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PMID: 6993858 Published · ppublish English Journal Article

An Escherichia coli mutant refractory to nitrosoguanidine mutagenesis.

Molecular & general genetics : MGG ·Vol. 178 ·No. 3 ·1980-00-00 ·Pages 625-31

Ruiz-Vázquez R, Cerdá-Olmedo E

Abstract

A newly-isolated Escherichia coli mutant suffers only about 10% as many mutations as normal strains on exposure to nitrosoguanidine. The responsible mutation, inm-1, maps at approximately minute 79 in the current E. coli genetic map. The mutant is normal for overall growth, nitrosoguanidine lethality, spontaneous mutagenesis, ultraviolet light lethality and mutagenesis, ethyl methanesulfonate lethality and mutagenesis, and the adaptive repair induced by alkylating agents. The existence of this mutation proves that nitrosoguanidine mutagenesis is not merely the result of reactions between the chemical and DNA, but requires specific cellular function(s), and underscores the peculiarity of nitrosoguanidine as a mutagen.

MeSH Terms
Chromosome Mapping Chromosomes, Bacterial Drug Resistance, Microbial Escherichia coli/genetics Mutagens/pharmacology Mutation Nitrosoguanidines/pharmacology Phenotype
Chemicals
Mutagens Nitrosoguanidines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ruiz-Vázquez R
Cerdá-Olmedo E
References (42)
42 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00337870
Published
1980-00-00
Pages
625-31
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00337870
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