Cytoskeletal and muscle-like elements in cochlear hair cells.
Monospecific antibodies to actin and to tubulin were used as immunofluorescent probes to evaluate the distribution of microtubules and actin filaments in the organ of Corti in mouse and guinea pig. The results indicate that in cochlear receptor cells actin and actin filaments as well as tubulin and microtubules are integral cytoskeletal elements. The presence of actin suggests a possible contractile mechanism within the sensory cilia whereas tubulin is thought to play an important role in the stability of sensory cells. Both proteins are discussed to form structural elements required for the mechano-chemical coupling in hearing.
22 references, click to expand
-
Phalloidin-induced cholestasis: a microfilament-mediated change in junctional complex permeability.Proc Natl Acad Sci U S A. 1980 Apr;77(4):2229-33 PMID: 6929547
-
Pressure-induced depolymerization of spindle microtubules. III. Differential stability in HeLa cells.J Cell Biol. 1976 May;69(2):443-54 PMID: 1262399
-
Muscle-like contractile proteins and tubulin in synaptosomes.Proc Natl Acad Sci U S A. 1974 Nov;71(11):4472-6 PMID: 4530997
-
Microtubule assembly in the absence of added nucleotides.Proc Natl Acad Sci U S A. 1973 Mar;70(3):765-8 PMID: 4514990
-
Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin A.Proc Natl Acad Sci U S A. 1972 Mar;69(3):608-12 PMID: 4551979
-
The organization of actin filaments in the stereocilia of cochlear hair cells.J Cell Biol. 1980 Jul;86(1):244-59 PMID: 6893452
-
Immunofluorescence of mitotic spindles by using monospecific antibody against bovine brain tubulin.Science. 1975 Mar 14;187(4180):948-50 PMID: 1096300
-
Fluorescence techniques for following interactions of microtubule subunits and membranes.Nature. 1975 Mar 13;254(5496):152-4 PMID: 1118005
-
Organization of an actin filament-membrane complex. Filament polarity and membrane attachment in the microvilli of intestinal epithelial cells.J Cell Biol. 1975 Dec;67(3):725-43 PMID: 1202021
-
Tension generation by actomyosin thread from a non-muscle system.Nature. 1980 May 15;285(5761):169-71 PMID: 7374767
-
Studies on the sensory hairs of receptor cells in the inner ear.Acta Otolaryngol. 1977 Jan-Feb;83(1-2):85-91 PMID: 842331
-
Ultrastructural localization of the high molecular weight proteins associated with in vitro-assembled brain microtubules.J Cell Biol. 1975 Apr;65(1):237-41 PMID: 1127013
-
[Hair cell damage pattern following parenteral gentamicin administration in guinea pigs].Z Laryngol Rhinol Otol. 1972 Dec;51(12):845-66 PMID: 4565782
-
Actin filaments in sensory hairs of inner ear receptor cells.J Cell Biol. 1977 Nov;75(2 Pt 1):339-43 PMID: 318131
-
Brownian motion in the cochlear partition.J Acoust Soc Am. 1968 Jul;44(1):176-86 PMID: 5659832
-
Biochemistry of actomyosin-dependent cell motility (a review).Proc Natl Acad Sci U S A. 1978 Feb;75(2):588-99 PMID: 147464
-
Microtubular proteins in pigeon erythrocyte membranes.Eur J Biochem. 1976 Dec;71(1):177-84 PMID: 827444
-
Protein measurement with the Folin phenol reagent.J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
-
Selective enzyme purification by affinity chromatography.Proc Natl Acad Sci U S A. 1968 Oct;61(2):636-43 PMID: 4971842
-
Microtubules.Annu Rev Biochem. 1973;42:507-40 PMID: 4581232
-
Stereo immunofluorescence microscopy: I. Three-dimensional arrangement of microfilaments, microtubules and tonofilaments.Cell. 1978 Jul;14(3):477-88 PMID: 357010
-
CYTOARCHITECTURE OF THE ORGAN OF CORTI.Acta Otolaryngol Suppl. 1964;188:SUPPL 188:92-9 PMID: 14143618
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