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PMID: 1649346 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

BK virus and JC virus shed during pregnancy have predominantly archetypal regulatory regions.

Journal of virology ·Vol. 65 ·No. 8 ·1991-08-00 ·Pages 4515-9

Markowitz RB, Eaton BA, Kubik MF, Latorra D, McGregor JA, Dynan WS

Abstract

Twenty-three BK virus and JC virus DNA samples obtained from urine of pregnant women had almost exclusively archetypal transcriptional control regions. Rearrangements characteristic of laboratory strains are apparently not required for reactivation in humans. Unexpectedly, alignment shows that many elements identified previously in the BK virus enhancer are conserved in the JC virus archetype.

MeSH Terms
BK Virus/genetics Base Sequence DNA, Viral/genetics Enhancer Elements, Genetic Female Gene Rearrangement Humans JC Virus/genetics Molecular Sequence Data Polymerase Chain Reaction Pregnancy Pregnancy Complications, Infectious/microbiology,urine Promoter Regions, Genetic Regulatory Sequences, Nucleic Acid Transcription, Genetic Tumor Virus Infections/microbiology,urine Urine/microbiology
Chemicals
DNA, Viral
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Markowitz R B
Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309-0215.
Eaton B A
Kubik M F
Latorra D
McGregor J A
Dynan W S
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.65.8.4515-4519.1991
Published
1991-08-00
Pages
4515-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC248896
Subset
IM
Grants
NCI NIH HHS · CA 44958 · United States
External Links
PubMed source DOI: 10.1128/JVI.65.8.4515-4519.1991 PMC Full Text View journal details
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