53 PMID: 9713823
  30. An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus.
    J Virol. 1998 Oct;72(10):7934-40 PMID: 9733831
  31. Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239.
    J Virol. 1997 Mar;71(3):2522-7 PMID: 9032394
  32. Change in coreceptor use correlates with disease progression in HIV-1--infected individuals.
    J Exp Med. 1997 Feb 17;185(4):621-8 PMID: 9034141
  33. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk.
    Mol Med. 1997 Jan;3(1):23-36 PMID: 9132277
  34. Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry.
    J Virol. 1997 Apr;71(4):2705-14 PMID: 9060623
  35. Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys.
    J Virol. 1997 May;71(5):3953-60 PMID: 9094672
  36. Maternal HIV-1 viral load and vertical transmission of infection: the Ariel Project for the prevention of HIV transmission from mother to infant.
    Nat Med. 1997 May;3(5):549-52 PMID: 9142125
  37. CD4-independent infection by HIV-2 (ROD/B): use of the 7-transmembrane receptors CXCR-4, CCR-3, and V28 for entry.
    Virology. 1997 Apr 28;231(1):130-4 PMID: 9143311
  38. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.
    J Exp Med. 1997 Jun 2;185(11):2015-23 PMID: 9166430
  39. Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry.
    Science. 1997 Jun 20;276(5320):1874-8 PMID: 9188536
  40. A new SIV co-receptor, STRL33.
    Nature. 1997 Jul 17;388(6639):238 PMID: 9230431
  41. Expression cloning of new receptors used by simian and human immunodeficiency viruses.
    Nature. 1997 Jul 17;388(6639):296-300 PMID: 9230441
  42. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection.
    J Exp Med. 1997 Aug 4;186(3):405-11 PMID: 9236192
  43. The amino-terminal domain of the CCR2 chemokine receptor acts as coreceptor for HIV-1 infection.
    J Clin Invest. 1997 Aug 1;100(3):497-502 PMID: 9239395
  44. CC chemokine receptor 5-mediated signaling and HIV-1 Co-receptor activity share common structural determinants. Critical residues in the third extracellular loop support HIV-1 fusion.
    J Biol Chem. 1997 Aug 8;272(32):19771-6 PMID: 9242636
  45. Chemokine receptors and human immunodeficiency virus infection.
    Front Biosci. 1998;3:d44-58 PMID: 9407151
  46. Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex.
    J Virol. 1988 Jun;62(6):2026-32 PMID: 3130494
  47. Host range mutant of human immunodeficiency virus type 1: modification of cell tropism by a single point mutation at the neutralization epitope in the env gene.
    J Virol. 1991 Apr;65(4):1710-8 PMID: 2002539
  48. Transmission of human immunodeficiency virus type 1 (HIV-1) from mother to child correlates with viral phenotype.
    Virology. 1993 Dec;197(2):624-9 PMID: 8249285
  49. Genetic diversity of human immunodeficiency virus type 2: evidence for distinct sequence subtypes with differences in virus biology.
    J Virol. 1994 Nov;68(11):7433-47 PMID: 7933127
  50. Isolation and characterization of a syncytium-inducing, macrophage/T-cell line-tropic human immunodeficiency virus type 1 isolate that readily infects chimpanzee cells in vitro and in vivo.
    J Virol. 1995 Jul;69(7):4453-62 PMID: 7769705
  51. Genetic analysis of human immunodeficiency virus type 1 strains from patients in Cyprus: identification of a new subtype designated subtype I.
    J Virol. 1995 Oct;69(10):6122-30 PMID: 7666516
  52. A computer program designed to screen rapidly for HIV type 1 intersubtype recombinant sequences.
    AIDS Res Hum Retroviruses. 1995 Nov;11(11):1413-6 PMID: 8573400
  53. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time.
    Science. 1996 Mar 15;271(5255):1582-6 PMID: 8599114
  54. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.
    Science. 1996 May 10;272(5263):872-7 PMID: 8629022
  55. Identification of a major co-receptor for primary isolates of HIV-1.
    Nature. 1996 Jun 20;381(6584):661-6 PMID: 8649511
  56. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.
    Nature. 1996 Jun 20;381(6584):667-73 PMID: 8649512
  57. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.
    Cell. 1996 Jun 28;85(7):1135-48 PMID: 8674119
  58. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.
    Cell. 1996 Jun 28;85(7):1149-58 PMID: 8674120
  59. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1.
    Science. 1996 Jun 28;272(5270):1955-8 PMID: 8658171
  60. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.
    Cell. 1996 Aug 9;86(3):367-77 PMID: 8756719
  61. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.
    Nature. 1996 Aug 22;382(6593):722-5 PMID: 8751444
  62. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study.
    Science. 1996 Sep 27;273(5283):1856-62 PMID: 8791590
  63. HIV-1 neutralization: the consequences of viral adaptation to growth on transformed T cells.
    AIDS. 1995;9 Suppl A:S117-36 PMID: 8819579
  64. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.
    Nat Med. 1996 Nov;2(11):1240-3 PMID: 8898752
  65. CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.
    Cell. 1996 Nov 15;87(4):745-56 PMID: 8929542
  66. CD4+ memory T cells are the predominant population of HIV-1-infected lymphocytes in neonates and children.
    AIDS. 1996 Nov;10(13):1477-84 PMID: 8931781
  67. Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry.
    J Virol. 1996 Dec;70(12):8355-60 PMID: 8970955
  68. Sensitivity to inhibition by beta-chemokines correlates with biological phenotypes of primary HIV-1 isolates.
    Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15382-7 PMID: 8986820
  69. Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent.
    J Virol. 1997 Feb;71(2):1692-6 PMID: 8995702
  70. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.
    J Clin Invest. 1997 Jan 15;99(2):178-84 PMID: 9005985
  71. HIV-1 tropism and co-receptor use.
    Nature. 1997 Feb 6;385(6616):495-6 PMID: 9020356
  72. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia.
    Nature. 1997 Feb 13;385(6617):645-9 PMID: 9024664
  73. Determinants of HIV-1 coreceptor function on CC chemokine receptor 3. Importance of both extracellular and transmembrane/cytoplasmic regions.
    J Biol Chem. 1997 Aug 15;272(33):20420-6 PMID: 9252350
  74. Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor.
    J Virol. 1997 Sep;71(9):6296-304 PMID: 9261346
  75. Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entry.
    Virology. 1997 Sep 1;235(2):179-90 PMID: 9281497
  76. Increased losses of CD4+CD45RA+ cells in late stages of HIV infection is related to increased risk of death: evidence from a cohort of 347 HIV-infected individuals.
    AIDS. 1997 Oct;11(12):1479-85 PMID: 9342070
  77. Usage of the coreceptors CCR-5, CCR-3, and CXCR-4 by primary and cell line-adapted human immunodeficiency virus type 2.
    J Virol. 1997 Nov;71(11):8237-44 PMID: 9343175
  78. Promiscuous use of CC and CXC chemokine receptors in cell-to-cell fusion mediated by a human immunodeficiency virus type 2 envelope protein.
    J Virol. 1997 Nov;71(11):8405-15 PMID: 9343197
  79. Inhibition of HIV-1 infection by the beta-chemokine MDC.
    Science. 1997 Oct 24;278(5338):695-8 PMID: 9381181
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.72.11.9337-9344.1998
Published
1998-11-00
Pages
9337-44
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC110357
Subset
IM
Grants
NIAID NIH HHS · R01 AI041420 · United States
NIAID NIH HHS · AI41420 · United States
External Links
PubMed source DOI: 10.1128/JVI.72.11.9337-9344.1998 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2