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PMID: 8432196 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Sex chromosomes, recombination, and chromatin conformation.

Chromosoma ·Vol. 102 ·No. 2 ·1993-01-00 ·Pages 71-80

McKee BD, Handel MA

Abstract

We review what is known about the transcriptional inactivation and condensation of heteromorphic sex chromosomes in contrast to the activation of homomorphic sex chromosomes during meiotic prephase in animals. We relate these cytological and transcriptional features to the recombination status of the sex chromosomes. We propose that sex chromosome condensation is a meiotic adaptation to prevent the initiation of potentially damaging recombination events in nonhomologous regions of the X and Y chromosome.

MeSH Terms
Animals Chromatin/chemistry Dosage Compensation, Genetic Female Male Meiosis Protein Conformation Recombination, Genetic X Chromosome/chemistry,physiology Y Chromosome/chemistry,physiology
Chemicals
Chromatin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McKee B D
Department of Zoology, University of Tennessee, Knoxville 37996.
Handel M A
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Article Info
Journal
Chromosoma
Abbr.
Chromosoma
ISSN
0009-5915
DOI
10.1007/BF00356023
Published
1993-01-00
Pages
71-80
Language
English
Region
Austria
NLM ID
2985138R
Subset
IM
Grants
NIGMS NIH HHS · GM 00522 · United States
NIGMS NIH HHS · GM 40489 · United States
External Links
PubMed source DOI: 10.1007/BF00356023 View journal details
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