Home LiteratureArticle Details
PMID: 7731956 Published · ppublish English Comment Journal Article Review

Ethanol, gamma-aminobutyrate type A receptors, and protein kinase C phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 92 ·No. 9 ·1995-04-25 ·Pages 3633-5

Macdonald RL

Abstract

暂无摘要

MeSH Terms
Amino Acid Sequence Animals Brain/physiology Chlorides/metabolism Conserved Sequence Ethanol/pharmacology Neurons/physiology Phosphorylation Protein Kinase C/metabolism Receptors, GABA-A/drug effects,physiology Serine
Chemicals
Chlorides Receptors, GABA-A Ethanol Serine Protein Kinase C
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Macdonald R L
Department of Neurology, University of Michigan Medical Center, Ann Arbor 48104-1687, USA.
References (61)
61 references, click to expand
  1. Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit.
    FEBS Lett. 1992 Nov 23;313(2):113-7 PMID: 1330701
  2. Alcohol and presynaptic inhibition in an isolated spinal cord preparation.
    Arch Neurol. 1973 Jan;28(1):60-3 PMID: 4344473
  3. Site-specific enhancement of gamma-aminobutyric acid-mediated inhibition of neural activity by ethanol in the rat medial septal area.
    J Pharmacol Exp Ther. 1990 Aug;254(2):528-38 PMID: 2166794
  4. Activation of protein kinase C selectively inhibits the gamma-aminobutyric acidA receptor: role of desensitization.
    Mol Pharmacol. 1992 Jun;41(6):1116-23 PMID: 1319547
  5. Function of the alpha 1 beta 2 gamma 2S gamma-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites.
    J Biol Chem. 1992 Dec 25;267(36):25660-3 PMID: 1334482
  6. Effect of ethanol on hippocampal GABA receptors in the rat brain.
    Alcohol. 1989 Mar-Apr;6(2):115-9 PMID: 2540764
  7. Enhancement of current induced by superfusion of GABA in locus coeruleus neurons by pentobarbital, but not ethanol.
    Brain Res. 1990 May 28;517(1-2):324-9 PMID: 2376000
  8. Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex.
    Science. 1980 Aug 8;209(4457):708-10 PMID: 7394531
  9. Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site.
    Proc Natl Acad Sci U S A. 1990 Dec;87(24):9966-70 PMID: 1702226
  10. Recombinant GABAA receptor function and ethanol.
    FEBS Lett. 1993 Jun 14;324(2):140-2 PMID: 8389719
  11. Alcohol modulation of cloned GABAA receptor-channel complex expressed in human kidney cell lines.
    Brain Res. 1993 Dec 17;631(1):143-6 PMID: 7507787
  12. Behavioral evidence for the involvement of gamma-aminobutyric acid in the actions of ethanol.
    Eur J Pharmacol. 1983 Apr 22;89(1-2):53-62 PMID: 6861890
  13. cAMP increases the rate of GABAA receptor desensitization in chick cortical neurons.
    Synapse. 1989;4(2):126-31 PMID: 2551053
  14. Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuron.
    Brain Res. 1990 Jan 22;507(2):332-6 PMID: 2186844
  15. Mechanism of action of ethanol: initial central nervous system actions.
    Pharmacol Rev. 1989 Dec;41(4):489-537 PMID: 2700603
  16. Conversion of protein kinase C from a Ca2+-dependent to an independent form of phorbol ester-binding protein by digestion with trypsin.
    Biochem Biophys Res Commun. 1986 Aug 29;139(1):320-6 PMID: 3464276
  17. Ethanol-induced Cl- flux in rat cerebellar granule cells as measured by a fluorescent probe.
    Brain Res. 1991 Dec 24;568(1-2):55-60 PMID: 1726072
  18. GABAA receptor channels.
    Annu Rev Neurosci. 1994;17:569-602 PMID: 7516126
  19. Cyclic AMP-dependent protein kinase decreases GABAA receptor current in mouse spinal neurons.
    Neuron. 1990 Dec;5(6):789-96 PMID: 2176510
  20. Two novel GABAA receptor subunits exist in distinct neuronal subpopulations.
    Neuron. 1989 Sep;3(3):327-37 PMID: 2561970
  21. Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor.
    J Biol Chem. 1992 Jul 15;267(20):14470-6 PMID: 1321150
  22. The protein kinase C family for neuronal signaling.
    Annu Rev Neurosci. 1994;17:551-67 PMID: 8210187
  23. Emerging neurochemical concepts in the actions of ethanol at ligand-gated ion channels.
    Behav Pharmacol. 1994 Aug;5(4 And 5):383-404 PMID: 11224291
  24. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon.
    J Neurosci. 1992 Mar;12(3):1040-62 PMID: 1312131
  25. Modulation of gamma-aminobutyric acid receptor-channel complex by alcohols.
    J Pharmacol Exp Ther. 1991 Oct;259(1):235-40 PMID: 1656020
  26. GABAergic modulation of ethanol-induced motor impairment.
    J Pharmacol Exp Ther. 1982 Dec;223(3):750-6 PMID: 6292399
  27. Protein kinase C and cAMP-dependent protein kinase phosphorylate the beta subunit of the purified gamma-aminobutyric acid A receptor.
    Proc Natl Acad Sci U S A. 1990 Feb;87(4):1315-8 PMID: 2154739
  28. cAMP and forskolin decrease gamma-aminobutyric acid-gated chloride flux in rat brain synaptoneurosomes.
    Proc Natl Acad Sci U S A. 1989 Apr;86(8):2938-42 PMID: 2468163
  29. gamma-Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes.
    Mol Pharmacol. 1986 May;29(5):497-505 PMID: 3010078
  30. Ethanol potentiation of GABAergic transmission in cultured spinal cord neurons involves gamma-aminobutyric acidA-gated chloride channels.
    J Pharmacol Exp Ther. 1988 Aug;246(2):558-64 PMID: 2457076
  31. GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs.
    EMBO J. 1989 Jun;8(6):1665-70 PMID: 2548852
  32. Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.
    Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2673-7 PMID: 1849271
  33. Effects of ethanol on CA1 and CA3 pyramidal cells in the hippocampal slice preparation: an intracellular study.
    Brain Res. 1987 Jun 23;414(1):22-34 PMID: 3620923
  34. Phosphorylation of gamma-aminobutyrate (GABA)/benzodiazepine receptors by cyclic AMP-dependent protein kinase.
    Biochem J. 1989 Apr 15;259(2):613-6 PMID: 2541695
  35. A selective imidazobenzodiazepine antagonist of ethanol in the rat.
    Science. 1986 Dec 5;234(4781):1243-7 PMID: 3022383
  36. Enhancement of recombinant gamma-aminobutyric acid type A receptor currents by chronic activation of cAMP-dependent protein kinase.
    Mol Pharmacol. 1993 Dec;44(6):1202-10 PMID: 8264557
  37. Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit.
    Neuron. 1991 Jul;7(1):27-33 PMID: 1712603
  38. Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptors.
    Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3658-62 PMID: 7731960
  39. Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons.
    Brain Res. 1988 Jul 12;455(2):377-80 PMID: 2900060
  40. Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology.
    J Neurochem. 1990 May;54(5):1802-4 PMID: 2157817
  41. Role of GABAA receptors in the actions of alcohol and in alcoholism: recent advances.
    Alcohol Alcohol. 1994 Mar;29(2):115-29 PMID: 8080592
  42. Protein kinase C enhances recombinant bovine alpha 1 beta 1 gamma 2L GABAA receptor whole-cell currents expressed in L929 fibroblasts.
    Neuron. 1994 Dec;13(6):1421-31 PMID: 7993633
  43. Ethanol in low doses augments calcium-mediated mechanisms measured intracellularly in hippocampal neurons.
    Science. 1982 Jan 15;215(4530):306-9 PMID: 7053581
  44. Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation.
    Science. 1992 Jul 31;257(5070):661-5 PMID: 1323140
  45. Cerebellar GABAA receptor selective for a behavioural alcohol antagonist.
    Nature. 1990 Aug 16;346(6285):648-51 PMID: 2166916
  46. Ca2+/calmodulin-dependent protein kinase II and protein kinase C phosphorylate a synthetic peptide corresponding to a sequence that is specific for the gamma 2L subunit of the GABAA receptor.
    J Neurochem. 1993 Jul;61(1):375-7 PMID: 8390566
  47. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.
    Nature. 1989 Apr 13;338(6216):582-5 PMID: 2538761
  48. Mechanisms that may underlie the behavioural effects of ethanol.
    Prog Neurobiol. 1991;36(3):171-94 PMID: 1673253
  49. Cyclic AMP-dependent protein kinase decreases gamma-aminobutyric acidA receptor-mediated 36Cl- uptake by brain microsacs.
    J Neurochem. 1991 Aug;57(2):722-5 PMID: 1649259
  50. Ethanol differentially modulates GABAA receptor-mediated chloride currents in hippocampal, cortical, and septal neurons in rat brain slices.
    Synapse. 1994 Oct;18(2):94-103 PMID: 7839317
  51. Phosphorylation of the GABAA receptor by cAMP-dependent protein kinase and by protein kinase C: analysis of the substrate domain.
    Neurochem Res. 1993 Jan;18(1):95-100 PMID: 8385279
  52. Ethanol intoxication and gamma-aminobutyric acid.
    J Neurochem. 1976 Aug;27(2):631-3 PMID: 987162
  53. Regulation of GABAA receptor function by protein kinase C phosphorylation.
    Neuron. 1994 May;12(5):1081-95 PMID: 8185945
  54. A novel alpha subunit in rat brain GABAA receptors.
    Neuron. 1989 Dec;3(6):745-53 PMID: 2561977
  55. Modulation of GABAA receptor-activated current by norepinephrine in cerebellar Purkinje cells.
    Neuroscience. 1992 Dec;51(4):951-60 PMID: 1283212
  56. Ethanol potentiates the GABAA-activated Cl- current in mouse hippocampal and cortical neurons.
    Eur J Pharmacol. 1990 Oct 2;187(1):127-30 PMID: 1703076
  57. Ethanol enhances GABAA receptor-activated chloride currents in chick cerebral cortical neurons.
    Brain Res. 1991 Nov 8;564(1):138-42 PMID: 1723337
  58. GABAA-receptor function in hippocampal cells is maintained by phosphorylation factors.
    Science. 1988 Jul 15;241(4863):339-41 PMID: 2455347
  59. Structural and functional basis for GABAA receptor heterogeneity.
    Nature. 1988 Sep 1;335(6185):76-9 PMID: 2842688
  60. Anticonvulsant profile of drugs which facilitate GABAergic transmission on convulsions mediated by a GABAergic mechanism.
    Neuropharmacology. 1986 Feb;25(2):175-85 PMID: 3010161
  61. Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.
    Nature. 1987 Jul 16-22;328(6127):221-7 PMID: 3037384
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.92.9.3633
Published
1995-04-25
Pages
3633-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC42016
Subset
IM
Corrections
CommentOn
PMID: 7731960
External Links
PubMed source DOI: 10.1073/pnas.92.9.3633 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2