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PMID: 9557695 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A broad range of chemokine receptors are used by primary isolates of human immunodeficiency virus type 2 as coreceptors with CD4.

Journal of virology ·Vol. 72 ·No. 5 ·1998-05-00 ·Pages 4065-71

McKnight A, Dittmar MT, Moniz-Periera J, Ariyoshi K, Reeves JD, Hibbitts S, Whitby D, Aarons E, Proudfoot AE, Whittle H, Clapham PR

Abstract

Like human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), HIV-2 requires a coreceptor in addition to CD4 for entry into cells. HIV and SIV coreceptor molecules belong to a family of seven-transmembrane-domain G-protein-coupled receptors. Here we show that primary HIV-2 isolates can use a broad range of coreceptor molecules, including CCR1, CCR2b, CCR3, CCR4, CCR5, and CXCR4. Despite broad coreceptor use, the chemokine ligand SDF-1 substantially blocked HIV-2 infectivity of peripheral blood mononuclear cells, indicating that its receptor, CXCR4, was the predominant coreceptor for infection of these cells. However, expression of CXCR4 together with CD4 on some cell types did not confer susceptibility to infection by all CXCR4-using virus isolates. These data therefore indicate that another factor(s) influences the ability of HIV-2 to replicate in human cell types that express the appropriate receptors for virus entry.

MeSH Terms
Adaptation, Biological CD4 Antigens/metabolism Chemokine CCL2/metabolism Chemokine CCL5/analogs & derivatives Chemokine CXCL12 Chemokines, CXC/metabolism Gene Deletion HIV Infections/virology HIV-2/isolation & purification,metabolism Humans Leukocytes, Mononuclear/virology Ligands Phenotype Receptors, CCR5/genetics,metabolism Receptors, Chemokine/metabolism T-Lymphocytes/virology Tumor Cells, Cultured
Chemicals
CD4 Antigens CXCL12 protein, human Chemokine CCL2 Chemokine CCL5 Chemokine CXCL12 Chemokines, CXC Ligands Receptors, CCR5 Receptors, Chemokine
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
McKnight A
Section of Virology, Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom. aine@icr.ac.uk
Dittmar M T
Moniz-Periera J
Ariyoshi K
Reeves J D
Hibbitts S
Whitby D
Aarons E
Proudfoot A E
Whittle H
Clapham P R
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.72.5.4065-4071.1998
Email
aine@icr.ac.uk
Published
1998-05-00
Pages
4065-71
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC109635
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.72.5.4065-4071.1998 PMC Full Text View journal details
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