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PMID: 6998956 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Possible regulation of the Salmonella typhimurium histidine operon by adenosine triphosphate phosphoribosyltransferase: large metabolic effects.

Journal of bacteriology ·Vol. 144 ·No. 1 ·1980-10-00 ·Pages 337-45

Goitein RK, Parsons SM

Abstract

An effort to find growth conditions leading to conditional regulation of the histidine operon of Salmonella typhimurium by the allosteric first enzyme of the pathway, adenosine triphosphate phosphoribosyltransferase (EC 2.4.2.17), is reported. A strain deleting the enzyme, TR3343, behaved simply and predictably under all growth conditions, whereas histidine auxotrophs containing active enzyme behaved in complicated ways dependent upon the location of the histidine pathway lesion. hisE strains derepressed the operon only one-half as much as TR3343 when grown on limiting histidine and a poor carbon source, but they also grew more slowly, probably as a result of high N1-(5-phospho-beta-D-ribosyl)-adenosine triphosphate levels in the cell. hisC strains exhibited oscillatory growth behavior and oscillatory histidine operon expression when grown on intermediate concentrations of the histidine precursor histidinol. This behavior probably was caused by synergistic in-phase variations in the histidine, purine nucleotide, and ppGpp pools of the cell. All of the growth and histidine operon expression effects associated with the presence of adenosine triphosphate phosphoribosyltransferase could be assigned to metabolic perturbation of the cell caused by unregulated enzymatic activity.

MeSH Terms
ATP Phosphoribosyltransferase/physiology Gene Expression Regulation Histidine/biosynthesis Histidinol/metabolism Mutation Operon Pentosyltransferases/physiology Salmonella typhimurium/enzymology,genetics,growth & development
Chemicals
Histidine Histidinol Pentosyltransferases ATP Phosphoribosyltransferase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Goitein R K
Parsons S M
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34 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.144.1.337-345.1980
Published
1980-10-00
Pages
337-45
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC294652
Subset
IM
Grants
NIGMS NIH HHS · GM23031 · United States
External Links
PubMed source DOI: 10.1128/jb.144.1.337-345.1980 PMC Full Text View journal details
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