Home LiteratureArticle Details
PMID: 1181667 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The effect of somatostatin on the response of GLI to the intraduodenal administration of glucose, protein, and fat.

Diabetologia ·Vol. 11 ·No. 5 ·1975-10-00 ·Pages 427-30

Sakurai H, Dobbs RE, Unger RH

Abstract

The effects of somatostatin on GLI release during the absorption of intraduodenally administered glucose, casein hydrolysate and longchain triglycerides were studied in conscious dogs. Whereas, after an intraduodenal glucose load, GLI rose promptly in saline-infused control experiments to a peak of 5 ng/ml (SEM +/- 4) in 60 minutes, significantly lower values were observed during somatostatin infusion (P less than 0.025 -- 0.05). A similar reduction in the magnitude of the GLI response to intraduodenally administered casein hydrolysate (P less than 0.05) and fat (p less than 0.05) was observed.

MeSH Terms
Animals Blood Glucose/metabolism Caseins/administration & dosage Depression, Chemical Dogs Duodenum/metabolism Gastrointestinal Hormones/metabolism Glucagon/blood,metabolism Glucose/administration & dosage Insulin/blood Intestinal Absorption Intubation, Gastrointestinal Protein Hydrolysates/administration & dosage Somatostatin/pharmacology Triglycerides/administration & dosage
Chemicals
Blood Glucose Caseins Gastrointestinal Hormones Insulin Protein Hydrolysates Triglycerides Somatostatin Glucagon Glucose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sakurai H
Dobbs R E
Unger R H
References (21)
21 references, click to expand
  1. [Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction in man induced by secretin and cholecystokinin-pancreozymin administration (author's transl)].
    Dtsch Med Wochenschr. 1975 May 16;100(20):1135-8 PMID: 1126301
  2. Inhibition of pancreatic glucagon responses to arginine by somatostatin in normal man and in insulin-dependent diabetics.
    Diabetes. 1974 Nov;23(11):876-80 PMID: 4430415
  3. Inhibition of insulin secretion by somatostatin.
    Lancet. 1973 Dec 8;2(7841):1299-301 PMID: 4127645
  4. Effects of growth-hormone release-inhibiting hormone on circulating glucagon, insulin, and growth hormone in normal, diabetic, acromegalic, and hypopituitary patients.
    Lancet. 1974 Apr 20;1(7860):697-701 PMID: 4132421
  5. Coated charcoal immunoassay of insulin.
    J Clin Endocrinol Metab. 1965 Oct;25(10 ):1375-84 PMID: 5320561
  6. Somatostatin: hypothalamic inhibitor of the endocrine pancreas.
    Science. 1974 Apr 26;184(4135):482-4 PMID: 4594711
  7. Immunoassay of endogenous plasma insulin in man.
    J Clin Invest. 1960 Jul;39:1157-75 PMID: 13846364
  8. Acute suppression of insulin and glucose levels by synthetic somatostatin in normal human subjects.
    J Clin Endocrinol Metab. 1974 May;38(5):913-5 PMID: 4823929
  9. Somatostatin-induced changes in insulin and glucagon secretion in normal and diabetic dogs.
    J Clin Invest. 1974 Dec;54(6):1395-402 PMID: 4436439
  10. Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone.
    Lancet. 1974 Nov 9;2(7889):1106-9 PMID: 4139406
  11. Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion.
    N Engl J Med. 1970 Jul 16;283(3):109-15 PMID: 4912452
  12. Determination of pancreatic and gut glucagon-like immunoreactivity (GLI) in normal and diabetic subjects.
    Diabetologia. 1972 Dec;8(6):408-11 PMID: 4675088
  13. Characterization of glucagon-like immunoreactivity (GLI).
    Diabetes. 1970 Sep;19(9):614-23 PMID: 4990293
  14. Characterization of the responses of circulating glucagon-like immunoreactivity to intraduodenal and intravenous administration of glucose.
    J Clin Invest. 1968 Jan;47(1):48-65 PMID: 5638120
  15. A modified ninhydrin colorimetric analysis for amino acids.
    Arch Biochem Biophys. 1957 Mar;67(1):10-5 PMID: 13412116
  16. Identification of glucagon in the gastrointestinal tract.
    J Clin Invest. 1975 Jul;56(1):135-45 PMID: 237936
  17. Inhibition of growth hormone release in humans by somatostatin.
    J Clin Endocrinol Metab. 1973 Oct;37(4):632-4 PMID: 4742541
  18. Inhibition by somatostatin on the release of TSH induced in man by thyrotropin-releasing factor.
    J Clin Endocrinol Metab. 1974 May;38(5):742-5 PMID: 4207367
  19. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.
    Science. 1973 Jan 5;179(4068):77-9 PMID: 4682131
  20. The effect of calcium and other salts upon the release of glucagon-like immunoreactivity from the gut.
    J Clin Invest. 1972 Apr;51(4):831-6 PMID: 5014613
  21. The effects of triglyceride absorption upon glucagon, insulin, and gut glucagon-like immunoreactivity.
    J Clin Invest. 1973 Oct;52(10):2532-41 PMID: 4738064
Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00429911
Published
1975-10-00
Pages
427-30
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00429911 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2