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PMID: 106399 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Regulation of immune response to tumor antigen: interference with syngeneic tumor immunity by anti-IA alloantisera.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 2 ·1979-02-00 ·Pages 920-4

Perry LL, Dorf ME, Benacerraf B, Greene MI

Abstract

We present evidence for a role of I-A subregion-encoded determinants in syngeneic tumor immunity. In animals rendered immune to the S1509a fibrosarcoma, daily treatment with microliter quantities of antisera directed against Kk and I-Ak determinants expressed on lymphoid cells of host origin decreased the capacity for immune tumor rejection. Absorption studies revealed that anti-I-Ak antibody activity alone was sufficient for the manifestation of this effect. Furthermore, experiments utilizing F1 hybrids showed that an antiserum that was genetically unable to interact with H-2 determinants expressed on the tumor was equally effective in inhibiting tumor immunity. Suggestive evidence that the activity of this antiserum is related to interference with the generation of effector T cell function was provided by the observation that hyperimmune animals pretreated with an anti-Kk,I-Ak antiserum were no longer capable of adoptively transferring tumor immunity to naive recipients. Thus, it is possible to regulate the secondary immune response to tumor antigens by using antisera with specificity for I-A determinants expressed on cells or possibly on factors of the host lymphoid system.

MeSH Terms
Animals Antigen-Antibody Reactions Antigens, Neoplasm Genes, MHC Class II Graft Rejection Immunization, Passive Immunologic Memory Immunosuppression Therapy Isoantibodies Major Histocompatibility Complex Methylcholanthrene Mice Mice, Inbred Strains Neoplasm Transplantation Neoplasms, Experimental/immunology
Chemicals
Antigens, Neoplasm Isoantibodies Methylcholanthrene
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Perry L L
Dorf M E
Benacerraf B
Greene M I
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25 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.2.920
Published
1979-02-00
Pages
920-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC383093
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.2.920 PMC Full Text View journal details
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