Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 4 ·1975-04-00 ·Pages 1340-3

Dubois MP

Abstract

A discrete population of cells of the endocrine pancreas contains immunoreactive somatostatin as shown by immunofluorescence. These cells are different from those containing glucagon or insulin. This unexpected observation may be of physiopathological significance in the regulatory mechanisms involved in the secretion of glucagon and insulin.

MeSH Terms

Animals Antibodies Cats Chickens Cross Reactions Fluorescent Antibody Technique Glucagon Humans Insulin Antibodies Pancreas/analysis,immunology Rabbits/immunology Rats Sheep Somatostatin/immunology Species Specificity Swine

Chemicals

Antibodies Insulin Antibodies Somatostatin Glucagon

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Dubois M P

References (8)

8 references, click to expand

The neural ectodermal origin of the peptide-secreting endocrine glands. A unifying concept for the etiology of multiple endocrine adenomatosis and the inappropriate secretion of peptide hormones by nonendocrine tumors.
Am J Med. 1970 Aug;49(2):232-41 PMID: 4393822
Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.
Science. 1973 Jan 5;179(4068):77-9 PMID: 4682131
[Preliminary observations on the mechanism of action of somatostatin, a hypothalamic factor inhibiting the secretion of growth hormone].
C R Acad Sci Hebd Seances Acad Sci D. 1972 Dec 18;275(25):2913-6 PMID: 4347575
Primary structure of somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone.
Proc Natl Acad Sci U S A. 1973 Mar;70(3):684-8 PMID: 4514982
Somatostatin. Total solid phase synthesis.
J Am Chem Soc. 1974 May 1;96(9):2986-92 PMID: 4598650
Electron microscopic immunohistochemical localization of growth hormone-release inhibiting hormone (somatostatin) in the rat median eminence.
Am J Anat. 1974 Jul;140(3):445-50 PMID: 4602207
Immunohistochemical localization of somatostatin (growth hormone release-inhibiting factor) in the guinea pig brain.
Brain Res. 1974 Nov 8;80(1):165-9 PMID: 4608681
Electron microscopic description of a third cell type in the islets of the rat pancreas.
Am J Anat. 1963 Jan;112:53-64 PMID: 14018506

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.72.4.1340

Published

1975-04-00

Pages

1340-3

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC432529

Subset

External Links

PubMed source DOI: 10.1073/pnas.72.4.1340 PMC Full Text View journal details

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Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas.

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