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PMID: 7651832 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions.

Nucleic acids research ·Vol. 23 ·No. 14 ·1995-07-25 ·Pages 2715-23

Eisen JA, Sweder KS, Hanawalt PC

Abstract

The SNF2 family of proteins includes representatives from a variety of species with roles in cellular processes such as transcriptional regulation (e.g. MOT1, SNF2 and BRM), maintenance of chromosome stability during mitosis (e.g. lodestar) and various aspects of processing of DNA damage, including nucleotide excision repair (e.g. RAD16 and ERCC6), recombinational pathways (e.g. RAD54) and post-replication daughter strand gap repair (e.g. RAD5). This family also includes many proteins with no known function. To better characterize this family of proteins we have used molecular phylogenetic techniques to infer evolutionary relationships among the family members. We have divided the SNF2 family into multiple subfamilies, each of which represents what we propose to be a functionally and evolutionarily distinct group. We have then used the subfamily structure to predict the functions of some of the uncharacterized proteins in the SNF2 family. We discuss possible implications of this evolutionary analysis on the general properties and evolution of the SNF2 family.

MeSH Terms
Amino Acid Sequence Animals Biological Evolution Conserved Sequence DNA Helicases DNA-Binding Proteins/classification,genetics Humans Molecular Sequence Data Nuclear Proteins Phylogeny Sequence Alignment Sequence Homology, Amino Acid Software Transcription Factors/classification,genetics
Chemicals
DNA-Binding Proteins Nuclear Proteins SMARCA1 protein, human SMARCA2 protein, human Transcription Factors SMARCA4 protein, human DNA Helicases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Eisen J A
Department of Biological Sciences, Stanford University, CA 94305-5020, USA.
Sweder K S
Hanawalt P C
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/23.14.2715
Published
1995-07-25
Pages
2715-23
Language
English
Region
England
NLM ID
0411011
PMCID
PMC307096
Subset
IM
Grants
NCI NIH HHS · CA44349 · United States
NIAMS NIH HHS · T32AR07422 · United States
External Links
PubMed source DOI: 10.1093/nar/23.14.2715 PMC Full Text View journal details
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