Home LiteratureArticle Details
PMID: 7009282 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

The milieu interieur and the islets of Langerhans.

Diabetologia ·Vol. 20 ·No. 1 ·1981-00-00 ·Pages 1-11

Unger RH

Abstract

暂无摘要

MeSH Terms
Animals Brain/physiology Diabetes Mellitus/physiopathology Glucagon/physiology Glucose/metabolism Humans Insulin/physiology Islets of Langerhans/physiology Liver/metabolism Models, Biological Stress, Physiological/physiopathology
Chemicals
Insulin Glucagon Glucose
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Unger R H
References (72)
72 references, click to expand
  1. Hormonal control of ketogenesis. Biochemical considerations.
    Arch Intern Med. 1977 Apr;137(4):495-501 PMID: 403870
  2. [Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction in man induced by secretin and cholecystokinin-pancreozymin administration (author's transl)].
    Dtsch Med Wochenschr. 1975 May 16;100(20):1135-8 PMID: 1126301
  3. Glucagon: role in the hyperglycemia of diabetes mellitus.
    Science. 1975 Feb 14;187(4176):544-7 PMID: 1089999
  4. Glucagon and plasma catecholamines during beta-receptor blockade in exercising man.
    J Appl Physiol. 1976 Jun;40(6):855-63 PMID: 931921
  5. Inhibition of insulin secretion by somatostatin.
    Lancet. 1973 Dec 8;2(7841):1299-301 PMID: 4127645
  6. Essential roles of insulin and glucagon in regulating glucose fluxes during exercise in dogs.
    Diabetes. 1979 Jan;28 Suppl 1:45-52 PMID: 761713
  7. Identification of insulin in rat brain.
    Proc Natl Acad Sci U S A. 1978 Nov;75(11):5737-41 PMID: 364489
  8. The effect of experimental insulin deficiency on glucagon secretion.
    J Clin Invest. 1971 Sep;50(9):1992-9 PMID: 4935445
  9. The incretin concept today.
    Diabetologia. 1979 Feb;16(2):75-85 PMID: 32119
  10. Diabetic cataract formation: potential role of glycosylation of lens crystallins.
    Proc Natl Acad Sci U S A. 1978 Jun;75(6):2918-22 PMID: 275862
  11. Effect of acetyl choline on the secretion of glucagon and insulin from the isolated, perfused canine pancreas.
    Diabetes. 1973 May;22(5):381-7 PMID: 4700051
  12. Abnormalities of glucagon metabolism in untreated diabetes mellitus.
    Lancet. 1972 Dec 30;2(7792):1394-5 PMID: 4118687
  13. Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon.
    N Engl J Med. 1975 May 8;292(19):985-9 PMID: 804137
  14. Studies of the physiology and pathophysiology of the pancreatic D cell.
    Metabolism. 1978 Sep;27(9 Suppl 1):1227-32 PMID: 682985
  15. Somatostatin: hypothalamic inhibitor of the endocrine pancreas.
    Science. 1974 Apr 26;184(4135):482-4 PMID: 4594711
  16. Effect of glucose on plasma glucagon and free fatty acids during prolonged exercise.
    Eur J Appl Physiol Occup Physiol. 1978 Jul 17;39(1):53-61 PMID: 679944
  17. Antagonism between the effects of insulin and glucagon on the isolated liver.
    Diabetes. 1969 Nov;18(11):724-32 PMID: 5348515
  18. Search for a biochemical basis of diabetic microangiopathy.
    Diabetologia. 1976 Mar;12(1):1-14 PMID: 767187
  19. A morphological basis for intercellular communication between alpha- and beta-cells in the endocrine pancreas.
    J Clin Invest. 1975 Oct;56(4):1066-70 PMID: 1099118
  20. The Banting Memorial Lecture 1975. Diabetes and the alpha cell.
    Diabetes. 1976 Feb;25(2):136-51 PMID: 814024
  21. Continuous subcutaneous insulin infusion in the treatment of diabetes mellitus.
    Diabetes Care. 1980 Mar-Apr;3(2):290-300 PMID: 6993143
  22. Stimulation of insulin secretion by gastric inhibitory polypeptide in man.
    J Clin Endocrinol Metab. 1973 Nov;37(5):826-8 PMID: 4749457
  23. Pancreatic alpha-cell function in trauma.
    JAMA. 1974 Feb 18;227(7):757-61 PMID: 4590022
  24. Effect of insulin-glucose infusions on plasma glucagon levels in fasting diabetics and nondiabetics.
    J Clin Invest. 1975 Nov;56(5):1132-8 PMID: 1184740
  25. Hypothesis: physiologic role of pancreatic somatostatin and the contribution of D-cell disorders to diabetes mellitus.
    Life Sci. 1977 Jun 15;20(12):2081-5 PMID: 329036
  26. Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone.
    Lancet. 1974 Nov 9;2(7889):1106-9 PMID: 4139406
  27. Metabolic coupling, ionic coupling and cell contacts.
    Nature. 1972 Feb 4;235(5336):262-5 PMID: 4551177
  28. Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion.
    N Engl J Med. 1970 Jul 16;283(3):109-15 PMID: 4912452
  29. Neuronal localization of pancreatic polypeptide (PP) and vasoactive intestinal peptide (VIP) immunoreactivity in the earthworm (Lumbricus terrestris).
    Brain Res Bull. 1977 Jan-Feb;2(1):61-5 PMID: 861774
  30. The role of calcium in alpha-adrenergic inactivation of glycogen synthase in rat hepatocytes and its inhibition by insulin.
    Diabetes. 1980 Aug;29(8):617-22 PMID: 6777224
  31. Decreased pancreatic somatostatin (SRIF) concentration in spontaneously diabetic mice.
    Endocrinology. 1976 Nov;99(5):1415-8 PMID: 991829
  32. Effect of hypothalamic stimulation on plasma glucose, insulin, and glucagon levels.
    Am J Physiol. 1971 Dec;221(6):1596-603 PMID: 4941906
  33. PLasma glucagon levels during rapid exsanguination with and without adrenergic blockade.
    Diabetes. 1975 Apr;24(4):313-6 PMID: 236964
  34. Effect of somatostatin on meal-stimulated pancreatic exocrine secretions in dogs.
    Diabetes. 1977 Jan;26(1):7-10 PMID: 830567
  35. Effect of glucagon on glucose production during insulin deficiency in the dog.
    J Clin Invest. 1978 Sep;62(3):664-77 PMID: 690190
  36. Effect of insulin on the exaggerated glucagon response to arginine stimulation in diabetes mellitus.
    Diabetes. 1976 Mar;25(3):227-9 PMID: 1254112
  37. Hyperglucagonaemia after burns.
    Lancet. 1974 Jan 19;1(7847):73-5 PMID: 4129210
  38. Proceedings: Effect of somatostatin on motilin levels and gastric emptying.
    Gut. 1975 Oct;16(10):834 PMID: 1205307
  39. Pancreatic immunoreactive somatostatin release.
    Proc Natl Acad Sci U S A. 1977 May;74(5):2140-3 PMID: 325567
  40. Somatostatin suppresses secretin and pancreatic exocrine secretion.
    Science. 1975 Oct 10;190(4210):163-5 PMID: 1166308
  41. Abnormal alpha cell function in human diabetes: the response to oral protein.
    Am J Med. 1978 Jun;64(6):988-97 PMID: 350047
  42. The essential role of glucagon in the pathogenesis of diabetes mellitus.
    Lancet. 1975 Jan 4;1(7897):14-6 PMID: 46337
  43. The effect of adrenergic blockade on exercise-induced hyperglucagonemia.
    Endocrinology. 1974 May;94(5):1254-8 PMID: 4823508
  44. [Evolution of hormonal parameters (glucagon, cortisol, growth hormone) and energetic parameters (glucose, fatty acids, free glycerol) in 10 severe cases of diabetic acido-ketosis under treatment].
    Pathol Biol (Paris). 1969 Dec;17(23):1095-105 PMID: 4985195
  45. The effect of epinephrine on immunoreactive insulin levels in man.
    J Clin Invest. 1966 Feb;45(2):228-36 PMID: 5901508
  46. Embryology of the diffuse neuroendocrine system and its relationship to the common peptides.
    Fed Proc. 1979 Aug;38(9):2288-94 PMID: 37125
  47. The effect of somatostatin on release and insulinotropic action of gastric inhibitory polypeptide.
    Can J Physiol Pharmacol. 1975 Dec;53(6):1200-5 PMID: 1222389
  48. Possible roles of the pancreatic D-cell in the normal and diabetic states.
    Diabetes. 1977 Mar;26(3):241-4 PMID: 320077
  49. PROMOTION OF INSULIN SECRETION BY GLUCAGON.
    Lancet. 1965 Aug 28;2(7409):415-6 PMID: 14346763
  50. The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus.
    Metabolism. 1975 Nov;24(11):1287-97 PMID: 1186499
  51. Glucagon-like polypeptides in canine brain.
    Diabetes. 1979 Jul;28(7):700-2 PMID: 446926
  52. Entero-insular axis.
    Arch Intern Med. 1969 Mar;123(3):261-6 PMID: 4885674
  53. The effects of gastrin, gastric inhibitory polypeptide, secretin, and the octapeptide of cholecystokinin upon immunoreactive somatostatin release by the perfused canine pancreas.
    J Clin Invest. 1977 Nov;60(5):1216-9 PMID: 908761
  54. Direct stimulation by growth hormone of glucagon and insulin release from isolated rat pancreas.
    Endocrinology. 1976 Sep;99(3):669-77 PMID: 954663
  55. Posttranslational covalent modification of proteins.
    Science. 1977 Dec 2;198(4320):890-6 PMID: 337487
  56. Changes in glucagon levels after four to five weeks of glucoregulation by portable insulin infusion pumps.
    Diabetes. 1979 Nov;28(11):1033-5 PMID: 488544
  57. Effects of exogenous hyperglucagonemia in insulin-treated diabetics.
    Diabetes. 1977 Nov;26(11):1034-9 PMID: 410690
  58. Direct inhibition of gastric acid and pepsin secretion by growth-hormone release-inhibiting hormone in cats.
    Lancet. 1975 Apr 19;1(7912):888-90 PMID: 47536
  59. Role of glucagon in the pathogenesis of diabetes: the status of the controversy.
    Metabolism. 1978 Nov;27(11):1691-709 PMID: 360007
  60. Role of nonenzymatic glycosylation in the development of the sequelae of diabetes mellitus.
    Metabolism. 1979 Apr;28(4 Suppl 1):431-7 PMID: 122296
  61. Inhibition of cholecystokinin-pancreozymin release by somatostatin.
    Lancet. 1977 Jul 23;2(8030):166-8 PMID: 69783
  62. Hyperglucagonism induced by glucocorticoid treatment in man.
    N Engl J Med. 1973 Jan 18;288(3):128-31 PMID: 4682036
  63. Glucagon deficiency causing severe neonatal hypoglycemia in a patient with normal insulin secretion.
    Pediatr Res. 1977 Sep;11(9 Pt 1):943-9 PMID: 904979
  64. Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes.
    N Engl J Med. 1978 Aug 31;299(9):433-6 PMID: 683275
  65. Functional subdivision of islets of Langerhans and possible role of D cells.
    Lancet. 1975 Dec 20;2(7947):1243-4 PMID: 53729
  66. Effects of starvation on plasma pancreatic glucagon in normal man.
    Diabetes. 1969 Nov;18(11):717-23 PMID: 5348514
  67. Morphine and beta-endorphin influence the secretion of the endocrine pancreas.
    Nature. 1978 Nov 9;276(5684):190-1 PMID: 216921
  68. Studies of pancreatic alpha cell function in normal and diabetic subjects.
    J Clin Invest. 1970 Apr;49(4):837-48 PMID: 4986215
  69. The effect of somatostatin on the response of GLI to the intraduodenal administration of glucose, protein, and fat.
    Diabetologia. 1975 Oct;11(5):427-30 PMID: 1181667
  70. Evidence for a role of splanchnic somatostatin in the homeostasis of ingested nutrients.
    Endocrinology. 1979 Jun;104(6):1705-8 PMID: 446390
  71. Splanchnic somatostatin: a hormonal regulator of nutrient homeostasis.
    Science. 1980 Feb 1;207(4430):530-2 PMID: 7352262
  72. Pancreatic glucagon secretion in normal and diabetic subjects.
    Am J Med Sci. 1969 Jun;257(6):415-9 PMID: 4893149
Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00253809
Published
1981-00-00
Pages
1-11
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
Grants
NIADDK NIH HHS · AM-02700 · United States
NIADDK NIH HHS · N01-AM-62219 · United States
External Links
PubMed source DOI: 10.1007/BF00253809 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2