Ethanol potentiates the GABAA-activated Cl- current in mouse hippocampal and cortical neurons.

European journal of pharmacology ·Vol. 187 ·No. 1 ·1990-10-02 ·Pages 127-30

Aguayo LG

Abstract

The effects of ethanol (1-80 mM) on GABA-activated Cl- current (IGABA) were studied in cultured mammalian hippocampal and cortical neurons. Patch-clamp recordings revealed that ethanol potentiated the Cl- current in a concentration-dependent manner (1-40 mM) in the majority of the cells studied. No higher degree of potentiation was found by increasing the concentration of ethanol to 80 mM. This study demonstrates that ethanol can potentiate IGABA in mammalian central neurons.

MeSH Terms

Animals Cerebral Cortex/cytology,metabolism Chlorides/metabolism Electrophysiology Ethanol/pharmacology Hippocampus/cytology,metabolism Ion Channels/drug effects,metabolism Mice Neurons/drug effects,metabolism gamma-Aminobutyric Acid/pharmacology

Chemicals

Chlorides Ion Channels Ethanol gamma-Aminobutyric Acid

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Aguayo L G

Section of Electrophysiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852.

Article Info

Journal

European journal of pharmacology

Abbr.

Eur J Pharmacol

ISSN

0014-2999

DOI

10.1016/0014-2999(90)90349-b

Published

1990-10-02

Pages

127-30

Language

English

Region

Netherlands

NLM ID

1254354

Subset

External Links

PubMed source DOI: 10.1016/0014-2999(90)90349-b View journal details

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Ethanol potentiates the GABAA-activated Cl- current in mouse hippocampal and cortical neurons.

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