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PMID: 6947275 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 11 ·1981-11-00 ·Pages 7111-4

Steinman L, Rosenbaum JT, Sriram S, McDevitt HO

Abstract

Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord antigen. No protection was evident in animals that received antisera specific for I-Js gene products. Administration of antibody to I-As beginning 5 days after immunization with spinal cord antigen delayed, but did not prevent, the onset of experimental allergic encephalitis.

MeSH Terms
Animals Antibodies, Monoclonal Disease Models, Animal Encephalitis/immunology,prevention & control Immunity, Maternally-Acquired Mice Mice, Inbred Strains Spinal Cord Diseases/immunology,prevention & control
Chemicals
Antibodies, Monoclonal
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Steinman L
Rosenbaum J T
Sriram S
McDevitt H O
References (24)
24 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.11.7111
Published
1981-11-00
Pages
7111-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC349205
Subset
IM
Grants
NINDS NIH HHS · 1K07NS00571-01 · United States
NCRR NIH HHS · 5507 RR 5353-19 · United States
NIAID NIH HHS · AI 07757 · United States
External Links
PubMed source DOI: 10.1073/pnas.78.11.7111 PMC Full Text View journal details
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