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PMID: 934048 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The effect of nitrosoguanidine upon DNA synthesis in vitro.

Molecular & general genetics : MGG ·Vol. 145 ·No. 2 ·1976-05-07 ·Pages 113-7

Jiménez-Sánchez A

Abstract

Both the polymerase and the exonuclease activities of DNA polymerase III are inactivated by treatment with nitrosoguanidine. The treatment of the DNA template with the mutagen does not affect the template in supporting DNA synthesis. No effect of nitrosoguanidine upon fidelity of replication in vitro was detected.

MeSH Terms
Carcinogens DNA Nucleotidyltransferases/metabolism DNA Replication/drug effects Exonucleases/metabolism In Vitro Techniques Mutagens Nitrosoguanidines/pharmacology Templates, Genetic
Chemicals
Carcinogens Mutagens Nitrosoguanidines DNA Nucleotidyltransferases Exonucleases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Jiménez-Sánchez A
References (23)
23 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00269582
Published
1976-05-07
Pages
113-7
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00269582
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