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PMID: 8537466 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Role of apoptosis in HIV disease pathogenesis.

Journal of clinical immunology ·Vol. 15 ·No. 5 ·1995-09-00 ·Pages 217-31

Oyaizu N, Pahwa S

Abstract

After approximately one and a half decades of intensive studies, the exact mechanisms to explain HIV-mediated cytopathicity are still enigmatic and need closer scrutiny. There has been a dichotomy between virological and immunological viewpoints in understanding HIV-mediated cytopathicity, the former emphasizing a killing of infected cells by HIV-1 and the latter emphasizing indirect mechanisms wherein HIV or its soluble component(s) alter CD4 T-cell function and induce susceptibility to apoptosis. Accumulating evidence points to the notion that apoptosis might be a major contributor to the depletion of CD4 T-cells in HIV infection. This review summarizes current information about the regulatory mechanisms of T-cell apoptosis and the role of apoptosis in HIV pathogenesis with the goal of providing an integrated view of HIV cytopathicity.

MeSH Terms
Animals Apoptosis/physiology HIV Infections/etiology,pathology Humans T-Lymphocytes/pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Oyaizu N
Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York, New York 11030, USA.
Pahwa S
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/BF01540879
Published
1995-09-00
Pages
217-31
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
Grants
NIAID NIH HHS · AI28281 · United States
NIDA NIH HHS · DA05061 · United States
NICHD NIH HHS · HD26606 · United States
External Links
PubMed source DOI: 10.1007/BF01540879 View journal details
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