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PMID: 1673040 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by Simian immunodeficiency virus.

Virology ·Vol. 181 ·No. 2 ·1991-04-00 ·Pages 703-15

Clapham PR, Blanc D, Weiss RA

Abstract

Human CD4 was expressed on a range of mammalian cell lines. CD4+ non-primate cells, derived from rat, hamster, mink, cat, and rabbit, bind recombinant gp120 of human immunodeficiency virus type 1 (HIV-1) but are resistant to HIV-1 infection. CD4 expression on various human, rhesus, and African green monkey cell lines confers differential susceptibilities for HIV-1, HIV-2, and simian immunodeficiency (SIV) strains. For example, CD4+ TE671 rhabdomyosarcoma cells are sensitive to HIV-1 and HIV-2 but resistant to SIV, whereas CD4+ U87 glioma cells are resistant to HIV-1 infection but sensitive to HIV-2 and SIV. HIV-1 infection was not dependent on human major histocompatibility class I expression. Studies of cell fusion and of infection by vesicular stomatitis virus pseudotypes bearing HIV-1 and HIV-2 envelopes showed that the differential cell tropisms of HIV-1, HIV-2, and SIV are determined at the cell surface.

MeSH Terms
Acquired Immunodeficiency Syndrome/immunology,pathology Animals Base Sequence CD4-Positive T-Lymphocytes/immunology,microbiology Cell Line Cytopathogenic Effect, Viral Disease Susceptibility HIV Envelope Protein gp120/immunology HIV-1/physiology HIV-2/physiology Humans Membrane Fusion Molecular Sequence Data Simian Acquired Immunodeficiency Syndrome/immunology,pathology Simian Immunodeficiency Virus/growth & development,physiology
Chemicals
HIV Envelope Protein gp120
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Clapham P R
Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.
Blanc D
Weiss R A
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Article Info
Journal
Virology
Abbr.
Virology
ISSN
0042-6822
DOI
10.1016/0042-6822(91)90904-p
Published
1991-04-00
Pages
703-15
Language
English
Region
United States
NLM ID
0110674
PMCID
PMC7131431
Subset
IM
External Links
PubMed source DOI: 10.1016/0042-6822(91)90904-p PMC Full Text View journal details
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