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PMID: 8177172 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Computer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis, and evolution.

Microbiological reviews ·Vol. 58 ·No. 1 ·1994-03-00 ·Pages 71-93

Saier MH

Abstract

Three-dimensional structures have been elucidated for very few integral membrane proteins. Computer methods can be used as guides for estimation of solute transport protein structure, function, biogenesis, and evolution. In this paper the application of currently available computer programs to over a dozen distinct families of transport proteins is reviewed. The reliability of sequence-based topological and localization analyses and the importance of sequence and residue conservation to structure and function are evaluated. Evidence concerning the nature and frequency of occurrence of domain shuffling, splicing, fusion, deletion, and duplication during evolution of specific transport protein families is also evaluated. Channel proteins are proposed to be functionally related to carriers. It is argued that energy coupling to transport was a late occurrence, superimposed on preexisting mechanisms of solute facilitation. It is shown that several transport protein families have evolved independently of each other, employing different routes, at different times in evolutionary history, to give topologically similar transmembrane protein complexes. The possible significance of this apparent topological convergence is discussed.

MeSH Terms
Amino Acid Sequence Carrier Proteins/chemistry,genetics,physiology Membrane Proteins/chemistry,genetics,physiology Molecular Sequence Data Phylogeny Software
Chemicals
Carrier Proteins Membrane Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Saier M H
Department of Biology, University of California at San Diego, La Jolla 92093-0116.
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Article Info
Journal
Microbiological reviews
Abbr.
Microbiol Rev
ISSN
0146-0749
DOI
10.1128/mr.58.1.71-93.1994
Published
1994-03-00
Pages
71-93
Language
English
Region
United States
NLM ID
7806086
PMCID
PMC372954
Subset
IM
Grants
NIAID NIH HHS · 2 RO1AI14176 · United States
NIAID NIH HHS · 5RO1AI21702 · United States
External Links
PubMed source DOI: 10.1128/mr.58.1.71-93.1994 PMC Full Text
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