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PMID: 9294784 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Molecular pharmacology of somatostatin receptor subtypes.

Journal of endocrinological investigation ·Vol. 20 ·No. 6 ·1997-06-00 ·Pages 348-67

Patel YC

Abstract

暂无摘要

MeSH Terms
Amino Acid Sequence Animals Binding Sites GTP-Binding Proteins/physiology Gene Expression Regulation Humans Molecular Sequence Data Neoplasms/metabolism Receptors, Somatostatin/chemistry,drug effects,genetics,metabolism,physiology Signal Transduction
Chemicals
Receptors, Somatostatin GTP-Binding Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Patel Y C
Fraser Laboratories, McGill University, Department of Medicine, Montreal, Quebec, Canada.
References (153)
153 references, click to expand
  1. Differential expression of somatostatin receptor subtypes in brain.
    J Neurosci. 1992 Oct;12(10):3920-34 PMID: 1403090
  2. 17-beta-estradiol-dependent regulation of somatostatin receptor subtype expression in the 7315b prolactin secreting rat pituitary tumor in vitro and in vivo.
    Endocrinology. 1997 Mar;138(3):1180-9 PMID: 9048625
  3. Internalization of the radioiodinated somatostatin analog [125I-Tyr3]octreotide by mouse and human pituitary tumor cells: increase by unlabeled octreotide.
    Endocrinology. 1995 Sep;136(9):3698-706 PMID: 7649075
  4. G protein specificity in receptor-effector coupling. Analysis of the roles of G0 and Gi2 in GH4C1 pituitary cells.
    J Biol Chem. 1994 May 13;269(19):13880-6 PMID: 8188665
  5. Somatostatin receptor subtype SSTR2 mediates the inhibition of high-voltage-activated calcium channels by somatostatin and its analogue SMS 201-995.
    FEBS Lett. 1994 Nov 28;355(2):117-20 PMID: 7982482
  6. Development of a selective agonist at the somatostatin receptor subtype sstr1.
    J Pharmacol Exp Ther. 1996 Mar;276(3):1089-94 PMID: 8786539
  7. Expression of five somatostatin receptor mRNAs in the human brain and pituitary.
    Naunyn Schmiedebergs Arch Pharmacol. 1996 Oct;354(4):411-9 PMID: 8897442
  8. Molecular biology of somatostatin receptor subtypes.
    Metabolism. 1996 Aug;45(8 Suppl 1):31-8 PMID: 8769376
  9. Up-regulation of somatostatin receptors by epidermal growth factor and gastrin in pancreatic cancer cells.
    Mol Pharmacol. 1994 Jul;46(1):97-104 PMID: 8058063
  10. Characterization of the cyclic AMP-independent actions of somatostatin in GH cells. II. An increase in potassium conductance initiates somatostatin-induced inhibition of prolactin secretion.
    J Biol Chem. 1988 Jan 5;263(1):226-34 PMID: 2891696
  11. Subtype-specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2.
    J Biol Chem. 1994 Apr 8;269(14):10357-62 PMID: 8144617
  12. Somatostatin regulates somatostatin receptor subtype mRNA expression in GH3 cells.
    Biochem Biophys Res Commun. 1994 Aug 15;202(3):1738-43 PMID: 7914724
  13. Inhibition of human breast cancer cell (MCF-7) growth in vitro by the somatostatin analog SMS 201-995: effects on cell cycle parameters and apoptotic cell death.
    Endocrinology. 1991 Nov;129(5):2555-62 PMID: 1935786
  14. Differential internalization of somatostatin in COS-7 cells transfected with SST1 and SST2 receptor subtypes: a confocal microscopic study using novel fluorescent somatostatin derivatives.
    Endocrinology. 1997 Jan;138(1):296-306 PMID: 8977417
  15. Characterization of the proximal promoter region of the rat somatostatin receptor gene, SSTR4.
    Biochem Biophys Res Commun. 1995 Jan 26;206(3):935-41 PMID: 7832807
  16. Arachidonic acid metabolites as mediators of somatostatin-induced increase of neuronal M-current.
    Nature. 1990 Aug 2;346(6283):464-7 PMID: 1974033
  17. Mechanism of action of somatostatin: an overview of receptor function and studies of the molecular characterization and purification of somatostatin receptor proteins.
    Metabolism. 1990 Sep;39(9 Suppl 2):63-9 PMID: 1976223
  18. N-terminally extended somatostatin: the primary structure of somatostatin-28.
    FEBS Lett. 1980 Jan 1;109(1):55-8 PMID: 7353633
  19. Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents.
    Nature. 1991 Sep 5;353(6339):43-8 PMID: 1679199
  20. Distribution of somatostatin receptors in RINm5F insulinoma cells.
    Endocrinology. 1988 Mar;122(3):1137-45 PMID: 2893729
  21. Expression of three somatostatin receptor subtypes in pituitary adenomas: evidence for preferential SSTR5 expression in the mammosomatotroph lineage.
    J Clin Endocrinol Metab. 1994 Sep;79(3):724-9 PMID: 7521350
  22. Expression cloning of a rat brain somatostatin receptor cDNA.
    Proc Natl Acad Sci U S A. 1992 May 15;89(10):4618-22 PMID: 1374909
  23. Octreotide.
    N Engl J Med. 1996 Jan 25;334(4):246-54 PMID: 8532003
  24. Thyroid hormone-induced expression of specific somatostatin receptor subtypes correlates with involution of the TtT-97 murine thyrotrope tumor.
    Endocrinology. 1997 Feb;138(2):719-24 PMID: 9003007
  25. Identification of a critical aspartate residue in transmembrane domain three necessary for the binding of somatostatin to the somatostatin receptor SSTR2.
    Biochem Biophys Res Commun. 1995 Nov 22;216(3):913-21 PMID: 7488212
  26. Characterization of a human gene related to genes encoding somatostatin receptors.
    FEBS Lett. 1996 Dec 2;398(2-3):253-8 PMID: 8977118
  27. Somatostatin-induced inhibition of neuronal Ca2+ current modulated by cGMP-dependent protein kinase.
    Nature. 1994 May 26;369(6478):336-9 PMID: 7910377
  28. 6agonist selectivity determinants in somatostatin receptor subtypes I and II.
    J Biol Chem. 1994 Oct 7;269(40):24621-6 PMID: 7929134
  29. Molecular pharmacology of somatostatin receptors.
    Fundam Clin Pharmacol. 1995;9(2):107-13 PMID: 7628822
  30. Cloning of a delta opioid receptor by functional expression.
    Science. 1992 Dec 18;258(5090):1952-5 PMID: 1335167
  31. SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action.
    Life Sci. 1982 Sep 13;31(11):1133-40 PMID: 6128648
  32. Modulation of high voltage-activated calcium channels by somatostatin in acutely isolated rat amygdaloid neurons.
    J Neurosci. 1996 Oct 1;16(19):6000-11 PMID: 8815883
  33. Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.
    Mol Pharmacol. 1993 Jun;43(6):838-44 PMID: 8100350
  34. Characterization of functional receptors for somatostatin in rat pituitary cells in culture.
    J Biol Chem. 1978 Sep 25;253(18):6473-83 PMID: 210185
  35. Beta-adrenergic and somatostatin receptors regulate Na-H exchange independent of cAMP.
    J Biol Chem. 1989 Dec 15;264(35):21038-42 PMID: 2574175
  36. Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP.
    Proc Natl Acad Sci U S A. 1989 Apr;86(8):2971-5 PMID: 2565041
  37. Heterogeneous expression of two somatostatin receptor subtypes in pituitary tumors.
    J Clin Endocrinol Metab. 1994 Feb;78(2):398-403 PMID: 8106629
  38. Somatostatin activates an inwardly rectifying K+ conductance in freshly dispersed rat somatotrophs.
    J Physiol. 1991 Sep;441:615-37 PMID: 1687749
  39. Structure and function of receptors coupled to G proteins.
    Curr Opin Cell Biol. 1994 Apr;6(2):180-90 PMID: 8024808
  40. The family of G-protein-coupled receptors.
    FASEB J. 1995 Jun;9(9):745-54 PMID: 7601339
  41. Identification and quantification of Gi-type GTP-binding proteins that copurify with a pituitary somatostatin receptor.
    J Biol Chem. 1993 Mar 15;268(8):5990-6 PMID: 8449959
  42. Co-purification of a protein tyrosine phosphatase with activated somatostatin receptors from rat pancreatic acinar membranes.
    Biochem J. 1994 Oct 15;303 ( Pt 2):441-8 PMID: 7980402
  43. Cyclic AMP regulates somatostatin mRNA accumulation in primary diencephalic cultures and in transfected fibroblast cells.
    J Neurosci. 1986 Apr;6(4):1171-6 PMID: 2871140
  44. Cloning and expression of a rat somatostatin receptor enriched in brain.
    J Biol Chem. 1992 Oct 25;267(30):21307-12 PMID: 1400442
  45. Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.
    Mol Pharmacol. 1993 Jun;43(6):894-901 PMID: 8100352
  46. Reconstitution of somatostatin and muscarinic receptor mediated stimulation of K+ channels by isolated GK protein in clonal rat anterior pituitary cell membranes.
    Mol Endocrinol. 1987 Apr;1(4):283-9 PMID: 2456451
  47. Glutamate 301 of the mouse gonadotropin-releasing hormone receptor confers specificity for arginine 8 of mammalian gonadotropin-releasing hormone.
    J Biol Chem. 1994 Sep 9;269(36):22636-41 PMID: 7915716
  48. Cell cycle dependent induction of apoptosis by somatostatin analog SMS 201-995 in AtT-20 mouse pituitary cells.
    Biochem Biophys Res Commun. 1995 Apr 17;209(2):400-6 PMID: 7733906
  49. Purification of a pituitary receptor for somatostatin. The utility of biotinylated somatostatin analogs.
    J Biol Chem. 1992 Aug 5;267(22):15603-12 PMID: 1353497
  50. Gi alpha 1 selectively couples somatostatin receptors to adenylyl cyclase in pituitary-derived AtT-20 cells.
    Mol Pharmacol. 1992 Mar;41(3):452-5 PMID: 1347639
  51. The neurobiology of somatostatin.
    Crit Rev Neurobiol. 1994;8(1-2):25-44 PMID: 7907281
  52. Somatostatin stimulates Ca(2+)-activated K+ channels through protein dephosphorylation.
    Nature. 1991 Jun 13;351(6327):570-3 PMID: 1710783
  53. Somatostatin-14 and somatostatin-28 induce opposite effects on potassium currents in rat neocortical neurons.
    Proc Natl Acad Sci U S A. 1989 Dec;86(23):9616-20 PMID: 2574465
  54. Effect of calcium on the secretion of somatostatin and insulin from pancreatic islets.
    Endocrinology. 1981 Jun;108(6):2254-7 PMID: 6112135
  55. 17 beta-estradiol induces somatostatin (SRIF) inhibition of prolactin release and regulates SRIF receptors in rat anterior pituitary cells.
    Endocrinology. 1986 Sep;119(3):1028-36 PMID: 2874016
  56. Cloning and characterization of a fourth human somatostatin receptor.
    Proc Natl Acad Sci U S A. 1993 May 1;90(9):4196-200 PMID: 8483934
  57. Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype.
    J Biol Chem. 1994 Jan 14;269(2):1506-9 PMID: 7904601
  58. Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells.
    J Clin Invest. 1989 Aug;84(2):412-7 PMID: 2569474
  59. Binding properties of somatostatin receptor subtypes.
    Metabolism. 1996 Aug;45(8 Suppl 1):17-20 PMID: 8769372
  60. Embryonic and postnatal mRNA distribution of five somatostatin receptor subtypes in the rat brain.
    Neuropharmacology. 1995 Dec;34(12):1673-88 PMID: 8788965
  61. Evidence that somatostatin is localized and synthesized in lymphoid organs.
    Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11485-9 PMID: 1684864
  62. The D2 dopamine receptor isoforms signal through distinct Gi alpha proteins to inhibit adenylyl cyclase. A study with site-directed mutant Gi alpha proteins.
    J Biol Chem. 1994 Sep 16;269(37):23120-7 PMID: 7916015
  63. Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.
    Mol Endocrinol. 1992 Dec;6(12):2136-42 PMID: 1337145
  64. Molecular pharmacology of somatostatin receptors.
    Naunyn Schmiedebergs Arch Pharmacol. 1994 Nov;350(5):441-53 PMID: 7870182
  65. Purification of a putative brain somatostatin receptor.
    Proc Natl Acad Sci U S A. 1989 Mar;86(5):1480-4 PMID: 2564203
  66. Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors.
    J Clin Invest. 1994 Mar;93(3):1321-5 PMID: 8132773
  67. Cloning and expression of a novel mouse somatostatin receptor (SSTR2B).
    FEBS Lett. 1992 Oct 26;311(3):290-4 PMID: 1397330
  68. Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells.
    Endocrinology. 1996 Aug;137(8):3461-8 PMID: 8754775
  69. The somatostatin receptor family.
    Life Sci. 1995;57(13):1249-65 PMID: 7674817
  70. Somatostatinoma syndrome. Biochemical, morphologic and clinical features.
    N Engl J Med. 1979 Aug 9;301(6):285-92 PMID: 377080
  71. Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain.
    Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10267-71 PMID: 1279674
  72. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms.
    Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1580-4 PMID: 7878022
  73. Photoaffinity labeling of the somatostatin receptor: identification of molecular subtypes.
    Endocrinology. 1992 May;130(5):2937-46 PMID: 1349280
  74. G protein activation of a hormone-stimulated phosphatase in human tumor cells.
    Science. 1992 May 22;256(5060):1215-7 PMID: 1350382
  75. Widespread distribution of somatostatin receptor messenger ribonucleic acids in rat pituitary.
    Endocrinology. 1995 Nov;136(11):5224-7 PMID: 7588261
  76. Somatostatin blocks a calcium current in rat sympathetic ganglion neurones.
    J Physiol. 1989 Feb;409:221-40 PMID: 2479736
  77. Aspartic acid residue 124 in the third transmembrane domain of the somatostatin receptor subtype 3 is essential for somatostatin-14 binding.
    DNA Cell Biol. 1995 Nov;14(11):939-44 PMID: 7576180
  78. The role of somatostatin and its analogs in the diagnosis and treatment of tumors.
    Endocr Rev. 1991 Nov;12(4):450-82 PMID: 1684746
  79. Somatostatin action in pituitary cells involves two independent transduction mechanism.
    Metabolism. 1990 Sep;39(9 Suppl 2):96-100 PMID: 1976226
  80. Prolonged somatostatin pretreatment desensitizes somatostatin's inhibition of receptor-mediated release of adrenocorticotropin hormone and sensitizes adenylate cyclase.
    Endocrinology. 1983 Aug;113(2):811-3 PMID: 6135600
  81. Endocytosis of the rat somatostatin receptors: subtype discrimination, ligand specificity, and delineation of carboxy-terminal positive and negative sequence motifs.
    DNA Cell Biol. 1997 Jan;16(1):111-9 PMID: 9022050
  82. A super active cyclic hexapeptide analog of somatostatin.
    Life Sci. 1984 Apr 2;34(14):1371-8 PMID: 6143233
  83. Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase.
    Proc Natl Acad Sci U S A. 1989 Mar;86(6):2003-7 PMID: 2564678
  84. Is there a 'lock' for all agonist 'keys' in 7TM receptors?
    Trends Pharmacol Sci. 1996 Jun;17(6):213-6 PMID: 8763197
  85. Somatostatin.
    N Engl J Med. 1983 Dec 15;309(24):1495-501 PMID: 6139753
  86. Agonist-dependent regulation of cloned human somatostatin receptor types 1-5 (hSSTR1-5): subtype selective internalization or upregulation.
    Endocrinology. 1996 Sep;137(9):4046-9 PMID: 8756582
  87. Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.
    Biochem J. 1996 Mar 1;314 ( Pt 2):401-4 PMID: 8670047
  88. Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat.
    Endocrinology. 1994 Nov;135(5):1787-92 PMID: 7956902
  89. Evidence that receptor-linked G protein inhibits exocytosis by a post-second-messenger mechanism in AtT-20 cells.
    J Neurochem. 1990 Jan;54(1):30-8 PMID: 1967144
  90. Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin.
    Neuron. 1996 Sep;17(3):513-22 PMID: 8816714
  91. Somatostatin receptors: identification and characterization in rat brain membranes.
    Proc Natl Acad Sci U S A. 1981 Jun;78(6):3930-4 PMID: 6115385
  92. Ligand binding pocket of the human somatostatin receptor 5: mutational analysis of the extracellular domains.
    Mol Pharmacol. 1997 Nov;52(5):807-14 PMID: 9351971
  93. Somatostatin inhibits PC Cl3 thyroid cell proliferation through the modulation of phosphotyrosine activity. Impairment of the somatostatinergic effects by stable expression of E1A viral oncogene.
    J Biol Chem. 1996 Mar 15;271(11):6129-36 PMID: 8626400
  94. Somatostatin inhibition of hormone release: effects on cytosolic Ca++ and interference with distal secretory events.
    Metabolism. 1990 Sep;39(9 Suppl 2):101-4 PMID: 1976201
  95. Identification of somatostatin receptors by covalent labeling with a novel photoreactive somatostatin analog.
    J Biol Chem. 1990 Oct 15;265(29):17995-8004 PMID: 1976633
  96. The tuberin (TSC2), autosomal dominant polycystic kidney disease (PKD1), and somatostatin type V receptor (SSTR5) genes form a synteny group in the Fugu genome.
    Genomics. 1996 Nov 15;38(1):84-6 PMID: 8954784
  97. The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells.
    Mol Endocrinol. 1994 Oct;8(10):1289-97 PMID: 7854346
  98. Selective binding of somatostatin-14 and somatostatin-28 to islet cells revealed by quantitative electron microscopic autoradiography.
    J Clin Invest. 1987 Nov;80(5):1455-8 PMID: 2890658
  99. Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.
    Biochem Biophys Res Commun. 1993 Apr 15;192(1):288-94 PMID: 8386508
  100. Solubilization and partial purification of somatostatin-28 preferring receptors from hamster pancreatic beta cells.
    J Biol Chem. 1992 Aug 5;267(22):15620-5 PMID: 1353498
  101. Loss of the polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss-of-function model for cyst pathogenesis.
    J Clin Invest. 1997 Jan 15;99(2):194-9 PMID: 9005987
  102. Phospholipase C activation and Ca2+ mobilization by cloned human somatostatin receptor subtypes 1-5, in transfected COS-7 cells.
    FEBS Lett. 1994 Jul 11;348(2):192-6 PMID: 8034040
  103. Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).
    Endocrinology. 1994 Dec;135(6):2814-7 PMID: 7988476
  104. Identification and characterization of novel somatostatin antagonists.
    Mol Pharmacol. 1996 Oct;50(4):709-15 PMID: 8863814
  105. Sequence analysis of the promoter region of the rat somatostatin receptor subtype 1 gene.
    FEBS Lett. 1994 May 30;345(2-3):225-8 PMID: 8060391
  106. Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1.
    Biochem Biophys Res Commun. 1997 Jan 3;230(1):69-72 PMID: 9020062
  107. Distinct subsets of somatostatin receptors on cultured human lymphocytes.
    J Biol Chem. 1989 Jan 15;264(2):949-52 PMID: 2562957
  108. Molecular cloning and functional expression of a brain-specific somatostatin receptor.
    Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11151-5 PMID: 1360663
  109. Receptor binding of somatostatin-28 is tissue specific.
    Nature. 1981 Nov 19;294(5838):259-60 PMID: 6117799
  110. Regulation of islet somatostatin secretion and gene expression: selective effects of adenosine 3',5'-monophosphate and phorbol esters in normal islets of Langerhans and in a somatostatin-producing rat islet clonal cell line 1027 B2.
    Endocrinology. 1991 Apr;128(4):1754-62 PMID: 1672273
  111. Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28.
    Mol Pharmacol. 1994 Mar;45(3):417-27 PMID: 7908405
  112. Molecular and pharmacological characterization of somatostatin receptor subtypes in adrenal, extraadrenal, and malignant pheochromocytomas.
    J Clin Endocrinol Metab. 1995 Jun;80(6):1837-44 PMID: 7775631
  113. An early increase in somatostatin mRNA expression in the frontal cortex of rhesus monkeys infected with simian immunodeficiency virus.
    Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1371-5 PMID: 7877985
  114. Somatostatin receptor subtype gene expression in pituitary adenomas.
    J Clin Endocrinol Metab. 1995 Apr;80(4):1386-92 PMID: 7714115
  115. Localization of the somatostatin receptor SST2A in rat brain using a specific anti-peptide antibody.
    J Neurosci. 1996 Jul 15;16(14):4468-78 PMID: 8699257
  116. Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae.
    Life Sci. 1996;58(13):1091-8 PMID: 8622562
  117. Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.
    J Biol Chem. 1992 Oct 5;267(28):20422-8 PMID: 1328199
  118. Growth hormone-releasing factor increases somatostatin release and mRNA levels in the rat periventricular nucleus via nitric oxide by activation of guanylate cyclase.
    Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):782-6 PMID: 7904758
  119. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.
    Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):251-5 PMID: 1346068
  120. Somatostatin receptor subtypes in the clonal anterior pituitary cell lines AtT-20 and GH3.
    Mol Pharmacol. 1988 Apr;33(4):370-7 PMID: 2895889
  121. Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells. A double labeling in situ hybridization analysis.
    Endocrinology. 1995 Nov;136(11):5232-5 PMID: 7588263
  122. Molecular biology of somatostatin receptors.
    Endocr Rev. 1995 Aug;16(4):427-42 PMID: 8521788
  123. Two amino acids, located in transmembrane domains VI and VII, determine the selectivity of the peptide agonist SMS 201-995 for the SSTR2 somatostatin receptor.
    EMBO J. 1995 Feb 15;14(4):727-35 PMID: 7882976
  124. Dexamethasone regulates somatostatin receptor subtype messenger ribonucleic acid expression in rat pituitary GH4C1 cells.
    Endocrinology. 1995 Nov;136(11):5070-5 PMID: 7588243
  125. Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade.
    J Biol Chem. 1994 Apr 29;269(17):12722-30 PMID: 8175684
  126. In vitro and in vivo inhibition of human small cell lung carcinoma (NCI-H69) growth by a somatostatin analogue.
    Biochem Biophys Res Commun. 1988 May 31;153(1):81-6 PMID: 2897854
  127. Expression of somatostatin receptor subtypes in cultured astrocytes and gliomas.
    J Neurochem. 1995 Nov;65(5):1997-2005 PMID: 7595483
  128. Expression of somatostatin receptor subtypes in breast carcinoma, carcinoid tumor, and renal cell carcinoma.
    J Clin Endocrinol Metab. 1995 Oct;80(10):2974-9 PMID: 7559883
  129. The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene.
    EMBO J. 1996 Dec 2;15(23):6680-90 PMID: 8978694
  130. Differential expression of messenger RNAs for somatostatin receptor subtypes SSTR1, SSTR2 and SSTR3 in adult rat brain: analysis by RNA blotting and in situ hybridization histochemistry.
    Neuroscience. 1994 Mar;59(1):175-84 PMID: 8190266
  131. Peptides derived from cleavage of prosomatostatin at carboxyl- and amino-terminal segments. Characterization of tissue and secreted forms in the rat.
    J Biol Chem. 1988 Jan 15;263(2):745-51 PMID: 2891703
  132. Sequence analysis of the 5'-flanking promoter region of the human somatostatin receptor 5.
    Biochem Biophys Res Commun. 1994 Dec 30;205(3):1883-90 PMID: 7811278
  133. Tissue distribution of somatostatin receptor subtype messenger ribonucleic acid in the rat.
    Endocrinology. 1993 Dec;133(6):2561-7 PMID: 8243278
  134. Expression of mRNA for all five human somatostatin receptors (hSSTR1-5) in pituitary tumors.
    Life Sci. 1995;56(5):333-42 PMID: 7530798
  135. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.
    Science. 1973 Jan 5;179(4068):77-9 PMID: 4682131
  136. A cortical neuropeptide with neuronal depressant and sleep-modulating properties.
    Nature. 1996 May 16;381(6579):242-5 PMID: 8622767
  137. Affinity purification of a somatostatin receptor-G-protein complex demonstrates specificity in receptor-G-protein coupling.
    J Biol Chem. 1993 Mar 25;268(9):6668-76 PMID: 8454639
  138. Identification of peptide binding residues in the extracellular domains of the AT1 receptor.
    J Biol Chem. 1994 Dec 9;269(49):30953-9 PMID: 7983030
  139. A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.
    FEBS Lett. 1993 Apr 26;321(2-3):279-84 PMID: 8097479
  140. Identification and characterization of a novel human cortistatin-like peptide.
    Biochem Biophys Res Commun. 1997 Mar 6;232(1):157-63 PMID: 9125122
  141. Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3.
    Mol Endocrinol. 1996 Dec;10(12):1688-96 PMID: 8961277
  142. Binding epitopes for peptide and non-peptide ligands on the NK1 (substance P) receptor.
    Regul Pept. 1993 Jul 2;46(1-2):49-58 PMID: 7692567
  143. Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation.
    J Clin Invest. 1997 Feb 15;99(4):789-98 PMID: 9045884
  144. Gi alpha 3 and G(o) alpha selectively associate with the cloned somatostatin receptor subtype SSTR2.
    J Biol Chem. 1993 May 25;268(15):10721-7 PMID: 8098703
  145. Estrogen regulates somatostatin receptor subtype 2 messenger ribonucleic acid expression in human breast cancer cells.
    Endocrinology. 1996 Dec;137(12):5634-40 PMID: 8940394
  146. Cloning of the gene encoding human somatostatin receptor 2: sequence analysis of the 5'-flanking promoter region.
    Gene. 1995 Jul 4;159(2):291-2 PMID: 7622071
  147. All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase.
    Biochem Biophys Res Commun. 1994 Jan 28;198(2):605-12 PMID: 7905265
  148. Distribution of somatostatin receptors in the human brain: an autoradiographic study.
    Neuroscience. 1986 Jun;18(2):329-46 PMID: 2874525
  149. Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28.
    Mol Pharmacol. 1992 Dec;42(6):939-46 PMID: 1362243
  150. Ultrastructural autoradiographic localization of somatostatin-28 in the rat pituitary gland.
    Endocrinology. 1985 Apr;116(4):1615-20 PMID: 2857643
  151. Somatostatin pretreatment increases the number of somatostatin receptors in GH4C1 pituitary cells and does not reduce cellular responsiveness to somatostatin.
    J Biol Chem. 1988 Jan 15;263(2):714-21 PMID: 2891702
  152. 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.
    Nature. 1994 Mar 3;368(6466):32-8 PMID: 7906398
  153. Coexistence of somatostatin receptor subtypes in the human neuroblastoma cell line LA-N-2.
    FEBS Lett. 1997 Jan 13;401(1):83-8 PMID: 9003811
Article Info
Journal
Journal of endocrinological investigation
Abbr.
J Endocrinol Invest
ISSN
0391-4097
Published
1997-06-00
Pages
348-67
Language
English
Region
Italy
NLM ID
7806594
Subset
IM
Grants
NINDS NIH HHS · NS 32160 · United States
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