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PMID: 8709250 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Multivariate analysis of human immunodeficiency virus type 1 neutralization data.

Journal of virology ·Vol. 70 ·No. 9 ·1996-09-00 ·Pages 6235-43

Nyambi PN, Nkengasong J, Lewi P, Andries K, Janssens W, Fransen K, Heyndrickx L, Piot P, van der Groen G

Abstract

We report on the use of spectral map analysis of the inter- and intraclade neutralization data of 14 sera of human immunodeficiency virus type 1 (HIV-1)-infected individuals and 16 primary isolates, representing genetic clades A to H in group M and group O. This multivariate analysis has been used previously to study the interaction between drugs and receptors and between viruses and antiviral compounds. The analysis reveals the existence of neutralization clusters, not correlated with the known genetic clades. The structural factors that have been identified may correlate with the most important neutralization epitopes. Three key primary HIV-1 isolates, which allow discrimination of sera that are likely or unlikely to neutralize primary isolates from most of the genetic clades, were identified. Our method of analysis will facilitate the evaluation as well as the design of suitable HIV-1 vaccines, which induce high-titer interclade cross-neutralizing antibodies.

MeSH Terms
Acquired Immunodeficiency Syndrome/blood,immunology Algorithms Antibody Specificity HIV Antibodies/blood HIV Infections/blood,immunology HIV-1/classification,genetics,immunology HIV-2/immunology Humans Multivariate Analysis Neutralization Tests Simian Immunodeficiency Virus/immunology
Chemicals
HIV Antibodies
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Nyambi P N
Institute of Tropical Medicine, Antwerp, Belgium.
Nkengasong J
Lewi P
Andries K
Janssens W
Fransen K
Heyndrickx L
Piot P
van der Groen G
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.70.9.6235-6243.1996
Published
1996-09-00
Pages
6235-43
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC190648
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.70.9.6235-6243.1996 PMC Full Text View journal details
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