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PMID: 8665473 Published · ppublish English Journal Article Review

Molecular biology and pathogenesis of animal lentivirus infections.

Clinical microbiology reviews ·Vol. 9 ·No. 1 ·1996-01-00 ·Pages 100-17

Clements JE, Zink MC

Abstract

Lentiviruses are a subfamily of retroviruses that are characterized by long incubation periods between infection of the host and the manifestation of clinical disease. Human immunodeficiency virus type 1, the causative agent of AIDS, is the most widely studied lentivirus. However, the lentiviruses that infect sheep, goats, and horses were identified and studied prior to the emergence of human immunodeficiency virus type 1. These and other animal lentiviruses provide important systems in which to investigate the molecular pathogenesis of this family of viruses. This review will focus on two animal lentivirus models: the ovine lentivirus visna virus; and the simian lentivirus, simian immunodeficiency virus. These animal lentiviruses have been used to examine, in particular, the pathogenesis of lentivirus-induced central nervous system disease as models for humans with AIDS as well as other chronic diseases.

MeSH Terms
Animals Gene Expression Regulation, Viral Genome, Viral Lentivirus/genetics,pathogenicity,physiology Lentivirus Infections/virology Lentiviruses, Ovine-Caprine/pathogenicity Simian Immunodeficiency Virus/genetics,pathogenicity,physiology Tropism
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Clements J E
Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Zink M C
References (214)
214 references, click to expand
  1. Infectious leukoencephalomyelitis of young goats.
    J Infect Dis. 1974 Feb;129(2):134-41 PMID: 4810939
  2. Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus.
    Cell. 1985 Aug;42(1):369-82 PMID: 2410140
  3. Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.
    Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6580-4 PMID: 1631159
  4. Human dUTP pyrophosphatase: cDNA sequence and potential biological importance of the enzyme.
    Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8020-4 PMID: 1325640
  5. Wild-type equine infectious anemia virus replicates in vivo predominantly in tissue macrophages, not in peripheral blood monocytes.
    J Virol. 1992 Oct;66(10):5906-13 PMID: 1382143
  6. Involvement of FOS and JUN in the activation of visna virus gene expression in macrophages through an AP-1 site in the viral LTR.
    Virology. 1992 Sep;190(1):84-91 PMID: 1326822
  7. The role of monocyte/macrophages and cytokines in the pathogenesis of HIV infection.
    Pathobiology. 1992;60(4):246-51 PMID: 1388722
  8. Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes.
    J Virol. 1992 Nov;66(11):6489-95 PMID: 1357189
  9. Cellular tropism and localization in the rodent nervous system of a neuropathogenic variant of Friend murine leukemia virus.
    Lab Invest. 1992 Sep;67(3):314-21 PMID: 1405490
  10. Mechanism of action of regulatory proteins encoded by complex retroviruses.
    Microbiol Rev. 1992 Sep;56(3):375-94 PMID: 1406488
  11. Relationship of human immunodeficiency virus type 1 sequence heterogeneity to stage of disease.
    Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10247-51 PMID: 1438212
  12. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene.
    Science. 1992 Dec 18;258(5090):1938-41 PMID: 1470917
  13. Cohort study of natural transmission and two methods for control of caprine arthritis-encephalitis virus infection in goats on a California dairy.
    Am J Vet Res. 1992 Dec;53(12):2386-95 PMID: 1335709
  14. Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus.
    J Virol. 1993 Feb;67(2):902-12 PMID: 8380472
  15. The immunopathogenesis of human immunodeficiency virus infection.
    N Engl J Med. 1993 Feb 4;328(5):327-35 PMID: 8093551
  16. The effect of vpu on HIV-1-induced syncytia formation.
    J Acquir Immune Defic Syndr. 1993 Feb;6(2):135-41 PMID: 8094456
  17. The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4.
    J Virol. 1993 Mar;67(3):1511-6 PMID: 8437228
  18. A distinct African lentivirus from Sykes' monkeys.
    J Virol. 1993 Mar;67(3):1517-28 PMID: 8382307
  19. Induction of cell differentiation by human immunodeficiency virus 1 vpr.
    Cell. 1993 Feb 26;72(4):541-50 PMID: 8440020
  20. Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.
    EMBO J. 1993 Feb;12(2):703-13 PMID: 8095017
  21. Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant.
    J Virol. 1993 May;67(5):2592-600 PMID: 8386267
  22. Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates.
    Science. 1993 Apr 30;260(5108):689-92 PMID: 8097595
  23. Lentivirus genomic organization: the complete nucleotide sequence of the env gene region of equine infectious anemia virus.
    Virology. 1986 Dec;155(2):309-21 PMID: 2431539
  24. The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release.
    J Virol. 1990 Feb;64(2):621-9 PMID: 2404139
  25. Analysis of envelope changes acquired by SIVmac239 during neuroadaption in rhesus macaques.
    Virology. 1993 Aug;195(2):616-26 PMID: 8337835
  26. Genotypic and phenotypic characterization of HIV-1 patients with primary infection.
    Science. 1993 Aug 27;261(5125):1179-81 PMID: 8356453
  27. Intracerebral hemorrhages and syncytium formation induced by endothelial cell infection with a murine leukemia virus.
    J Virol. 1993 Oct;67(10):6015-24 PMID: 8396666
  28. Viral determinants of simian immunodeficiency virus (SIV) virulence in rhesus macaques assessed by using attenuated and pathogenic molecular clones of SIVmac.
    J Virol. 1993 Oct;67(10):6047-55 PMID: 8371353
  29. Efficiency of viral DNA synthesis during infection of permissive and nonpermissive cells with vif-negative human immunodeficiency virus type 1.
    J Virol. 1993 Oct;67(10):6322-6 PMID: 8371360
  30. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.
    Nature. 1993 Oct 14;365(6447):666-9 PMID: 8105392
  31. Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4.
    J Virol. 1993 Dec;67(12):7238-45 PMID: 8230446
  32. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism.
    Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10474-8 PMID: 7504264
  33. The human immunodeficiency virus type 1 (HIV-1) vif protein is located in the cytoplasm of infected cells and its effect on viral replication is equivalent in HIV-2.
    AIDS Res Hum Retroviruses. 1993 Oct;9(10):1025-30 PMID: 8280477
  34. Towards a structure of the HIV-1 envelope glycoprotein gp120: an immunochemical approach.
    Philos Trans R Soc Lond B Biol Sci. 1993 Oct 29;342(1299):83-8 PMID: 7904352
  35. Subcellular localization of the Vif protein of human immunodeficiency virus type 1.
    J Virol. 1994 Feb;68(2):704-12 PMID: 8289374
  36. The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells.
    J Biol Chem. 1994 Feb 11;269(6):3917-20 PMID: 7905875
  37. Reduced nuclear import of human immunodeficiency virus type 1 preintegration complexes in the presence of a prototypic nuclear targeting signal.
    J Virol. 1994 Mar;68(3):2021-5 PMID: 8107265
  38. Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene.
    J Exp Med. 1994 Mar 1;179(3):797-807 PMID: 8113676
  39. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.
    Cell. 1994 Mar 11;76(5):853-64 PMID: 8124721
  40. Functions of HIV envelope glycans.
    Trends Biochem Sci. 1994 Feb;19(2):65-70 PMID: 8160267
  41. Human immunodeficiency virus envelope glycoproteins.
    J Acquir Immune Defic Syndr. 1994;7 Suppl 1:S14-20 PMID: 8182509
  42. Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity.
    J Virol. 1994 Jun;68(6):3478-85 PMID: 8189487
  43. The Rev protein of visna virus is localized to the nucleus of infected cells.
    Virology. 1994 Jul;202(1):485-90 PMID: 8009861
  44. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.
    Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7311-5 PMID: 8041786
  45. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome.
    Science. 1987 Feb 13;235(4790):790-3 PMID: 3643650
  46. Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein.
    Cell. 1987 Feb 27;48(4):691-701 PMID: 3643816
  47. An inducible transcription factor activates expression of human immunodeficiency virus in T cells.
    Nature. 1987 Apr 16-22;326(6114):711-3 PMID: 3031512
  48. pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane.
    Cell. 1987 Jun 5;49(5):659-68 PMID: 3107838
  49. Nucleotide sequence analysis of equine infectious anemia virus proviral DNA.
    Virology. 1987 Jun;158(2):300-12 PMID: 3035786
  50. Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses.
    Nature. 1987 Aug 6-12;328(6130):539-43 PMID: 3497350
  51. Replication and cytopathic effects of ovine lentivirus strains in alveolar macrophages correlate with in vivo pathogenicity.
    J Virol. 1987 Dec;61(12):4038-42 PMID: 2824834
  52. The visna virus genome: evidence for a hypervariable site in the env gene and sequence homology among lentivirus envelope proteins.
    J Virol. 1987 Dec;61(12):4046-54 PMID: 2824836
  53. Localization of sequences responsible for trans-activation of the equine infectious anemia virus long terminal repeat.
    J Virol. 1988 Jan;62(1):120-6 PMID: 2824840
  54. Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.
    Proc Natl Acad Sci U S A. 1990 Feb;87(3):1198-202 PMID: 2405396
  55. HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence.
    Cell. 1990 Feb 23;60(4):675-83 PMID: 2406030
  56. Characterization of HIV-1 neutralization escape mutants.
    AIDS. 1989 Dec;3(12):777-84 PMID: 2483618
  57. Nucleotide sequence and genome organization of biologically active proviruses of the bovine immunodeficiency-like virus.
    Virology. 1990 Apr;175(2):391-409 PMID: 2183467
  58. Pathogenesis of caprine arthritis encephalitis virus. Cellular localization of viral transcripts in tissues of infected goats.
    Am J Pathol. 1990 Apr;136(4):843-54 PMID: 2327471
  59. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure.
    Cell. 1990 Apr 20;61(2):213-22 PMID: 2331748
  60. Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1.
    J Virol. 1990 Jun;64(6):2519-29 PMID: 2335812
  61. Human immunodeficiency virus vpr product is a virion-associated regulatory protein.
    J Virol. 1990 Jun;64(6):3097-9 PMID: 2139896
  62. Genetic organization of a chimpanzee lentivirus related to HIV-1.
    Nature. 1990 May 24;345(6273):356-9 PMID: 2188136
  63. The simian immunodeficiency viruses.
    Annu Rev Immunol. 1990;8:557-78 PMID: 2188674
  64. Cellular localization of an HIV-1 antigen in subacute AIDS encephalitis using an improved double-labeling immunohistochemical method.
    Am J Pathol. 1990 May;136(5):1085-92 PMID: 1693470
  65. Macrophage-HIV interaction: viral isolation and target cell tropism.
    AIDS. 1990 Mar;4(3):221-8 PMID: 2112397
  66. Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA.
    J Virol. 1990 Jul;64(7):3207-11 PMID: 2191147
  67. Equine infectious anemia virus (EIAV) humoral responses of recipient ponies and antigenic variation during persistent infection.
    Arch Virol. 1990;111(3-4):199-212 PMID: 2162160
  68. In vitro isolation of a neutralization escape mutant of equine infectious anemia virus (EIAV).
    Arch Virol. 1990;111(3-4):275-80 PMID: 1693846
  69. Caprine arthritis encephalitis lentivirus transmission and disease.
    Curr Top Microbiol Immunol. 1990;160:61-75 PMID: 2162288
  70. Cloning and characterization of cDNAs encoding equine infectious anemia virus tat and putative Rev proteins.
    J Virol. 1990 Aug;64(8):3716-25 PMID: 2164593
  71. Protein sequence comparisons show that the 'pseudoproteases' encoded by poxviruses and certain retroviruses belong to the deoxyuridine triphosphatase family.
    Nucleic Acids Res. 1990 Jul 25;18(14):4105-10 PMID: 2165588
  72. Specific tropism of HIV-1 for microglial cells in primary human brain cultures.
    Science. 1990 Aug 3;249(4968):549-53 PMID: 2200125
  73. Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action.
    Genes Dev. 1990 Jun;4(6):1014-22 PMID: 2116986
  74. Functions of the auxiliary gene products of the human immunodeficiency virus type 1.
    Virology. 1990 Sep;178(1):1-5 PMID: 2202146
  75. Open reading frame vpr of simian immunodeficiency virus encodes a virion-associated protein.
    J Virol. 1990 Nov;64(11):5688-93 PMID: 2145446
  76. Origin of vpx in lentiviruses.
    Nature. 1990 Sep 27;347(6291):341-2 PMID: 2145513
  77. Visna virus encodes a post-transcriptional regulator of viral structural gene expression.
    Proc Natl Acad Sci U S A. 1990 Oct;87(19):7497-501 PMID: 2170981
  78. Nucleotide sequence and transcriptional analysis of molecular clones of CAEV which generate infectious virus.
    Virology. 1990 Nov;179(1):347-64 PMID: 2171210
  79. Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.
    Genes Dev. 1990 Aug;4(8):1357-64 PMID: 2227413
  80. The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages.
    Proc Natl Acad Sci U S A. 1990 Oct;87(20):8080-4 PMID: 2236020
  81. Increased human immunodeficiency virus (HIV) expression in chronically infected U937 cells upon in vitro differentiation by hydroxyvitamin D3: roles of interferon and tumor necrosis factor in regulation of HIV production.
    J Virol. 1990 Dec;64(12):5874-82 PMID: 1700829
  82. Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.
    Genes Dev. 1990 Nov;4(11):1875-85 PMID: 2276622
  83. Selection of genetic variants of simian immunodeficiency virus in persistently infected rhesus monkeys.
    J Virol. 1991 Apr;65(4):1843-54 PMID: 2002545
  84. The histopathology of maedi a slow, viral pneumonia of sheep.
    Vet Pathol. 1971;8(1):63-80 PMID: 5157932
  85. Isolation of a virus from cattle with persistent lymphocytosis.
    J Natl Cancer Inst. 1972 Dec;49(6):1649-57 PMID: 4630608
  86. Antigenic drift of equine infectious anemia virus in chronically infected horses.
    Arch Gesamte Virusforsch. 1973;41(1):1-10 PMID: 4123810
  87. Human immunodeficiency virus type 2 vpx protein augments viral infectivity.
    Virology. 1991 Sep;184(1):197-209 PMID: 1714662
  88. Maedi and visna in sheep.
    Front Biol. 1976;44:17-43 PMID: 182560
  89. The pathology of visna and maedi in sheep.
    Front Biol. 1976;44:61-96 PMID: 955159
  90. Pathogenesis of visna. I. Sequential virologic, serologic, and pathologic studies.
    Lab Invest. 1976 Oct;35(4):402-12 PMID: 185458
  91. Antigenic shift of visna virus in persistently infected sheep.
    Science. 1977 Jul 22;197(4301):376-8 PMID: 195339
  92. Chronic arthritis in goats caused by a retrovirus.
    Science. 1980 Feb 29;207(4434):997-9 PMID: 6153243
  93. Alterations in the levels of deoxyuridine triphosphatase, uracil-DNA glycosylase and AP endonuclease during the cell cycle.
    Exp Cell Res. 1980 Feb;125(2):493-7 PMID: 6101556
  94. Biological characterization of the virus causing leukoencephalitis and arthritis in goats.
    J Gen Virol. 1980 Sep;50(1):69-79 PMID: 6255088
  95. Biochemical characterization of the virus causing leukoencephalitis and arthritis in goats.
    J Gen Virol. 1980 Oct;50(2):423-7 PMID: 6161991
  96. Ovine progressive pneumonia: pathologic and virologic studies on the naturally occurring disease.
    Am J Vet Res. 1981 Sep;42(9):1554-9 PMID: 6275756
  97. Slow virus replication: the role of macrophages in the persistence and expression of visna viruses of sheep and goats.
    J Gen Virol. 1982 Apr;59(Pt 2):345-56 PMID: 6281373
  98. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
    Science. 1983 May 20;220(4599):868-71 PMID: 6189183
  99. Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes to macrophages.
    Infect Immun. 1983 Jul;41(1):67-73 PMID: 6862634
  100. Maedi-visna control in sheep. I. Artificial rearing of colostrum-deprived lambs.
    Vet Microbiol. 1983 Apr;8(2):179-85 PMID: 6306902
  101. Susceptibility of blood-derived monocytes and macrophages to caprine arthritis-encephalitis virus.
    Infect Immun. 1983 Aug;41(2):837-40 PMID: 6307885
  102. Transmission of naturally occurring lymphoma in macaque monkeys.
    Proc Natl Acad Sci U S A. 1983 Aug;80(16):5085-9 PMID: 6576377
  103. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.
    Science. 1984 May 4;224(4648):500-3 PMID: 6200936
  104. Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus.
    Science. 1985 Jan 11;227(4683):173-7 PMID: 2981428
  105. Global survey of serological evidence of caprine arthritis-encephalitis virus infection.
    Vet Rec. 1984 Nov 10;115(19):493-5 PMID: 6097015
  106. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques.
    Science. 1985 Jun 7;228(4704):1201-4 PMID: 3159089
  107. The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat.
    Cell. 1985 Jul;41(3):813-23 PMID: 2988790
  108. HTLV-III-neutralizing antibodies in patients with AIDS and AIDS-related complex.
    Nature. 1985 Jul 4-10;316(6023):72-4 PMID: 2989707
  109. Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection.
    J Exp Med. 1993 Jun 1;177(6):1561-6 PMID: 8098729
  110. Immunopathogenesis of HIV infection.
    J Acquir Immune Defic Syndr. 1993 Jun;6(6):655-62 PMID: 8098755
  111. Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection.
    J Virol. 1993 Jun;67(6):3345-56 PMID: 8497055
  112. The PU.1/Spi-1 proto-oncogene is a transcriptional regulator of a lentivirus promoter.
    J Virol. 1993 Jul;67(7):3885-90 PMID: 8389910
  113. Human immunodeficiency virus type 1 Vpu has a CD4- and an envelope glycoprotein-independent function.
    J Virol. 1993 Jul;67(7):4190-4 PMID: 8510220
  114. Vpx of simian immunodeficiency virus is localized primarily outside the virus core in mature virions.
    J Virol. 1993 Jul;67(7):4386-90 PMID: 8510227
  115. Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation.
    Nature. 1993 Jun 24;363(6431):741-4 PMID: 8515819
  116. Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells.
    J Virol. 1993 Aug;67(8):4945-55 PMID: 8331734
  117. Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein.
    J Virol. 1993 Aug;67(8):5056-61 PMID: 8331740
  118. Antigenic variation of molecularly cloned SIVmac239 during persistent infection in a rhesus macaque.
    Virology. 1993 Aug;195(2):406-12 PMID: 8337820
  119. Characterization and molecular cloning of a bovine lentivirus related to human immunodeficiency virus.
    Nature. 1987 Nov 26-Dec 2;330(6146):388-91 PMID: 3683555
  120. Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay.
    Nature. 1987 Nov 26-Dec 2;330(6146):391-5 PMID: 2825023
  121. Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I.
    Science. 1987 Dec 11;238(4833):1575-8 PMID: 2825351
  122. Isolation of simian immunodeficiency virus from African green monkeys and seroepidemiologic survey of the virus in various non-human primates.
    Int J Cancer. 1988 Jan 15;41(1):115-22 PMID: 2447023
  123. Lentivirus-induced lymphoproliferative disease. Comparative pathogenicity of phenotypically distinct ovine lentivirus strains.
    Am J Pathol. 1988 Jan;130(1):80-90 PMID: 3337213
  124. Interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus.
    EMBO J. 1987 Dec 1;6(12):3761-70 PMID: 3428273
  125. Spontaneous interferon production by pulmonary leukocytes is associated with lentivirus-induced lymphoid interstitial pneumonia.
    J Immunol. 1988 Feb 1;140(3):779-85 PMID: 2448376
  126. Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat.
    J Virol. 1988 Mar;62(3):673-9 PMID: 2828663
  127. Antigenic variation in lentiviral diseases.
    Annu Rev Immunol. 1988;6:139-59 PMID: 2838047
  128. Human and simian immunodeficiency retroviruses: activation and differential transactivation of gene expression.
    AIDS Res Hum Retroviruses. 1988 Jun;4(3):175-86 PMID: 2840105
  129. Antigenic variation of neutralization-sensitive epitopes of caprine arthritis-encephalitis lentivirus during persistent arthritis.
    J Virol. 1988 Sep;62(9):3488-92 PMID: 2457116
  130. HIV infection does not require endocytosis of its receptor, CD4.
    Cell. 1988 Sep 9;54(6):865-74 PMID: 3261635
  131. Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes.
    Proc Natl Acad Sci U S A. 1985 Jul;82(14):4813-7 PMID: 2991896
  132. Slow, persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow.
    Proc Natl Acad Sci U S A. 1985 Oct;82(20):7086-90 PMID: 2996004
  133. Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from wild-caught African green monkeys.
    Science. 1985 Nov 22;230(4728):951-4 PMID: 2997923
  134. A Trojan Horse mechanism for the spread of visna virus in monocytes.
    Virology. 1985 Nov;147(1):231-6 PMID: 2998068
  135. Restricted replication of lentiviruses. Visna viruses induce a unique interferon during interaction between lymphocytes and infected macrophages.
    J Exp Med. 1985 Dec 1;162(6):1954-69 PMID: 2415660
  136. Persistent expression of Ia antigen and viral genome in visna-maedi virus-induced inflammatory cells. Possible role of lentivirus-induced interferon.
    J Exp Med. 1985 Dec 1;162(6):1970-82 PMID: 2415661
  137. Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages.
    J Virol. 1986 Apr;58(1):67-74 PMID: 3005660
  138. A new HTLV-III/LAV protein encoded by a gene found in cytopathic retroviruses.
    Science. 1986 Mar 28;231(4745):1546-9 PMID: 3006243
  139. Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions.
    Science. 1986 Mar 28;231(4745):1549-53 PMID: 3006244
  140. Identification of HTLV-III/LAV sor gene product and detection of antibodies in human sera.
    Science. 1986 Mar 28;231(4745):1553-5 PMID: 3006245
  141. Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1.
    Science. 1986 May 9;232(4751):755-9 PMID: 3008338
  142. AIDS retrovirus (ARV-2) clone replicates in transfected human and animal fibroblasts.
    Science. 1986 May 23;232(4753):998-1001 PMID: 3010461
  143. Isolation of an HTLV-III-related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeys.
    Nature. 1986 May 22-28;321(6068):435-7 PMID: 3012358
  144. Human T-cell lymphotropic virus type III shares sequence homology with a family of pathogenic lentiviruses.
    Proc Natl Acad Sci U S A. 1986 Jun;83(11):4007-11 PMID: 2424014
  145. Isolation of a T-lymphotropic retrovirus from naturally infected sooty mangabey monkeys (Cercocebus atys).
    Proc Natl Acad Sci U S A. 1986 Jul;83(14):5286-90 PMID: 3014542
  146. Isolation of a new human retrovirus from West African patients with AIDS.
    Science. 1986 Jul 18;233(4761):343-6 PMID: 2425430
  147. HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA.
    Cell. 1986 Sep 12;46(6):807-17 PMID: 3638988
  148. Seroepidemiologic survey of captive Old-World primates for antibodies to human and simian retroviruses, and isolation of a lentivirus from sooty mangabeys (Cercocebus atys).
    Int J Cancer. 1986 Oct 15;38(4):563-74 PMID: 2428760
  149. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.
    Cell. 1986 Nov 7;47(3):333-48 PMID: 3094962
  150. Isolation of a lentivirus from a macaque with lymphoma: comparison with HTLV-III/LAV and other lentiviruses.
    J Virol. 1986 Nov;60(2):483-90 PMID: 3021982
  151. Identification of a putative cellular receptor for the lentivirus visna virus.
    J Gen Virol. 1991 Aug;72 ( Pt 8):1905-11 PMID: 1651984
  152. Neutralization-resistant antigenic variants of caprine arthritis-encephalitis lentivirus associated with progressive arthritis.
    J Infect Dis. 1991 Oct;164(4):679-85 PMID: 1654355
  153. Identification of cell membrane proteins that bind visna virus.
    J Virol. 1991 Nov;65(11):6137-43 PMID: 1656089
  154. Pathological changes in the lungs and mammary glands of sheep and their relationship with maedi-visna infection.
    Vet Rec. 1991 Jul 20;129(3):51-4 PMID: 1656581
  155. A highly divergent simian immunodeficiency virus (SIVstm) recovered from stored stump-tailed macaque tissues.
    J Virol. 1991 Dec;65(12):7061-5 PMID: 1942258
  156. Human and ovine lentiviral infections compared.
    Comp Immunol Microbiol Infect Dis. 1991;14(4):277-87 PMID: 1684142
  157. Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes.
    J Virol. 1992 Jan;66(1):226-34 PMID: 1727486
  158. Distinct subsets of retroviruses encode dUTPase.
    J Virol. 1992 Mar;66(3):1791-4 PMID: 1310783
  159. Lack of HIV-1 V3 region sequence diversity in two haemophiliac patients infected with a putative biologic clone of HIV-1.
    AIDS. 1991 Oct;5(10):1185-7 PMID: 1786146
  160. Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants.
    Science. 1992 Feb 28;255(5048):1134-7 PMID: 1546316
  161. Conservation of amino-acid sequence motifs in lentivirus Vif proteins.
    Virus Genes. 1992 Jan;6(1):95-102 PMID: 1312756
  162. Ovine lentivirus is macrophagetropic and does not replicate productively in T lymphocytes.
    J Virol. 1992 May;66(5):2679-88 PMID: 1348546
  163. Pathologic features of SIV-induced disease and the association of macrophage infection with disease evolution.
    AIDS Res Hum Retroviruses. 1992 Mar;8(3):327-37 PMID: 1571193
  164. Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytetropic parental virus: pathogenesis of infection in macaques.
    J Virol. 1992 Jun;66(6):3550-6 PMID: 1583723
  165. Molecular mechanisms of visna virus Tat: identification of the targets for transcriptional activation and evidence for a post-transcriptional effect.
    Virology. 1992 Jun;188(2):438-50 PMID: 1316669
  166. Persistent infection of rabbits with bovine immunodeficiency-like virus.
    J Virol. 1992 Jul;66(7):4518-24 PMID: 1318416
  167. HIV-1 genomic RNA diversification following sexual and parenteral virus transmission.
    Virology. 1992 Jul;189(1):103-10 PMID: 1376536
  168. Cellular transcription factors involved in the regulation of HIV-1 gene expression.
    AIDS. 1992 Apr;6(4):347-63 PMID: 1616633
  169. Isolation and characterization of a new chimpanzee lentivirus (simian immunodeficiency virus isolate cpz-ant) from a wild-captured chimpanzee.
    AIDS. 1992 May;6(5):447-51 PMID: 1616649
  170. Rapid generation of sequence variation during primary HIV-1 infection.
    AIDS. 1992 May;6(5):453-60 PMID: 1616650
  171. Infection of Macaca nemestrina by human immunodeficiency virus type-1.
    Science. 1992 Jul 3;257(5066):103-6 PMID: 1621083
  172. Envelope glycoprotein and CD4 independence of vpu-facilitated human immunodeficiency virus type 1 capsid export.
    J Virol. 1992 Aug;66(8):5119-26 PMID: 1629967
  173. Purification of the human immunodeficiency virus type 1 enhancer and TAR binding proteins EBP-1 and UBP-1.
    EMBO J. 1988 Jul;7(7):2117-30 PMID: 3138113
  174. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.
    Science. 1988 Sep 23;241(4873):1632-9 PMID: 2971269
  175. Isolation and characterization of simian immunodeficiency virus from mandrills in Africa and its relationship to other human and simian immunodeficiency viruses.
    J Virol. 1988 Nov;62(11):4044-50 PMID: 3172337
  176. Microglia in the giant cell encephalitis of acquired immune deficiency syndrome: proliferation, infection and fusion.
    Acta Neuropathol. 1988;76(4):373-9 PMID: 3176903
  177. Human immunodeficiency virus type 2 long terminal repeat: analysis of regulatory elements.
    Proc Natl Acad Sci U S A. 1988 Dec;85(24):9753-7 PMID: 2849115
  178. Cellular localization of simian immunodeficiency virus in lymphoid tissues. I. Immunohistochemistry and electron microscopy.
    Am J Pathol. 1989 Feb;134(2):373-83 PMID: 2537016
  179. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA.
    Nature. 1989 Mar 16;338(6212):254-7 PMID: 2784194
  180. Expression of viral antigens in the central nervous system of visna-infected sheep: an immunohistochemical study on experimental visna induced by virus strains of increased neurovirulence.
    Acta Neuropathol. 1989;77(3):299-306 PMID: 2538043
  181. CD4-independent infection of human neural cells by human immunodeficiency virus type 1.
    J Virol. 1989 Jun;63(6):2527-33 PMID: 2786088
  182. Lentivirus-induced interferon inhibits maturation and proliferation of monocytes and restricts the replication of caprine arthritis-encephalitis virus.
    J Virol. 1989 Jun;63(6):2578-84 PMID: 2470918
  183. Sequences in the visna virus long terminal repeat that control transcriptional activity and respond to viral trans-activation: involvement of AP-1 sites in basal activity and trans-activation.
    J Virol. 1989 Jul;63(7):3001-15 PMID: 2542608
  184. A retroviral Cys-Xaa2-Cys-Xaa4-His-Xaa4-Cys peptide binds metal ions: spectroscopic studies and a proposed three-dimensional structure.
    Proc Natl Acad Sci U S A. 1989 Jun;86(11):4047-51 PMID: 2786206
  185. Biology and pathogenesis of lentiviruses.
    J Gen Virol. 1989 Jul;70 ( Pt 7):1617-39 PMID: 2544657
  186. Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein.
    J Virol. 1989 Sep;63(9):3784-91 PMID: 2788224
  187. Effects of long terminal repeat mutations on human immunodeficiency virus type 1 replication.
    J Virol. 1989 Sep;63(9):4115-9 PMID: 2760991
  188. Regulation of the visna virus long terminal repeat in macrophages involves cellular factors that bind sequences containing AP-1 sites.
    Mol Cell Biol. 1989 Jun;9(6):2728-33 PMID: 2548087
  189. Nucleotide sequence and genomic organization of feline immunodeficiency virus.
    Proc Natl Acad Sci U S A. 1989 Aug;86(15):5743-7 PMID: 2762293
  190. Infection of monocyte-derived macrophages with human immunodeficiency virus type 1 (HIV-1). Monocyte-tropic and lymphocyte-tropic strains of HIV-1 show distinctive patterns of replication in a panel of cell types.
    J Exp Med. 1989 Oct 1;170(4):1149-63 PMID: 2571666
  191. Human immunodeficiency virus 1. Predominance of a group-specific neutralizing epitope that persists despite genetic variation.
    J Exp Med. 1989 Nov 1;170(5):1681-95 PMID: 2478654
  192. Isolates of human immunodeficiency virus type 1 from the brain may constitute a special group of the AIDS virus.
    Proc Natl Acad Sci U S A. 1989 Nov;86(21):8575-9 PMID: 2813413
  193. Identification of HIV-1 vpr product and function.
    J Acquir Immune Defic Syndr. 1990;3(1):11-8 PMID: 2136707
  194. Pathobiology of lentivirus infections of sheep and goats.
    Virus Res. 1994 May;32(2):139-54 PMID: 8067051
  195. Bovine immunodeficiency virus: molecular biology and virus-host interactions.
    Virus Res. 1994 May;32(2):155-81 PMID: 8067052
  196. Pathogenic diversity of simian immunodeficiency viruses.
    Virus Res. 1994 May;32(2):183-203 PMID: 8067053
  197. Visna virus Tat protein: a potent transcription factor with both activator and suppressor domains.
    J Virol. 1994 Oct;68(10):6137-46 PMID: 8083955
  198. A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge.
    J Virol. 1994 Nov;68(11):7021-9 PMID: 7933084
  199. Neurovirulent simian immunodeficiency virus replicates productively in endothelial cells of the central nervous system in vivo and in vitro.
    J Virol. 1994 Dec;68(12):8202-8 PMID: 7966612
  200. Structural rearrangements in the transmembrane glycoprotein after receptor binding.
    Immunol Rev. 1994 Aug;140:93-104 PMID: 7821930
  201. Ovine lentivirus expression and disease. Virus replication, but not entry, is restricted to macrophages of specific tissues.
    Am J Pathol. 1995 Jan;146(1):250-63 PMID: 7531949
  202. HIV-1 infection of human brain-derived microvascular endothelial cells in vitro.
    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):437-45 PMID: 7697439
  203. Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus.
    J Virol. 1995 May;69(5):2737-44 PMID: 7707496
  204. Human immunodeficiency virus vpr gene encodes a virion-associated protein.
    AIDS Res Hum Retroviruses. 1990 Nov;6(11):1265-71 PMID: 2150318
  205. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef.
    Nature. 1991 Apr 11;350(6318):508-11 PMID: 2014052
  206. Linker-scanning mutational analysis of the transcriptional activity of the human immunodeficiency virus type 1 long terminal repeat.
    J Virol. 1991 May;65(5):2436-44 PMID: 2016766
  207. Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs.
    Genes Dev. 1991 May;5(5):808-19 PMID: 1827422
  208. Importance of the nef gene for maintenance of high virus loads and for development of AIDS.
    Cell. 1991 May 17;65(4):651-62 PMID: 2032289
  209. Mutational analysis of the equine infectious anemia virus Tat-responsive element.
    J Virol. 1991 Jul;65(7):3468-74 PMID: 1645778
  210. Reduced binding of TFIID to transcriptionally compromised mutants of VP16.
    Nature. 1991 Jun 13;351(6327):588-90 PMID: 1646402
  211. Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IID.
    Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5124-8 PMID: 1828892
  212. Cloning and characterization of a novel sequence-specific DNA-binding protein recognizing the negative regulatory element (NRE) region of the HIV-1 long terminal repeat.
    Gene. 1991 May 30;101(2):171-6 PMID: 2055486
  213. Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS.
    Am J Pathol. 1991 Jul;139(1):29-35 PMID: 1853937
  214. Galactosyl ceramide or a derivative is an essential component of the neural receptor for human immunodeficiency virus type 1 envelope glycoprotein gp120.
    Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7131-4 PMID: 1871126
Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.9.1.100
Published
1996-01-00
Pages
100-17
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC172884
Subset
IM
External Links
PubMed source DOI: 10.1128/CMR.9.1.100 PMC Full Text View journal details
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