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PMID: 8464732 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.

Nucleic acids research ·Vol. 21 ·No. 6 ·1993-03-25 ·Pages 1409-17

Tunnacliffe A, Liu L, Moore JK, Leversha MA, Jackson MS, Papi L, Ferguson-Smith MA, Thiesen HJ, Ponder BA

Abstract

Two related zinc finger (ZNF) gene clusters from the pericentromeric region of human chromosome 10, defined by cDNAs of the KOX series, have been cloned in yeast artificial chromosomes (YACs). The two clusters evolved by duplication of an ancestral gene cluster before the divergence of the human and great ape lineages. Included in cluster A are the ZNF gene sequences ZNF11A, ZNF33A, and ZNF37A, while cluster B comprises the related sequences ZNF11B, ZNF33B and ZNF37B. Genes from both clusters are expressed: cDNAs KOX2, KOX31 and KOX21 derive from ZNF11B, ZNF33A and ZNF37A, respectively. Further YACs have been isolated which link ZNF11A and ZNF33A to another gene, ZNF25, defined by cDNA clone KOX19. Therefore ZNF25 also forms part of cluster A, but has no counterpart in cluster B. Surprisingly, the KOX ZNF gene clusters are located on opposite sides of the centromere: cluster A maps to 10p11.2, while cluster B is in 10q11.2. This suggests the occurrence during primate evolution of a previously undescribed pericentric inversion subsequent to the cluster duplication. The evolution of this subset of KOX ZNF genes has therefore involved three types of genetic event: local gene duplication, gene cluster duplication, and chromosome rearrangement.

Related Genes
KOX19 KOX2 KOX21 KOX31 ZNF11A ZNF11B ZNF25 ZNF33A
MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Centromere/ultrastructure Chromosome Inversion Chromosomes, Human, Pair 10/ultrastructure Cloning, Molecular Gene Expression Genes Genetic Linkage Humans In Situ Hybridization Molecular Sequence Data Multigene Family Oligodeoxyribonucleotides/chemistry Primates/genetics RNA, Messenger/genetics Restriction Mapping Sequence Alignment Species Specificity Zinc Fingers
Chemicals
Oligodeoxyribonucleotides RNA, Messenger
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Tunnacliffe A
CRC Human Cancer Genetics Research Group, University of Cambridge, UK.
Liu L
Moore J K
Leversha M A
Jackson M S
Papi L
Ferguson-Smith M A
Thiesen H J
Ponder B A
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/21.6.1409
Published
1993-03-25
Pages
1409-17
Language
English
Region
England
NLM ID
0411011
PMCID
PMC309326
Subset
IM
Databases
GENBANK
X68684, X68685, X68686, X68687, X68688, X68689, X69115, X69116
External Links
PubMed source DOI: 10.1093/nar/21.6.1409 PMC Full Text View journal details
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