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PMID: 7503691 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

BK virus and a new type of JC virus excreted by HIV-1 positive patients in rural Tanzania.

Archives of virology ·Vol. 140 ·No. 11 ·1995-00-00 ·Pages 1919-34

Agostini HT, Brubaker GR, Shao J, Levin A, Ryschkewitsch CF, Blattner WA, Stoner GL

Abstract

HIV-1 positive patients from Tanzanian villages near Shirati were examined for urinary excretion of the human polyomaviruses JC and BK using the polymerase chain reaction (PCR). BK virus (BKV) was detected in 11 of 23 individuals tested. The BKV DNA sequences were all closely related to prototype Gardner strain and BKV (DUN). In contrast, a new type of JCV, termed Type 3 [or JCV (Shi)], was identified in seven of these same 23 individuals by comparison with Type 1 and Type 2 sequences of the VP1/intergenic/T antigen region of U.S., European and Asian strains. This suggests that JCV and BKV, although closely related, have different evolutionary histories within the African population. The six BKV regulatory regions amplified all showed the archetypal configuration. However, two of the seven JCV regulatory regions showed rearrangements: a small deletion and an inverted repeat. JCV causes a fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML), in about 5% of AIDS patients in Europe and the U.S.A., but only one case has been reported in Africa. Our results suggest that this rarity of PML is not due to the absence of JCV in the African population.

Keywords
Africa Africa South Of The Sahara Biology Demographic Factors Developing Countries Diseases Eastern Africa English Speaking Africa Examinations And Diagnoses Genetics Hiv Infections Laboratory Examinations And Diagnoses Laboratory Procedures Neurologic Effects Physiology Population Population Characteristics Research Report Rural Population Signs And Symptoms Tanzania Viral Diseases
MeSH Terms
Adolescent Adult Amino Acid Sequence BK Virus/genetics,growth & development Base Sequence Capsid/genetics DNA Primers/chemistry DNA, Viral/urine Female HIV Infections/complications,microbiology Humans JC Virus/classification,genetics,growth & development Male Middle Aged Molecular Sequence Data Papillomavirus Infections/complications Regulatory Sequences, Nucleic Acid Tanzania
Chemicals
DNA Primers DNA, Viral
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Agostini H T
Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.
Brubaker G R
Shao J
Levin A
Ryschkewitsch C F
Blattner W A
Stoner G L
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01322682
Published
1995-00-00
Pages
1919-34
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
Grants
NCI NIH HHS · N01-CP-33005 · United States
Databases
GENBANK
U21836, U21837, U21838, U21841, U21842, U21843, U21844
External Links
PubMed source DOI: 10.1007/BF01322682 View journal details
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