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PMID: 9548711 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights.

The Journal of cell biology ·Vol. 141 ·No. 2 ·1998-04-20 ·Pages 309-19

Hudson DF, Fowler KJ, Earle E, Saffery R, Kalitsis P, Trowell H, Hill J, Wreford NG, de Kretser DM, Cancilla MR, Howman E, Hii L, Cutts SM, Irvine DV, Choo KH

Abstract

CENP-B is a constitutive centromere DNA-binding protein that is conserved in a number of mammalian species and in yeast. Despite this conservation, earlier cytological and indirect experimental studies have provided conflicting evidence concerning the role of this protein in mitosis. The requirement of this protein in meiosis has also not previously been described. To resolve these uncertainties, we used targeted disruption of the Cenpb gene in mouse to study the functional significance of this protein in mitosis and meiosis. Male and female Cenpb null mice have normal body weights at birth and at weaning, but these subsequently lag behind those of the heterozygous and wild-type animals. The weight and sperm content of the testes of Cenpb null mice are also significantly decreased. Otherwise, the animals appear developmentally and reproductively normal. Cytogenetic fluorescence-activated cell sorting and histological analyses of somatic and germline tissues revealed no abnormality. These results indicate that Cenpb is not essential for mitosis or meiosis, although the observed weight reduction raises the possibility that Cenpb deficiency may subtly affect some aspects of centromere assembly and function, and result in reduced rate of cell cycle progression, efficiency of microtubule capture, and/or chromosome movement. A model for a functional redundancy of this protein is presented.

MeSH Terms
Animals Autoantigens Body Weight/genetics Centromere/chemistry Centromere Protein B Chromosomal Proteins, Non-Histone/analysis,genetics,physiology DNA-Binding Proteins Female Karyotyping Male Meiosis/physiology Mice Mice, Knockout Mitosis/physiology Organ Size Sperm Count Testis/growth & development
Chemicals
Autoantigens Cenpb protein, mouse Centromere Protein B Chromosomal Proteins, Non-Histone DNA-Binding Proteins
Authors & Affiliations
15 authors, click to expand affiliations / ORCID
Hudson D F
The Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Parkville 3052, Australia.
Fowler K J
Earle E
Saffery R
Kalitsis P
Trowell H
Hill J
Wreford N G
de Kretser D M
Cancilla M R
Howman E
Hii L
Cutts S M
Irvine D V
Choo K H
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
Published
1998-04-20
Pages
309-19
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2148459
Subset
IM
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