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PMID: 4895539 Published · ppublish English Journal Article

Studies on repression of the histidine operon. II. The role of the first enzyme in control of the histidine system.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 63 ·No. 2 ·1969-06-00 ·Pages 481-8

Kovach JS, Phang JM, Ference M, Goldberger RF

Abstract

Recent studies on repression of the enzymes for histidine bio-synthesis in Salmonella typhimurium demonstrated that the kinetic pattern in which the enzymes become repressed is influenced by the state of the feedback-sensitive site of the first enzyme of the pathway (Kovach et al., J. Bacteriol., 97, 1283 (1969)). In the present study we demonstrate that under certain conditions alteration of the feedback-sensitive site of the first enzyme prevents repression of the histidine operon. We conclude that the first enzyme plays a previously unrecognized role in regulation of the histidine system.

MeSH Terms
Binding Sites Enzyme Repression Feedback Genetic Code Histidine/biosynthesis Operon Salmonella typhimurium/enzymology Triazoles/pharmacology
Chemicals
Triazoles Histidine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kovach J S
Phang J M
Ference M
Goldberger R F
References (22)
22 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.63.2.481
Published
1969-06-00
Pages
481-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC223589
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.63.2.481 PMC Full Text View journal details
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