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PMID: 3015599 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Mitochondrial targeting sequences may form amphiphilic helices.

The EMBO journal ·Vol. 5 ·No. 6 ·1986-06-00 ·Pages 1335-42

von Heijne G

Abstract

Twenty three mitochondrial targeting sequences have been analysed with regard to their potential for forming amphiphilic helices. It is shown that most if not all of these sequences can be expected to form helices with high hydrophobic moments in a suitable environment. In the few cases studied so far, the segments of maximal hydrophobic moment coincide closely with 'critical' regions defined by deletions and point mutations.

MeSH Terms
Amino Acid Sequence Enzymes/genetics Humans Mitochondria/enzymology Mutation Protein Conformation Simian virus 40/genetics
Chemicals
Enzymes
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
von Heijne G
References (53)
53 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1986-06-00
Pages
1335-42
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1166945
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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