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PMID: 8710487 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Common DNA structural features exhibited by eukaryotic ribosomal gene promoters.

Nucleic acids research ·Vol. 24 ·No. 12 ·1996-06-15 ·Pages 2204-11

Marilley M, Pasero P

Abstract

Nucleotide sequences of DNA regions containing eukaryotic ribosomal promoters were analysed using strategies designed to reveal sequence-directed structural features. DNA curvature, duplex stability and pattern of twist angle variation were studied by computer modelling. Although ribosomal promoters are known to lack sequence homology (unless very closely related species are considered), investigation of these structural characteristics uncovered striking homologies in all the taxonomic groups examined so far. This wide conservation of DNA structures, while DNA sequence is not conserved, suggests that the determined structures are fundamental for ribosomal promoter function. Moreover, this result agrees well with the recent observations showing that RNA polymerase I transcription factors have not evolved as intensively as previously suspected.

MeSH Terms
Animals Base Sequence DNA, Ribosomal/chemistry Eukaryotic Cells Humans Molecular Sequence Data Nucleic Acid Conformation Promoter Regions, Genetic Sequence Homology, Nucleic Acid Transcription, Genetic
Chemicals
DNA, Ribosomal
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Marilley M
Laboratoire de Génétique GDR CNRS 976, Faculté de Médicine, Marseille, France.
Pasero P
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/24.12.2204
Published
1996-06-15
Pages
2204-11
Language
English
Region
England
NLM ID
0411011
PMCID
PMC145945
Subset
IM
Databases
GENBANK
J01005, J01212, K01588, M10096, M12030, X00184, X00601, X00677, X01547, X02210, X03990, X05263, X07841, X15550, X52575, X63234, Y00132
External Links
PubMed source DOI: 10.1093/nar/24.12.2204 PMC Full Text View journal details
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