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PMID: 2026422 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), map to chromosome 7p22-p21 and 12q24.33, respectively.

Human genetics ·Vol. 86 ·No. 6 ·1991-04-00 ·Pages 585-90

Seite P, Huebner K, Rousseau-Merck MF, Berger R, Thiesen HJ

Abstract

Two members of the human zinc finger Krüppel family, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), have been localized by somatic cell hybrid analysis and in situ chromosomal hybridization. The presence of individual human zinc finger genes in mouse-human hybrid DNAs was correlated with the presence of specific human chromosomes or regions of chromosomes in the corresponding cell hybrids. Analysis of such mouse-human hybrid DNAs allowed the assignment of the ZNF 12 (KOX 3) gene to chromosome region 7p. The ZNF 26 (KOX 20) gene segregated with chromosome region 12q13-qter. The zinc finger genes ZNF 12 (KOX 3) and ZNF 26 (KOX 20) were localized by in situ chromosomal hybridization to human chromosome regions 7p22-21 and 12q24.33, respectively. These genes and the previously mapped ZNF 24 (KOX 17) and ZNF 29 (KOX 26) genes, are found near fragile sites.

Related Genes
KOX20 KOX3 ZNF12 ZNF26
MeSH Terms
Amino Acid Sequence Animals Chromosome Banding Chromosome Mapping Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 7 Humans Hybrid Cells Mice Mitosis Molecular Sequence Data Multigene Family Nucleic Acid Hybridization Zinc Fingers/genetics
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Seite P
INSERM U, 301 Institut de Génétique Moléculaire, Paris, France.
Huebner K
Rousseau-Merck M F
Berger R
Thiesen H J
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00201545
Published
1991-04-00
Pages
585-90
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
Grants
NCI NIH HHS · CA 21124 · United States
NCI NIH HHS · CA 25875 · United States
External Links
PubMed source DOI: 10.1007/BF00201545 View journal details
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