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PMID: 908761 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The effects of gastrin, gastric inhibitory polypeptide, secretin, and the octapeptide of cholecystokinin upon immunoreactive somatostatin release by the perfused canine pancreas.

The Journal of clinical investigation ·Vol. 60 ·No. 5 ·1977-11-00 ·Pages 1216-9

Ipp E, Dobbs RE, Harris V, Arimura A, Vale W, Unger RH

Abstract

The effects of gastrin, gastric inhibitory polypeptide, secretin, and the octapeptide of pancreozymin-cholecystokinin on immunoreactive somatostatin release were studied in the isolated perfused dog pancreas. Gastrin at a concentration of 65 ng/ml and the octapeptide of pancreozymin-cholecystokinin at a concentration of 25 ng/ml produced a prompt, but transient statistically significant, twofold rise in mean somatostatin concentration. Secretion at a concentration of 0.3 U/ml and gastric inhibitory polypeptide concentration of 58 ng/ml produced a prompt two- to threefold rise in mean somatostatin release, which persisted throughout the perfusion period. With all four polypeptides the pattern of the somatostatin response resembled that of insulin. It appears that pancreatic somatostatin release is stimulated by gastrointestinal hormones that influence the secretion of insulin and glucagon.

MeSH Terms

Animals Cholecystokinin/analogs & derivatives,pharmacology Dogs Gastric Inhibitory Polypeptide/pharmacology Gastrins/pharmacology Gastrointestinal Hormones/pharmacology In Vitro Techniques Pancreas/drug effects,metabolism Perfusion Secretin/pharmacology Somatostatin/metabolism

Chemicals

Gastrins Gastrointestinal Hormones Secretin Somatostatin Gastric Inhibitory Polypeptide Cholecystokinin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Ipp E

Dobbs R E

Harris V

Arimura A

Vale W

Unger R H

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25 references, click to expand

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Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI108875

Published

1977-11-00

Pages

1216-9

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC372476

Subset

External Links

PubMed source DOI: 10.1172/JCI108875 PMC Full Text View journal details

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The effects of gastrin, gastric inhibitory polypeptide, secretin, and the octapeptide of cholecystokinin upon immunoreactive somatostatin release by the perfused canine pancreas.

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